David SteensmaThose of us who see patients are regularly reminded of our work's purpose. But not everyone who works at large med centers has patient contact. Consider reminding admins and other behind-the-scenes folks why what they do greatly matters, too. @DanaFarber
Research Interests: Comparative Pathology, Retroviruses
David SteensmaIn the late 1960s, the heyday of the “viruses cause cancer” concept, scientist Murray Gardner and his colleagues in the Virus Cancer Program @KeckMedUSC were working on oncogenic retroviruses of wild mice and domestic cats. /9 He later went to @ucdavis
A small colony of feral mice from California continues to flourish in spite of virulent epizootic of pathological retrovirus. Epidemiological and gene…
David SteensmaOne colony of feral mice that Gardner and colleagues caught on a farm near Lake Casitas – a brown mouse colony called "Cas-Br-M" – curiously seemed immune to pathological murine leukemia viruses./10
David Steensma~5 yrs ago I heard a fascinating talk at @WellesleyLib about the history of eyeglasses by David Fleishman, a retired ophthalmologist from the Boston area (Brockton). His website is antiquespectacles.com There have been a lot of peculiar eyeglass ideas over the centuries!/17
WebPathology is a free educational resource with 8234 high quality pathology images of benign and malignant neoplasms and related entities.
David Steensma19th c. French & British pathologists used terms "waxy" or "lardaceous" to describe tissue changes of amyloid. The classic "sago spleen" is named after a tapioca-like palm starch. (What is it with pathologists and food metaphors?!) This yummy image is from Webpathology.compic.twitter.com/KEHMQZPJYv
Article Citation: David P. Steensma (2001) “Congo” Red. Archives of Pathology & Laboratory Medicine: February 2001, Vol. 125, No. 2, pp. 250-252.
David SteensmaI can't imagine anyone would want to read more about the history of Congo Red, but just in case, here is a link to an article I wrote in 2001 about this history based in part on too much time spent trawling through old German industrial archives
This is "Steve Zeldenrust Faith Story, Nov. 18, 2018" by Autumn Ridge Church on Vimeo, the home for high quality videos and the people who love them.
David SteensmaThe preferred way to confirm what type of amyloid is present is now mass spectrometry. My late lab office-mate @MayoClinic Steve Zeldenrust was developing such protocols when he developed sarcoma. (An aside: a moving video that Steve made for his church
Six months after Brexit, the world of a Times reporter’s children remains inclusive, but she finds a changing Britain and feels her German heritage more than before.
David SteensmaAnyway - Congo Red, like many other aniline dyes, immediately started being used for histology. But it wasn't particularly useful until on 1922 a young German pathologist, Hans Herman Bennhold, discovered it binds to amyloid. His granddaughter wrote this
British scientist Sir Peter Ratcliffe shares the 2019 Nobel Prize for physiology or medicine.
David SteensmaAmused that @bbc chose an image of a scuba diver to illustrate story about cellular hypoxia sensing... if diving goes well, there is no hypoxia! How cells sense oxygen wins Nobel prize
David SteensmaThe "Prussian" part comes from correspondence involving Gottfriend Leibniz, then head of the Prussian Academy of Sciences. As "Parisian blue" the same substance became a popular pigment in the art world, e.g. used in this famous painting by #Hokusai./19
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David SteensmaIn 2008, an International Working Group led by Ghulam Mufti @KingsCollegeNHS and John Bennett decided ring sideroblasts were "erythroblasts in which there are a minimum of 5 siderotic granules covering at least a third of the nuclear circumference." /8
Dana-Farber Cancer Institute has a new visual identity, modernizing its logo with a vivid blue and gold palette. Our new logo says that Dana-Farber will continue to set the standard for lifesaving cancer research and care into the future.
Largest single philanthropic commitment to MDS research and care in Dana-Farber historyCredit: Dana-Farber Cancer Institute A $5 million gift from the Edward P. Evans Foundation will create the Edward P. Evans Center for Myelodysplastic Syndromes (MD
David SteensmaExcited to announce creation of The Edward P. Evans Center for MDS @DanaFarber! This tremendous gift honoring Mr. Evans' legacy will allow us to redouble our collective efforts to understand #MDS biology & improve lives of people with MDS @EdwardPEvansFdn
A phase 3 trial of Celgene’s acute myeloid leukemia maintenance therapy CC-486 has met its primary endpoint. Patients who took the cytidine nucleoside analog lived longer than their peers on placebo.
David SteensmaMaintenance studies in #AML are difficult to conduct - lots of dropouts, hard to control for transplant, etc. So good for @Celgene & investigators/patients for completing this one, and with a positive OS result. Celgene's phase 3 AML test chalks up a win