Chris Barbieri
Urologic Oncologist, #prostatecancer translational researcher, husband, father, Eagles fan. Views my own. RT≠E
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Rachel Brenner, PhD on TikTok
Last line is my favorite. #phdlife #phdstudent #research #academia #sketchcomedy
Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer
Zhang et al. find that cancer-associated fibroblasts promote antiandrogen resistance
in prostate cancer by secreting NRG1 to activate HER3 signaling in prostate cancer
cells. Blockade of the NRG1/HER3 axis can re-sensitize prostate cancer models to...
Jobs at Fred Hutchinson Cancer Research Center
Search for job openings at Fred Hutch and Seattle Cancer Care Alliance including faculty and staff positions, and postdoctoral fellowships.
Hsieh Lab
The Hsieh Lab at Fred Hutchinson Cancer Research Center aims to to comprehensively delineate the fundamental role of mRNA translation in normal cell physiology, cancer etiology, and cancer progression.
The clonal evolution of metastatic colorectal cancer
Tumor heterogeneity and evolution drive treatment resistance in metastatic colorectal cancer (mCRC). Patient-derived xenografts (PDXs) can model mCRC biology; however, their ability to accurately mimic human tumor heterogeneity is unclear. Current...
Human Prostate Cancer-Associated Macrophage Subtypes with Prognostic Potential Revealed by Single-cell Transcriptomics
Macrophages in the tumor microenvironment are causally linked with prostate cancer development and progression, yet little is known about their composition in neoplastic human tissue. By performing single cell transcriptomic analysis of human...
Lineage reversion drives WNT independence in intestinal cancer
The WNT pathway is a fundamental regulator of intestinal homeostasis and hyperactivation of WNT signaling is the major oncogenic driver in colorectal cancer (CRC). To date, there are no described mechanisms that bypass WNT dependence in intestinal...
AUA 2020 Annual Meeting
Chris Barbieri
Congrats to @jeshoag and Peter Cai @WCMurology
for another AUA Best Poster MP64-07: Age-Dependent Prevalence of Prostate Cancer Genomic Subtypes Predicted by Inverse Probability Weighting cdmcd.co/kp5DGy #AUAVirtualSci @WCM_PCa_SPORE
61d
AUA 2020 Annual Meeting
1
Chris Barbieri
Congrats to Peter Cai @WCMurology for AUA Best Poster in Prostate Cancer: Basic Research & Pathophysiology - MP51-01: Prevalence of Collision Tumors in Prostate Cancer as a Model for Intrafocal Genomic Heterogeneity cdmcd.co/wYx8pp #AUAVirtualSci @WCM_PCa_SPORE @EngIPM
61d
Phase and context shape the function of composite oncogenic mutations
Composite mutations, of two or more nonsynonymous somatic mutations in the same cancer-associated gene, are present in nearly one in four human tumours.
Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression
The role of long non-coding RNAs (lncRNAs) in metastatic colorectal cancer (mCRC) and treatment resistance is unclear. Here, the authors use transcriptome sequencing of matched normal, primary, and metastatic CRC tissues to discover and validate...
Cancer and COVID-19 — potentially deleterious effects of delaying radiotherapy
Radiotherapy can be safely delivered during the coronavirus disease 2019 (COVID-19) pandemic, often through use of hypofractionated regimens, which minimize the number of visits to treatment centres while also avoiding potentially detrimental delays...
Study Reveals Molecular Landscape of Enlarged Prostates, Suggests Treatment Strategy
Growth of the prostate is exceptionally common in aging men, leading to problems with urination. This overgrowth is not a tumor-like condition driven by gene mutations, and may be treatable in many cases with a class of drugs called mTOR inhibitors,...
No evidence that androgen regulation of pulmonary TMPRSS2 explains sex-discordant COVID-19 outcomes
The recent emergence of SARS-CoV-2 and the subsequent COVID-19 pandemic have posed a public health crisis. Higher morbidity and mortality of men with COVID-19 may be explained by androgen-driven mechanisms. One such proposed mechanism is androgen...
COVID-19 Update from Dr. Smith: 4/19/20
Each day during the COVID-19 crisis, Dr. Craig Smith, Chair of the Department of Surgery, sends an update to faculty and staff about pandemic response and priorities. Stay up to date with us. Dear Colleagues,
Compassionate Use of Remdesivir for Patients with Severe Covid-19 | NEJM
Original Article from The New England Journal of Medicine — Compassionate Use of Remdesivir for Patients with Severe Covid-19
Covid vs. US Daily Average Cause of Death
A Flourish data visualisation by Alex Estrella