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Adoptive immunotherapy with CB following chemotherapy for patients with refractory myeloid malignancy: chimerism and response | Blood Advances | American Society of Hematology
Key Points. CB-derived adoptive cell therapy is a feasible and efficacious therapeutic approach for patients with refractory AML.Treatment response depends on
Study shows disparities in access to molecular diagnostics for colorectal cancer
Although testing for microsatellite instability and mismatch repair deficiency has increased for advanced colorectal cancer, substantial gaps in testing remain among certain patient groups, according to study results.The results, presented at...
Family history of breast cancer in men with non- BRCA male breast cancer: implications for cancer risk counseling
The role of genetic predisposition in male breast cancer (MBC) patients who test negative for a BRCA mutation is unclear. The aim of this study is to define the association between MBC and family history of breast cancer in patients without...
Genome-Wide Somatic Alterations in Multiple Myeloma Reveal a Superior Outcome Group
PURPOSE Multiple myeloma (MM) is accompanied by heterogeneous somatic alterations. The overall goal of this study was to describe the genomic landscape of myeloma using deep whole-genome sequencing (WGS) and develop a model that identifies patients...
Efficacy of folinic acid rescue following MTX GVHD prophylaxis: results of a double-blind, randomized, controlled study | Blood Advances | American Society of Hematology
Key Points. FA rescue following MTX GVHD prophylaxis does not decrease regimen-related toxicity or affect transplantation outcomes.
Modern management of splenomegaly in patients with myelofibrosis
Myelofibrosis (MF) is a chronic myeloproliferative neoplasm which can lead to massive splenomegaly secondary to extramedullary hematopoiesis. Patients frequently exhibit debilitating symptoms including pain and early satiety, in addition to cellular...
Assessing the Impact of Lockdown: Fresh Challenges for the Care of Haematology Patients in the COVID‐19 Pandemic
The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.
Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHD
Haematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for several haematological malignancies. Improvements in HSCT methodologies have considerably reduced treatment-related morbidity and mortality, thus broadening...
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Haploidentical BMT for severe aplastic anemia with intensive GVHD prophylaxis including posttransplant cyclophosphamide | Blood Advances | American Society of Hematology
Key Points. Bone marrow transplantation with posttransplantation CY in severe aplastic anemia results in rapid hematopoietic reconstitution.Rates of graft-vers
Haploidentical hematopoietic stem cell transplantation in aplastic anemia: a systematic review and meta-analysis of clinical outcome on behalf of the severe aplastic anemia working party of the European group for blood and marrow transplantation (SAAWP of
Haploidentical hematopoietic stem cell transplantation in aplastic anemia: a systematic review and meta-analysis of clinical outcome on behalf of the severe aplastic anemia working party of the European group for blood and marrow transplantation...
Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma
The mechanisms of action of proteasome inhibitors (PI) in multiple myeloma (MM) treatment are not fully elucidated. Here, the authors use unbiased phosphoproteomics in PI-treated MM and show increased phosphorylation of splicing-associated proteins,...