When COVID-19 burst on to the scene, tests quickly showed that the everyone was susceptible - no pre-existing antibodies were found that bound to the SARS-CoV-2 virus. This led to dire predictions that over 80% of the population might eventually...
The recent implosion of the Surgisphere data papers has been big news. It included one that purported to show no benefit (and actual harm) from hydroxychloroquine treatment, and even more harm when combined with azithromycin - but since the authors...
Derek LoweI am officially done with talking about hydroxychloroquine on my site. Unless something dramatic happens, I see no need to revisit the topic of what appears to be an ineffective treatment for the coronavirus.
Most readers will have heard that this paper appeared in the NEJM late yesterday afternoon: it's something that we haven't had so far, an actual randomized, double-blinded, placebo-controlled hydroxychloroquine trial. This one was for post-exposure...
Derek LoweLate yesterday afternoon we got a blinded, placebo-controlled trial of hydroxychloroquine for prophylaxis against coronavirus infection. It found no effect, but it won't stop the arguments
This randomized trial compares the effects of convalescent plasma therapy with standard care vs standard care alone on time to clinical improvement among patients with severe or life-threatening COVID-19 disease in China.
Let's circule back to remdesivir. We already have the results of the remdesivir Phase II trial that led to its Emergency Use Authorization by the FDA. But now come the first Phase III results, and it's safe to say that they're not making anyone...
Derek LoweThe latest news on coronavirus therapies: what looks like solid improvement in severe patients after anti-IL-6 treatment, and some not-good not-bad data on remdesivir.
So we have a very strange situation with some recent publications, one that deserves a closer look. The ones I refer to are the recent Lancet retrospective study on hydroxychloroquine use (blogged about here), one of the hospital data studies on the...
Derek LoweSurgisphere has published several papers based on what they say is a massive electronic medical records database. But there are some massive questions about it, and about the way they've dealt with the numbers
It feels strange to be writing about biomedicine, even about a terrible pandemic, under the current circumstances. I was six years old in 1968 and was thus largely spared that year's events, so 2020 is now the year that in which I'm most fearful...
Derek LoweBiomedical blogging resumes later today. First, some commentary, though