Lysine methylation of transcription factors in cancer
Einstein EpigenomicsI knew this day would come. Prepare to get your heads melted, #epigenetics researchers.
Transcription factors can be post-translationally modified.
These PTMs can affect their function.
Lysine methyltransferase inhibitors may affect TF PTMs.
The government repeatedly claims exiting the EU is 'the will of the people'. We need to put a stop to this claim by proving the strength of public support now, for remaining in the EU. A People's Vote may not happen - so vote now.
Epigenome-wide association studies represent one means of applying genome-wide assays to identify molecular events that could be associated with human phenotypes. The epigenome is especially intriguing as a target for study, as epigenetic regulatory...
Scientists are often steered by common convention, funding agencies, and journal guidelines into a hypothesis-driven experimental framework, despite Isaac Newton’s dictum that hypotheses have no place in experimental science. Some may think that...
Einstein EpigenomicsI suggest that anyone writing a grant proposal or just thinking about starting a scientific project read this thoughtful piece by @davidjglassMD.
How we get trapped by hypothesis-driven science, big science issues, and the question/model alternative.
Einstein EpigenomicsWell done to @ColumbiaMed for this tough, public self-examination in @TheLancet. A lot of work to do, plenty of potential to inspire other institutions to do likewise.
Achieving women's equity in academic medicine: challenging the standards
DNA samples from elderly or frail survivors should be ‘banked’ for future identification
Einstein EpigenomicsThis is a perfectly reasonable, well informed request. What DNA biobanking facilities exist in Ireland?
Would a DNA testing company be willing to do this as a philanthropic gesture?
Tuam home survivors want DNA samples to be taken
Hypusine is formed post-translationally from lysine and is found in a single cellular
protein, eukaryotic translation initiation factor-5A (eIF5A), and its homolog eIF5A2.
Biosynthesis of hypusine is a two-step reaction involving the enzymes...
Why it’s so hard to see our own ignorance, and what to do about it.
Einstein EpigenomicsIn an #epigenetic association study, we assume the null hypothesis that everything we’re finding is due to confounding effects, and work to prove otherwise, right?
Is this not the same for every experiment? Don’t we call this the scientific method?