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Postdoctoral Fellow in Cancer Evolution - jobRxiv
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The Cancer Evolution (McFarland) Lab
A team of scientists at Case Western dedicated to understanding cancer using evolutionary theory.
Cellular co-infection can modulate the efficiency of influenza A virus production and shape the interferon response
Author summary During influenza A virus (IAV) infection, the number of virions to enter individual cells can be highly variable. Cellular co-infection appears to be common and plays an essential role in facilitating reassortment for IAV, yet little...
Malaria parasite fitness in healthy human red cells is driven by common host variation
The replication of Plasmodium falciparum malaria parasites within red blood cells (RBCs) causes severe disease in humans, especially in Africa. The influence of host erythrocyte variation on parasite replication is largely uncharted, aside from a...
The Coronavirus Is Mutating, and That’s Fine (So Far)
SARS-CoV-2 has been slowly changing in small ways, without getting more dangerous.
Alison Feder
I really like @edwardcholmes' word choice in describing mutations as "a humdrum fact of viral life"
137d
Evolutionary Rescue and Drug Resistance on Multicopy Plasmids
Bacteria often carry “extra DNA” in the form of plasmids in addition to their chromosome. Many plasmids have a copy number greater than one such that the genes encoded on these plasmids are present in multiple copies per cell. This has evolutionary...
Faculty Position in Computational Biology | Department of Computational Biology
Faculty position in Computational Biology at Cornell
Limited predictability of amino acid substitutions in seasonal influenza viruses
Seasonal influenza viruses repeatedly infect humans in part because they rapidly change their antigenic properties and evade host immune responses, necessitating frequent updates of the vaccine composition. Accurate predictions of strains...
COVID-19 Dynamics & Evolution
The COVID-19 Dynamics & Evolution series is a new initiative to bring together researchers working at the forefront of the scientific response to the pandemic. The meetings will focus on quantitative and computational approaches to studying...
Standing genetic variation fuels rapid adaptation to ocean acidification
Reductions in seawater pH are affecting marine ecosystems globally. Here, the authors describe phenotypic and genetic modifications associated with rapid adaptation to reduced seawater pH in the mussel Mytilus galloprovincialis, and suggest that...
Longitudinal linked read sequencing reveals ecological and evolutionary responses of a human gut microbiome during antibiotic treatment
Gut microbial communities can respond to antibiotic perturbations by rapidly altering their taxonomic and functional composition. However, little is known about the strain-level processes that drive this collective response. Here we characterize the...
Evolutionary Stalling in the Optimization of the Translation Machinery
Biological organisms are modular. Theory predicts that natural selection would steadily improve modules towards their performance optima up to the margin of effective neutrality. This classical theory may break down for populations evolving in the...
Bacterial warfare: Harnessing strategies bacteria use to compete with each other may lead to new antimicrobial therapies | Carver College of Medicine
University of Iowa team of researchers led by Dominique Limoli, PhD, hopes that identifying and understanding the strategies used by bacteria when they interact with one another might lead to new approaches for treating bacterial infections that...
Post-Doc position
A postdoctoral position is available in the research group offer Richard Neher at the Biozentrum of the University of Basel. Our group works on evolution of pathogenic viruses and bacteria with a focus on seasonal influenza virus, enteroviruses, and...
Linking influenza virus evolution within and between human hosts
Influenza viruses rapidly diversify within individual human infections. Several recent studies have deep-sequenced clinical influenza infections to identify viral variation within hosts, but it remains unclear how within-host mutations fare in the...
Challenging conventional wisdom on the evolution of resistance to multi-drug HIV treatment: Lessons from data and modeling.
Under the current standard of care, individuals with HIV take three antiretroviral drugs simultaneously. Triple-drug combination therapies limit HIV drug resistance evolution, because viruses resistant to a subset of the cocktail are suppressed by...
From sectors to speckles: The impact of long range migration on gene surfing
Range expansions lead to distinctive patterns of genetic variation in populations, even in the absence of selection. These patterns and their genetic consequences have been well-studied for populations advancing through successive short-ranged...
Genetic signatures of evolutionary rescue by a selective sweep
One of the most useful models in population genetics is that of a selective sweep and the consequent hitch-hiking of linked neutral alleles. While variations on this model typically assume constant population size, many instances of strong selection...