The common view is that T-lymphocytes activate telomerase, a DNA polymerase that extends telomeres at chromosome ends, to delay senescence. We show that independently of telomerase, T cells elongate telomeres by acquiring telomere vesicles from...

Effective anticancer immunosurveillance after oncolytic viral infection is often hindered by the defective metabolic function of tumor-infiltrating lymphocytes (TILs). A recent paper by Rivadeneira et al. demonstrates that intratumoral delivery of...

Metabolic insufficiency is a major barrier for antitumor immunity. Rivadeneira et al. demonstrate that engineering an oncolytic virus to express a metabolic modulator, in this case the adipokine leptin, improves T cell metabolic function in the...