Chris Barbieri
Urologic Oncologist, #prostatecancer translational researcher, husband, father, Eagles fan. Views my own. RT≠E
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Robust foreground detection in somatic copy number data
Sensitive detection of somatic copy number alterations (SCNA) in cancer genomes is confounded by "waviness" in read depth data. We present dryclean, a signal processing algorithm to optimize SCNA detection in whole genome (WGS) and targeted...
Cistrome Partitioning Reveals Convergence of Somatic Mutations and Risk Variants on Master Transcription Regulators in Primary Prostate Tumors
Mazrooei et al. show that somatic SNVs are enriched in cistromes of master transcription
regulators in prostate cancers but not in adjacent normal tissues. Few SNVs alter
CREs but collectively target essential transcription regulators.
The Urology Care Foundation — trusted online resources in an era of misinformation
The Internet can be a valuable resource for patients, but it is also a minefield of misinformation and hidden bias. The Urology Care Foundation is attempting to mitigate this flood of inaccurate information by providing high-quality online resources...
E.P.A. to Tighten Limits on Science Used to Write Public Health Rules
A new agency rule would restrict the science that can be used in drafting health regulations by requiring researchers to turn over confidential health data.
Potted plants do not improve indoor air quality: a review and analysis of reported VOC removal efficiencies
Potted plants do not improve indoor air quality: a review and analysis of reported VOC removal efficiencies
Genomics and risk stratification in high-risk prostate cancer
Clinical and pathological risk grouping defines management in localized prostate cancer. Recent work suggests men with high-risk prostate cancer can be further subdivided into three risk groups (favourable high-risk, standard high-risk and...
Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer
Hypermethylation of <i>FOXA1</i> and allelic loss of <i>PTEN</i> drive squamous differentiation and promote heterogeneity in bladder cancer
Young Investigator Award - Class of 2019
The PCF Young Investigator Award-Class of 2019 recipients are: 2019 National Cancer Institute – PCF Young Investigator Award Remi Adelaiye-Ogala, PhD National Cancer Institute (NCI) Mentors: Kathleen Kelly, David VanderWeele Investigating alteration...
A rectal cancer organoid platform to study individual responses to chemoradiation
Rectal cancer organoids retain the pathological features of matched patient tumors and recapitulate clinical responses to chemoradiation.
Publish houses of brick, not mansions of straw
Papers need to include fewer claims and more proof to make the scientific literature more reliable, warns William G. Kaelin Jr.
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization
Gomes et al. reveal metastatic stimuli reduce histone H3.1/H3.2 deposition on chromatin
by suppressing the CAF-1 complex in breast and NSCLC cancer cells, leading to increased
incorporation of non-canonical histone H3.3, which in turn induces...
KLF4 is involved in the organization and regulation of pluripotency-associated three-dimensional enhancer networks
Di Giammartino, Kloetgen, Polyzos, Liu et al. probe chromatin organization, enhancer status and transcriptional changes and show that KLF4 acts as a transcriptional regulator and chromatin organizer during induced pluripotent stem cell reprogramming...
We Need More Doctors Who Are Scientists
It’s in everyone’s benefit if physicians participate in research.
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Chris Barbieri
We Need More Doctors Who Are Scientists
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Presidential Message on National Prostate Cancer Awareness Month
Throughout National Prostate Cancer Awareness Month, we reaffirm our commitment to bring attention to prostate cancer and to better understand the risk factors and early symptoms of this horrible disease. We also renew our Nation’s pledge to...
Join the Team
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Chris Barbieri
The Barbieri Lab is hiring!
Looking for wet-lab and computational post-docs to work on prostate cancer molecular subtypes, transcriptional control, epigenomics, ubiquitin ligases, drug discovery...and anything else we stumble into...
barbierilab.com/join-the-team
Please RT!
110d
Saving the Endangered Physician-Scientist — A Plan for Accelerating Medical Breakthroughs | NEJM
Perspective from The New England Journal of Medicine — Saving the Endangered Physician-Scientist — A Plan for Accelerating Medical Breakthroughs