Eric Topol
physician-scientist, author, editor. My new book is #DeepMedicine
Last synced from Twitter 19m ago
Lifestyle Science and Health News: Neglecting Major Health Problems in Favor of Minor Uncertain Exposures
Jamanetwork.com 19h 8 tweets
In this Viewpoint, John Ioannidis discusses the proliferation of observational studies and news about lifestyle exposures that have trivial and often imprecise associations with meaningful public health outcomes, and proposes ways scientific...
Eric Topol "Much of the [health] broadcasted information [to the public] is not only disproportional, but also uncertain or even false." The confusing minutiae w/ disproportionate rankings by John Ioannidis 19h
Putting the ‘I’ in science
Nature.com 47h 3 tweets
Chris Lintott’s chronicle of the booming citizen-science project Zooniverse is inspirational, finds Michael West.
Eric Topol Here's an #AI switch😉:"exploit the human #brain’s ability to recognize patterns, or to spot unusual features in data that even the most sophisticated computer algorithms can miss." #CitizenScience review of 's new book 20h
A systems approach to clinical oncology uses deep phenotyping to deliver personalized care
Nature Reviews Clinical Oncology 24h 1 tweets
A systems biology-based approach incorporating multiscale, longitudinal measurements (from single-cell analyses to whole-body monitoring) would help to decipher the complexity of cancer and would facilitate the development of personalized therapies....
Eric Topol If only we could learn the most from each person (deep phenotyping), we could help transform the future of #cancer An astute perspective from 24h
Prediction of lung cancer risk at follow-up screening with low-dose CT: a training and validation study of a deep learning method
The Lancet Digital Health 25h 2 tweets
DeepLR recognises patterns in both temporal and spatial changes and synergy among changes in nodule and non-nodule features. DeepLR scores could be used to accurately guide clinical management after the next scheduled repeat screening CT scan.
Eric Topol Predicting 3-year risk of lung #cancer from deep learning #AI of 2 CT scans and clinical data by Peng Huang w/ and many Canadian colleagues 25h
Deep Neural Networks Improve Radiologists’ Performance in Breast Cancer Screening - IEEE Journals & Magazine
Ieeexplore.ieee.org 26h 2 tweets
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Eric Topol Deep learning #AI of > 1 M mammograms: "a hybrid model, averaging the probability of malignancy predicted by a radiologist with a prediction of our neural network, is more accurate than either of the two separately." by 25h
Why skimping on sleep makes your brain crave sweets
Science | AAAS 47h 3 tweets
The secret lies in the way your brain makes sense of scents
Eric Topol More on how #sleep skimping shifts smell and #diet 41h
Technological challenges and milestones for writing genomes
Science 44h 3 tweets
Engineering biology with recombinant DNA, broadly called synthetic biology, has progressed tremendously in the last decade, owing to continued industrialization of DNA synthesis, discovery and development of molecular tools and organisms, and...
Eric Topol A step ahead: while most of us are still trying to read genomes, they're planning the writing phase by Nili Ostrov and the synthetic #genomics gurus 44h
Adaptive archaic introgression of copy number variants and the discovery of previously unknown human genes
Science 44h 7 tweets
As they migrated out of Africa and into Europe and Asia, anatomically modern humans interbred with archaic hominins, such as Neanderthals and Denisovans. The result of this genetic introgression on the recipient populations has been of considerable...
Eric Topol Filing under S large CNVs originating in archaic hominins and introgressed into modern humans 44h
How to reveal a country’s sense, over the years, of its own well-being
The Economist 45h 2 tweets
Read its books. By computer
Eric Topol As I anticipated, is on this one :-) 45h
Data-labelling startups want to help improve corporate AI
The Economist 46h 1 tweets
A clutch of firms is generating the feedstock for machine-learning algorithms: tagged data
Eric Topol The bottleneck of deep neural networks is labeled datasets. highlights some of the companies working on solving that: "an industry is popping up to help" #AI 46h
Circulating Tumor DNA Analyses as Markers of Recurrence Risk and Therapy Benefit in Colon Cancer
Jamanetwork.com 47h 6 tweets
This multicenter cohort study assesses whether serial postsurgical and postchemotherapy analyses of circulating tumor DNA levels could provide a real-time indication of adjuvant therapy efficacy in patients with stage III colon cancer.
Eric Topol The 1st prospective study w/ cell-free tumor DNA biomarker as a pre-specified primary end point (albeit small N, only 15 genes assessed) "Is the patient cured?" insightful editorial et al H Burke and 47h
Is the Patient Cured?
Jamanetwork.com 47h 1 tweets
After administering a therapy with curative intent, patients and physicians have 1 key question in mind: is the cancer cured? Unfortunately, because of the limi
Eric Topol The 1st prospective study w/ cell-free tumor DNA biomarker as a pre-specified primary end point (albeit small N, only 15 genes assessed) "Is the patient cured?" insightful editorial et al H Burke and 47h
Cascades of Care After Incidental Findings in a US National Survey of Physicians
Jamanetwork.com 3d 6 tweets
This survey study estimates the national frequency and consequences of cascades of care after incidental findings using results from a national survey of US physicians.
Eric Topol "Incidental findings ...caused harm to patients and themselves." Results of a national physician survey ("cascades of care") by and colleagues H/T (origin of term "incidentaloma") 49h
20-Year Follow-up of Statins in Children with Familial Hypercholesterolemia | NEJM
New England Journal of Medicine 3d 7 tweets
Original Article from The New England Journal of Medicine — 20-Year Follow-up of Statins in Children with Familial Hypercholesterolemia
Eric Topol And a 20-year study to show how vital it is to make the diagnosis and treat familial hypercholesterolemia early in life 49h
The More Active Your Brain, the Shorter Your Lifespan May Be
Time 3d 2 tweets
According to a new study
Eric Topol I guess I better not buy any long-playing records 😉 (a slight over-interpretation of the worm and findings) 3d
Lipid Management for the Prevention of Atherosclerotic Cardiovascular Disease | NEJM
New England Journal of Medicine 3d 4 tweets
Review Article from The New England Journal of Medicine — Lipid Management for the Prevention of Atherosclerotic Cardiovascular Disease
Eric Topol The tour de force, up-to-date review of lipid management for prevention of atherosclerotic CV disease by and 3d
Unplugging the Pipeline — A Call for Term Limits in Academic Medicine | NEJM
New England Journal of Medicine 3d 7 tweets
Perspective from The New England Journal of Medicine — Unplugging the Pipeline — A Call for Term Limits in Academic Medicine
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Eric Topol And there's this remarkable graph of US medical school deans and department chairs today. by Whitney Beeler and 2070 to parity? 3d
Using Tech to Bring Humanity Back to Medicine | Aspen Ideas
Aspen Ideas Festival 3d 1 tweets
In modern-day medicine, doctors have little time to spend with patients. Author and cardiologist Eric Topol believes artificial intelligence can help.
Moderation of neural excitation promotes longevity
Nature.com 3d 3 tweets
Reducing neuronal excitation increases lifespan across species.
Eric Topol A relationship between the REST #brain gene in humans, decreased neuronal activity, and #longevity (supported by expt'l model) explainer by by Bruce Yankner and colleagues 3d
Regulation of lifespan by neural excitation and REST
Nature 3d 8 tweets
Studies of humans, mice and nematodes reveal a conserved role of neural activity and the transcription factor REST in extended longevity.
Eric Topol A relationship between the REST #brain gene in humans, decreased neuronal activity, and #longevity (supported by expt'l model) explainer by by Bruce Yankner and colleagues 3d