Anirban Maitra
Scientific Director of the Ahmed Center for Pancreatic Cancer Research at MD Anderson Cancer Ctr. Also a GI Pathologist. Tweets & opinions expressed are my own.
Last synced from Twitter 17m ago
Optimal Compression Rate–Depth Combination During Cardiopulmonary Resuscitation
Jamanetwork.com 4d 2 tweets
This cohort study of data from the National Institutes of Health clinical trials network database assesses the optimal chest compression rate and depth associated with improved survival after out-of-hospital cardiac arrest and examines whether...
The Histopathology of PRSS1 Hereditary Pancreatitis
PubMed Central (PMC) 33h 1 tweets
Hereditary pancreatitis is an autosomal dominant disorder with 80% penetrance and variable expressivity. The vast majority of cases have been linked to mutations within the cationic trypsinogen gene, also referred to as serine protease 1 (PRSS1)....
Intraductal Papillary Mucinous Neoplasms Arise from Multiple Independent Clones, Each With Distinct Mutations
Gastroenterology 37h 1 tweets
Intraductal papillary mucinous neoplasms (IPMNs) are lesions that can progress to invasive pancreatic cancer and an important system for studies of pancreatic tumorigenesis. We performed comprehensive genomic analyses of entire IPMNs to determine...
Anirban Maitra A Star Wars themed editorial! Intraductal papillary mucinous neoplasms: Attack of the clones. On Laura Wood paper elucidating clonal heterogeneity in early #PancreaticCancer precursors (IPMNs) 37h
Has this scientist finally found the fountain of youth?
MIT Technology Review 11d 7 tweets
Editing the epigenome, which turns our genes on and off, could be the “elixir of life.”
Anirban Maitra The 2019 David Sinclair “Fountain of Youth” Media Hype award goes to: With a rational cameo by 51h
What's Behind A Cluster Of Vaping-Related Hospitalizations?
NPR.org 56h 3 tweets
Dozens of people in the Midwest have been hospitalized with severe lung damage in the past month. It's unclear what exactly is causing the issue but the common link appears to be vaping.
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Anirban Maitra Back to back stories in & on a surge of acute onset pulmonary ailment in teenagers & young adults with a common denominator being vaping. Now the is investigating. Paging 54h
Irinotecan: 25 years of cancer treatment
Sciencedirect.com 56h 1 tweets
Twenty-five years ago, the cytotoxic drug irinotecan (IRT) was first approved in Japan for the treatment of cancer. For more than two decades, the IRT…
Anirban Maitra 25 years of Irinotecan (first approved in 1994) An integral component of FOLFIRINOX, used in first line metastatic #PancreaticCancer, as well as adjuvant Tx in resected disease & in neoadjuvant Rx. 56h
Chief Medical Examiner - OCME
Www1.nyc.gov 134d 2 tweets
Anirban Maitra Fascinating social experiment on implicit bias ongoing on Twitter where so many are just assuming the NYC Medical Examiner is a man. Her name is Dr. Barbara Sampson (PhD Rockefeller U; MD Cornell) & she is the first woman to ever lead the NYC OCME. 57h
Comprehensive Genomic Landscapes in Early and Later Onset Colorectal Cancer
Clinical Cancer Research 3d 1 tweets
Purpose: The incidence rates of colorectal cancers are increasing in young adults. The objective of this study was to investigate genomic differences between tumor samples collected from younger and older patients with colorectal...
Anirban Maitra Some interesting insights on the genomics of early versus late onset #colorectalcancer Overall similar molecular profiles but some gene specific differences (like BRAF mutations). Possible the basis for non FAP/LS young onset CRC lies outside the genome. 3d
Title not found
Med.uth.edu 3d 1 tweets
Watch out Bayer, Roche is coming for you with a rival to the tumor agnostic drug you got from Loxo
Endpts.com 3d 6 tweets
Just ahead of schedule the FDA has come through with a key approval for Genentech’s entrectinib — now headed to the market as Rozlytrek. Regulators approved the drug for ROS1-positive, metastatic non-small cell lung cancer as well as adult and...
Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism
Developmental Cell 4d 2 tweets
Pancreatic cancer arises from mutations in exocrine acinar cells. Krah et al. demonstrate that preserving acinar cell identity protects these cells from oncogenic Kras-induced tumorigenesis. Furthermore, re-expressing the acinar differentiation gene...
Anirban Maitra Who knew? Sustained expression or re-expression of the pancreatic differentiation factor Ptf1 in mice prevents & reverts #PancreaticCancer in preclinical models. New in by & the “untaggable” Charlie Murtaugh 4d
CD40 Agonist Antibodies in Cancer Immunotherapy
Annual Reviews 4d 1 tweets
CD40 is a cell-surface member of the TNF (tumor necrosis factor) receptor superfamily. Upon activation, CD40 can license dendritic cells to promote antitumor T cell activation and re-educate macrophages to destroy tumor stroma. Numerous agonist CD40...
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Anirban Maitra Bob Vonderheide in on CD40 agonists in cancer #Immunotherapy Bob is leading the multicenter trial in #PancreaticCancer using the Apexigen ab. 4d
Feds' Outdated Cancer Advice Deadly To Patients
Townhall 4d 1 tweets
When it comes to protecting yourself from cancer, don't take
Anirban Maitra I respectfully disagree with this article (most importantly the title) that insinuates recent USPSTF guidelines on #PancreaticCancer will result in deaths. 4d
In departure for NIH, Cancer Moonshot requires grantees to make papers immediately free
Science | AAAS 4d 22 tweets
Open-access requirement diverges from usual U.S. government policy
Anirban Maitra Clarifications on #CancerMoonshot #openaccess policy for Cell, Nature, Science journals (and in general) from Of note, an #openaccess line item will be permissible in NCI Moonshot grants based on this article. 4d
HPV-Related Cancers
MD Anderson Cancer Center 39d 2 tweets
No institute is better suited to help end HPV and over 150 related viruses than MD Anderson. Learn more about our Cancer Moon Shots Program here.
A clinical guide to hereditary cancer panel testing: evaluation of gene-specific cancer associations and sensitivity of genetic testing criteria in a cohort of 165,000 high-risk patients
Genetics in Medicine 4d 1 tweets
A clinical guide to hereditary cancer panel testing: evaluation of gene-specific cancer associations and sensitivity of genetic testing criteria in a cohort of 165,000 high-risk patients
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Anirban Maitra . publishes its experience of CLIA multigene testing (MGT) in 165,000 patients. With the obvious inherent FCOI, the study reiterates what academic groups have also shown - MGT picks up germline mutations that single gene testing will miss. 4d
The Immunoscore: Colon Cancer and Beyond
Clinical Cancer Research 4d 1 tweets
Tumours evolve in close interaction with their microenvironment, which encompasses a continual tension between the developing tumour and the host immune system. Clinical trials have shown that appropriate enhancement of a tumour immune response can...
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Anirban Maitra A review on stratifying tumors (particularly #ColonCancer) using the Immunoscore. By Jerome Galon (who first developed this score) & Figure - Left: Low IS, Right: High IS Cc: 4d
Kary Mullis, Inventor of the PCR Technique, Dies
The Scientist Magazine® 7d 3 tweets
The Nobel laureate was a proponent of LSD, a consultant for O.J. Simpson's legal defense, and the creator of a company that infused jewelry with celebrities' DNA.
Dose Escalation Trial of the Wee1 Inhibitor Adavosertib (AZD1775) in Combination With Gemcitabine and Radiation for Patients With Locally Advanced Pancreatic Cancer
Journal of Clinical Oncology 5d 1 tweets
PURPOSE AZD1775 (adavosertib) is an inhibitor of the Wee1 kinase. In this study, we built on our preclinical studies to evaluate the safety and efficacy of AZD1775 in combination with gemcitabine and radiation in patients with newly diagnosed...
Cancer Commons Navigating Pancreatic Cancer—The Basics
Cancercommons.org 5d 1 tweets