Anirban Maitra
Scientific Director of the Ahmed Center for Pancreatic Cancer Research at MD Anderson Cancer Ctr. Also a GI Pathologist. Tweets & opinions expressed are my own.
Last synced from Twitter 13m ago
Katherine Johnson
NASA.gov brings you the latest images, videos and news from America's space agency. Get the latest updates on NASA missions, watch NASA TV live, and learn about our quest to reveal the unknown and benefit all humankind.
A single-dose HPV vaccine would greatly aid cancer prevention
One dose of the HPV vaccine may be as good as two doses at warding off this viral infection. That would be good for preventing cancer.
Anirban Maitra
From the desk of @RonDePinho in @statnews:
The importance of even a single dose of #HPVvaccine in cancer prevention.
14h
Cancer patients and the flu: What you should know
What do cancer patients need to know about the flu virus, and what should you do if you catch it? Find out from Roy Chemaly, M.D.
NOT-OD-20-011: NIH Extension Policy for Eligibility Window for Pathway to Independence Awards (K99/R00)
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: NIH Extension Policy for Eligibility Window for Pathway to Independence Awards (K99/R00) NOT-OD-20-011. NIH
1
Anirban Maitra
@IBCradiation @PrajnanDasMD @ACKoongMDPhD @McNeill_Dr @KellyKhunt @mkmartel1 Some programmatic changes at the NIH level that have happened in past year:
A: for K99 awardees
grants.nih.gov/grants/guide/n…
B: For ESIs
grants.nih.gov/grants/guide/n…
C: At the institutional level, @VirusesImmunity made the strong case for on site childcare which could be transformational
29h
NOT-OD-19-125: Notice of System Change and Procedure for Requesting an Extension to Early Stage Investigator (ESI) Status
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of System Change and Procedure for Requesting an Extension to Early Stage Investigator (ESI) Status NOT-OD-19-125. NIH
1
Anirban Maitra
@IBCradiation @PrajnanDasMD @ACKoongMDPhD @McNeill_Dr @KellyKhunt @mkmartel1 Some programmatic changes at the NIH level that have happened in past year:
A: for K99 awardees
grants.nih.gov/grants/guide/n…
B: For ESIs
grants.nih.gov/grants/guide/n…
C: At the institutional level, @VirusesImmunity made the strong case for on site childcare which could be transformational
29h
Cancer–neuronal crosstalk and the startups working to silence it
Investors back ‘cancer neuroscience’ outfits as the field breaks out from academia.
Anirban Maitra
ICYMI a recent commentary on the burgeoning field of “cancer neuroscience” by @ElieDolgin featuring @sciencescanner (I like his phrasing of this field as “disconnection biology”)
35h
Cdc42 mediates cancer cell chemotaxis in perineural invasion
Perineural invasion (PNI) is an ominous form of cancer progression along nerves associated with poor clinical outcome. Glial derived neurotrophic factor (GDNF) interacts with cancer cell RET receptors to enable PNI, but downstream events remain...
Anirban Maitra
Perineural (& intraneural) invasion in #PancreaticCancer- the underlying basis for severe, sometimes intractable pain & the “third rail” of metastatic egress.
This @MCR_AACR paper by Richard Wong @sloan_kettering (& late Alan Hall) implicates cdc42 in PNI
35h
Early-onset colorectal cancer: initial clues and current views
The incidence of early-onset colorectal cancer (in patients <50 years old) is increasing at an alarming rate. This Review highlights potential risk factors and putative mechanisms that drive this disease, and suggests likely areas for fruitful...
Anirban Maitra
Recent insights into early onset #colorectalcancer
By @P_J_Buckhaults & colleagues @MUSC_COM @NatRevGastroHep
nature.com/articles/s4157…
Cc: @Rndubois @AnjeeDavis @FightCRC pic.twitter.com/6c18T8nkxD
3d
iNOS regulates the therapeutic response of pancreatic cancer cells to radiation therapy
Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to radiation therapy (RT), chemotherapy, or a combination of these modalities, and surgery remains the only curative intervention for localized disease. Although cancer-associated...
Anirban Maitra
From @LewisLabMSKCC @CpcrMsk : preclinical studies on role of stromal iNOS in attenuating XRT response in #PancreaticCancer
3d
Transforming Growth Factor β Polymorphism C−509T and Radiation-Induced Fibrosis in Breast Cancer
This cohort study of female participants with stage 0 to IIA breast cancer treated with breast-conserving surgery and whole-breast irradiation assesses whether radiation-induced toxicities of normal breast tissue 3 years after radiotherapy are...
Should 'broken' genes be fixed? My daughter changed my thinking
Our second daughter arrived in this world with a shock of white hair. Her albinism took her family on a journey of discovery.
Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses
The new coronavirus (2019-nCoV) outbreak from December 2019 in Wuhan, Hubei, China, has been declared a global public health emergency. Angiotensin I converting enzyme 2 (ACE2), is the host receptor by 2019-nCov to infect human cells. Although ACE2...
Recently Discovered Immune Cell Type May Be Key to Improving Pancreatic Cancer Immunotherapy
Researchers find a potential new route to making immunotherapy work better in pancreatic cancers and possibly others.
Drop in cancer deaths reflect failures of our society. Really - The Boston Globe
When deaths due to poverty, obesity, addiction, and depression rise, cancer death rates automatically fall, because the two categories of death share risk factors.
Alan Rickman: Celebrating a life
Check out this page on the Pancreatic Cancer UK Website
Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis
Regulatory T cells (Treg) are abundant in human and mouse pancreatic cancer. To understand the contribution to the immunosuppressive microenvironment, we depleted Tregs in a mouse model of pancreatic cancer. Contrary to our expectations, Treg...
Geographic and Ethnic Heterogeneity of Germline <i>BRCA1</i> or <i>BRCA2</i> Mutation Prevalence Among Patients With Metastatic Pancreatic Cancer Screened for Entry Into the POLO Trial
PURPOSE Germline BRCA1 and/or BRCA2 mutations (gBRCAms) are risk factors for pancreatic cancer. The extent to which demographic and geographic factors affect the uptake of gBRCAm testing in pancreatic cancer (PC) is unknown. METHODS We conducted a...
Anirban Maitra
Geographic & ethnic heterogeneity of gBRCA1/2 mutations in #PancreaticCancer patients screened for entry into POLO trial.
ascopubs.org/doi/10.1200/JC…
Study underscores why @NCCN & @ASCO endorsed universal germline testing - only minority had prior knowledge of mutation status. pic.twitter.com/66jZ8kS9Yv
5d
ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity
Tumour-infiltrating group 2 innate lymphoid cells prime CD8+ T cells and amplify the anti-tumour effects of PD-1 blockade in pancreatic ductal adenocarcinoma.