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Pseudomonas aeruginosa PA14 biofilms produce R-bodies, extendable protein polymers with roles in host colonization and virulence
reb genes code for R-bodies: large, extendable polymers that are known for their roles in obligate endosymbioses. In the non-endosymbiotic pathogen Pseudomonas aeruginosa, reb homologues are part of a cluster found in virulent strains. Here, we...
Compost spatial heterogeneity promotes evolutionary diversification of a Bacterium
Spatial resource heterogeneity is expected to be a key driver for the evolution of diversity. However, direct empirical support for this prediction is limited to studies carried out in simplified lab...
Gene Loss and Acquisition in Lineages of Pseudomonas aeruginosa Evolving in Cystic Fibrosis Patient Airways
Genome analyses have documented that there are differences in gene repertoire between evolutionary distant lineages of the same bacterial species; however, less is known about microevolutionary dynamics of gene loss and acquisition within bacterial...
Three-dimensional biofilm growth supports a mutualism involving matrix and nutrient sharing
Life in a three-dimensional structure such as a biofilm is typical for many bacteria, yet little is known about how strains with different genotypes interact in this context. Here, to systematically explore gene knockdowns across various...
The evolution of tit-for-tat in bacteria via the type VI secretion system
Game theory has contributed much to the understanding of social evolution. In an elegant combination of experimental tests and modelling, this study suggests that when bacteria face intense competition, repeated retaliation outcompetes a single...
BBSRC White Rose DTP Studentship - The modular genome: how plasmids mediate major transitions in Rhizobium lifestyles at University of Sheffield on FindAPhD.com
PhD Project - BBSRC White Rose DTP Studentship - The modular genome: how plasmids mediate major transitions in Rhizobium lifestyles at University of Sheffield, listed on FindAPhD.com
Treated wastewater irrigation promotes the spread of antibiotic resistance into subsoil pore-water
In the present study, we investigated the impact of treated wastewater (TWW) irrigation on the prevalence of antibiotic resistance genes (ARGs) in sub…
'He was a father figure': loved ones remember victims of UK's Covid second wave
Friends and family pay tribute to an engineer in Blackpool, a music legend in Liverpool and a Rotherham taxi driver
Michael Brockhurst
Tragic news. Hambi was a true Liverpool legend. He was incredibly welcoming to us when we arrived in there in the mid-00s, introducing Becs to the local arts scene. They later travelled to India together, a life-changing experience for her. So sad.
86d
Piggybacking on niche-adaptation reduces the cost of multidrug resistance plasmids
The persistence of plasmids in bacterial populations represents a puzzling evolutionary problem with serious clinical implications due to their role in the ongoing antibiotic resistance crisis. Recently, major advancements have been made towards...
Limited and strain-specific transcriptional and growth responses to acquisition of a multidrug resistance plasmid in genetically diverse Escherichia coli lineages
Multi-drug resistant (MDR) Escherichia coli are a major global threat to human health, wherein multi-drug resistance is primarily spread by MDR plasmid acquisition. MDR plasmids are not widely distributed across the entire E. coli species, but...
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Michael Brockhurst
New preprint 🥳🥳
Limited + strain-specific transcriptional and growth responses to acquisition of a multidrug resistance plasmid in genetically diverse E. coli lineages
By @StevenJDunn and @qwertkwert with @alanmcn1
87d
The general stress response of Staphylococcus aureus promotes tolerance of antibiotics and survival in whole human blood | Microbiology Society
Staphylococcus aureus
is a frequent cause of invasive human infections such as bacteraemia and infective endocarditis. These infections frequently relapse or become chronic, suggesting that the pathogen has mechanisms to tolerate the twin threats of...
Synthetic gene-regulatory networks in the opportunistic human pathogen Streptococcus pneumoniae
Streptococcus pneumoniae is a major human pathogen responsible for enormous global morbidity and mortality. Despite this, the pneumococcus makes up part of the commensal nasopharyngeal flora. How the pneumococcus switches from this commensal to...
Mutational meltdown of microbial altruists in Streptomyces coelicolor colonies
In colonies of the filamentous multicellular bacterium Streptomyces coelicolor, a sub-population of cells arise that hyper-produce metabolically costly antibiotics, resulting in a division of labor that maximizes colony fitness. Because these cells...
The evolution of coexistence from competition in experimental co-cultures of Escherichia coli and Saccharomyces cerevisiae
Microbial communities are comprised of many species that coexist on small spatial scales. This is difficult to explain because many interspecies interactions are competitive, and ecological theory predicts that one species will drive the extinction...
Soil Viruses Are Underexplored Players in Ecosystem Carbon Processing
Rapidly thawing permafrost harbors ∼30 to 50% of global soil carbon, and the fate of this carbon remains unknown. Microorganisms will play a central role in its fate, and their viruses could modulate that impact via induced mortality and metabolic...
Britain faces a second Covid-19 peak at CHRISTMAS, SAGE adviser warns
Professor John Edmunds, an epidemiologist at the London School of Hygiene & Tropical Medicine, told MPs that the three-tier lockdown system will only slow down the UK's outbreak and not shrink it.
How do interactions between mobile genetic elements enhance microbial community resilience? at University of Liverpool on FindAPhD.com
PhD Project - How do interactions between mobile genetic elements enhance microbial community resilience? at University of Liverpool, listed on FindAPhD.com
Cryptic or Silent? The Known Unknowns, Unknown Knowns, and Unknown Unknowns of Secondary Metabolism
Microbial natural products, particularly those produced by filamentous Actinobacteria , underpin the majority of clinically used antibiotics. Unfortunately, only a few new antibiotic classes have been discovered since the 1970s, which has...