Cronutt, like a growing number of ocean mammals, developed seizures because of toxins in the water. Scientists hope the pioneering procedure he underwent this week could help.

This study describes a series of new gene-regulatory sequences that restrict expression of viral transgenes to specific interneuron subtypes, allowing for selective monitoring and manipulation of their activity from mice to humans.

2020 NAS Election

For some, university closures will delay graduation, hiring, and other critical milestones

NIH-funded research suggests zebrafish models may be efficient resource for identifying drugs for clinical use.

Thieme E-Books & E-Journals

Childhood-onset refractory epilepsies (e.g., Dravet syndrome [DS]) contribute to developmental delays, impaired quality of life, and increased mortality. We lack safe and effective antiseizure medications (ASMs) for these patients. Fenfluramine, an...

Dravet syndrome, an epileptic encephalopathy affecting children, largely results from heterozygous loss-of-function mutations in the brain voltage-gated sodium channel gene SCN1A. Heterozygous Scn1a knockout (Scn1a +/−) mice...