Alex Fornito
connectome | brain imaging | complex networks | graph theory | MRI | cognitive neuroscience
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Predicting cognitive and mental health traits and their polygenic architecture using large-scale brain connectomics
Cognitive abilities and mental disorders are complex traits sharing a largely unknown neuronal basis and aetiology. Their genetic architectures are highly polygenic and overlapping, which is supported by heterogeneous phenotypic expression and...
Graph Theoretical Approaches to Functional Brain Mapping
In this Scipertise tutorial, Dr. Mac Shine will outline graph theoretical approaches to functional brain mapping.
Cluster failure revisited: Impact of first level design and physiological noise on cluster false positive rates. - PubMed - NCBI
Hum Brain Mapp. 2019 May;40(7):2017-2032. doi: 10.1002/hbm.24350. Epub 2018 Oct 15.
Cluster failure: Why fMRI inferences for spatial extent have inflated false-positive rates. - PubMed - NCBI
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7900-5. doi: 10.1073/pnas.1602413113. Epub 2016 Jun 28. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Classification of temporal ICA components for separating global noise from fMRI data: Reply to power
We respond to a critique of our temporal Independent Components Analysis method for separating global noise from global signal in fMRI data that focus…
Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes
Despite significant research, the biological mechanisms underlying schizophrenia are still unclear. We shed light on structural brain differences in psychosis using an approach called morphometric similarity mapping, which quantifies the structural...
Advantages of Multi-shell Diffusion Models for Studies of Brain Development in Youth
Diffusion-weighted imaging (DWI) has advanced our understanding of how brain microstructure evolves during neurodevelopment. Most existing studies of brain development use a simple scalar measure - fractional anisotropy (FA) - to characterize brain...
Metrics for Graph Comparison: A Practitioner's Guide
Comparison of graph structure is a ubiquitous task in data analysis and machine learning, with diverse applications in fields such as neuroscience, cyber security, social network analysis, and bioinformatics, among others. Discovery and comparison...
Gamble, drink, consume, repeat: Why we need BrainPark
Australians have some of the highest rates of addiction-related problems in the world. Treatment services are often over-stretched, inaccessible, or ineffective. At the same time, revolutionary neuroscientific discoveries have revealed how lifestyle...
Generating random networks that consist of a single connected component with a given degree distribution
We present a method for the construction of ensembles of random networks that consist of a single connected component with a given degree distribution. This approach extends the construction toolbox of random networks beyond the configuration model...
Genetics of brain age suggest an overlap with common brain disorders
Numerous genetic and environmental factors contribute to psychiatric disorders and other brain disorders. Common risk factors likely converge on biological pathways regulating the optimization of brain structure and function across the lifespan....
Lunch with Mentors
The OHBM Student and Postdoc SIG Lunch with Mentors event provides trainees with the opportunity to informally chat about the secrets for success (in academia and industry) with assigned mentors. We will provide a catered lunch during this session....
Functional connectomics of affective and psychotic pathology
Converging evidence indicates that groups of patients with nominally distinct psychiatric diagnoses are not separated by sharp or discontinuous neurobiological boundaries. In healthy populations, individual differences in behavior are reflected in...
Firsts in network science
Our field is interdisciplinary and many smart people have been thinking about similar things. No wonder things get reinvented and rediscovered many times. I don’t think science is a competition to …
ADHD symptoms map onto noise-driven structure-function decoupling between hub and peripheral brain regions
Adults with childhood-onset attention-deficit hyperactivity disorder (ADHD) show altered whole-brain connectivity. However, the relationship between structural and functional brain abnormalities, the implications for the development of life-long...
This physicist is trying to make sense of the brain’s tangled networks
Brought up to think she couldn’t go to college, Danielle Bassett now believes she can capture the brain’s dynamics in a set of equations to optimize learning or treat diseases
Distinctions among real and apparent respiratory motions in human fMRI data
Head motion estimates in functional magnetic resonance imaging (fMRI) scans appear qualitatively different with sub-second image sampling rates compared to the multi-second sampling rates common in the past. Whereas formerly the head appeared still...
Multiscale Structure–Function Gradients in the Neonatal Connectome
Abstract. The adult functional connectome is well characterized by a macroscale spatial gradient of connectivity traversing from unimodal toward higher-order t