Directed DNA methylation on N6-adenine (6mA), N4-cytosine (4mC), and C5-cytosine (5mC) can potentially increase DNA coding capacity and regulate a variety of biological functions. These modifications are relatively abundant in bacteria, occurring in...
Einstein EpigenomicsI just finished a chapter in my book on #epigenetics, a 22,281 word beast on molecular mechanisms. It nearly broke me.
I don’t want any whining that I didn’t talk enough about your favourite mechanism. I even included 6mA which may not even exist
The molecular mechanisms underlying the dynamic nature of the female brain structure and function remain poorly understood. Here the authors characterise chromatin organization in the mouse female ventral hippocampus, finding it fluctuates with the...
DNA microscopy is an optics-free imaging method based on chemical reactions and a
computational algorithm to infer spatial organization of transcripts while simultaneously
preserving full sequence information.
Einstein EpigenomicsThis DNA microscopy paper is really extraordinary. Tour de force stuff.
DNA Microscopy: Optics-free Spatio-genetic Imaging by a Stand-Alone Chemical Reaction
Einstein Epigenomics@ewanbirney Gianpiero Cavalleri’s popgen study of Irish travellers (mincéirí) was, I thought, pretty thoughtful and sensitive, and helped to shape the debate positively about their ethnic status in Ireland #minceir
Adipose tissue is an important endocrine organ with a role in many cardiometabolic
diseases. It is comprised of a heterogeneous collection of cell types that can differentially
impact disease phenotypes. Cellular heterogeneity can also confound...
The LifeLong Research Study at Albert Einstein College of Medicine. 2 likes. The LifeLong Research Study in the Institute of Aging Research and Center for Epigenomics at Albert Einstein College of...
Einstein EpigenomicsPlease retweet: The Facebook page for the LifeLong study.
Looking for volunteers so we can study #epigenetics and ageing in your T lymphocytes.
The LifeLong Research Study at @EinsteinMed
Dorothy Bishop describes how threats to reproducibility, recognized but unaddressed for decades, might finally be brought under control.
Einstein EpigenomicsIn #epigenetics, the fifth horseman is what I call the ghost hypothesis. Framing the study with a meaningless statement like “we looked for the epigenetic mechanism”. Any result then works.
Rein in the four horsemen of irreproducibility
Lysine methylation of transcription factors in cancer
Einstein EpigenomicsI knew this day would come. Prepare to get your heads melted, #epigenetics researchers.
Transcription factors can be post-translationally modified.
These PTMs can affect their function.
Lysine methyltransferase inhibitors may affect TF PTMs.
The government repeatedly claims exiting the EU is 'the will of the people'. We need to put a stop to this claim by proving the strength of public support now, for remaining in the EU. A People's Vote may not happen - so vote now.
Epigenome-wide association studies represent one means of applying genome-wide assays to identify molecular events that could be associated with human phenotypes. The epigenome is especially intriguing as a target for study, as epigenetic regulatory...