Jibran Khokhar
Neuropsychopharmacologist; co-occurring addiction/mental illness @queensu/@UofT/@Dartmouth Assist. Professor @UofG @OntVetCollege. PI @JKhokharLab
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Dopamine neuron ensembles signal the content of sensory prediction errors
Dopamine neurons respond to errors in predicting value-neutral sensory information. These data, combined with causal evidence that dopamine transients support sensory-based associative learning, suggest that the dopamine system signals a...
Associations between adolescent cannabis use frequency and adult brain structure: A prospective study of boys followed to adulthood
Few studies have tested the hypothesis that adolescent cannabis users show structural brain alterations in adulthood. The present study tested associa…
Jibran Khokhar
Associations between adolescent cannabis use frequency and adult brain structure: A prospective study of boys followed to adulthood - ScienceDirect
16d
Why flavored vape products may be attractive: Green apple tobacco flavor elicits reward-related behavior, upregulates nAChRs on VTA dopamine neurons, and alters midbrain dopamine and GABA neuron function
While nicotine is the primary addictive component in tobacco products, additional flavors have become a concern with the growing popularity of electro…
8 teens hospitalized with 'severe lung damage' from vaping — leading expert says e-cig use is 'not without health effects'
Experts in Wisconsin are speaking out after eight high school kids were hospitalized from vaping. “Vaping in teenagers is causing significant damage,” the hospital's chief medical officer said. “We want that message to be loud and clear.”
A Paranigral VTA Nociceptin Circuit that Constrains Motivation for Reward
Nociceptin and its receptor are widely distributed throughout the brain in regions associated with reward behavior, yet how and when they act is unkno…
Identification of a neurocircuit underlying regulation of feeding by stress-related emotional responses
Eating disorders are often comorbid with emotional and psychiatric symptoms yet the underlying neural circuits are poorly understood. Here, the authors report that projections from the paraventricular hypothalamus to the ventral part of the lateral...
High-Frequency Activation of Nucleus Accumbens D1-MSNs Drives Excitatory Potentiation on D2-MSNs
Reward outcomes depend on the stimulation protocol used to activate nucleus accumbens
medium spiny neuron (MSN) subtypes. In this issue of Neuron, Francis et al. demonstrate
rebalanced MSN subtype excitation driven by high-frequency stimulation and...
Conditioned place preference using opiate and stimulant drugs: A meta-analysis
A meta-analysis was conducted on the data obtained from published articles that have used the conditioned place preference (CPP) paradigm to assess th…
Infralimbic Estradiol Enhances Neuronal Excitability and Facilitates Extinction of Cocaine Seeking in Female Rats via a BDNF/TrkB Mechanism
Women are more susceptible to developing cocaine dependence than men, but paradoxically, are more responsive to treatment. The potent estrogen, 17β-estradiol (E2), mediates these effects by augmenting cocaine seeking but also promoting extinction of...
Nabiximols for the Treatment of Cannabis Dependence
This randomized clinical trial examines the safety and efficacy of nabiximols, an oromucosal tetrahydrocannabinol-cannabidiol medication vs placebo, in the treatment of adults with cannabis dependence.
Jibran Khokhar
Nabiximols for the Treatment of Cannabis Dependence: A Randomized Clinical Trial | Psychiatry | JAMA Internal Medicine | JAMA Network
17d
New report looks at the state of cannabis and mental health research
Canada has an edge when it comes to future research
Comparative Efficacy and Acceptability of Psychotherapies for Pediatric Acute Anxiety Disorders
This network meta-analysis compares and ranks the different types of psychotherapies and the different ways of delivering psychological treatments for anxiety disorders in children and adolescents.
Clozapine and Evidence-Based Psychopharmacology for Schizophrenia
On treatment of schizophrenia with medication, evidence-based guidelines agree on definitive recommendations for only a small number of issues: antipsychotic dr
Stress, craving and mood as predictors of early dropout from opioid agonist therapy
Treatment with opioid agonists is effective for opioid use disorder, but early discontinuation of treatment is a major obstacle to success. Intensive …
CYP2D6-guided Opioid Therapy Improves Pain Control in CYP2D6 Intermediate and Poor Metabolizers: A Pragmatic Clinical Trial
These data support the potential benefits of CYP2D6-guided pain management.
Its complicated: The relationship between alcohol and microglia in the search for novel pharmacotherapeutic targets for alcohol use disorders
Alcohol use disorder (AUD) is a chronic relapsing disorder with wide-ranging health consequences. Alcohol targets the central nervous system producing…