Eric Topol
physician-scientist, author, editor. My new book #DeepMedicine was just released
Last synced from Twitter 1m ago
The ROC Curve Redefined — Optimizing Sensitivity (and Specificity) to the Lived Reality of Cancer | NEJM
New England Journal of Medicine 10h 3 tweets
Perspective from The New England Journal of Medicine — The ROC Curve Redefined — Optimizing Sensitivity (and Specificity) to the Lived Reality of Cancer
Eric Topol Prof Sue Walker's ROC Curve: "We are as frail and vulnerable as everyone else. We are not too busy or too important to get sick. We are mortal....We all have a y axis and an x axis even if they don’t glow with the neon lights of #cancer" not to miss 10h
Scientists Create Speech From Brain Signals
Nytimes.com 13h 15 tweets
A prosthetic voice decodes what the brain intends to say and generates (mostly) understandable speech, no muscle movement needed.
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Eric Topol You can listen to people's brains speak and here by #openaccess 12h
Brain signals translated into speech using artificial intelligence
Nature.com 14h 4 tweets
Technology could one day be used to provide a voice for people who can’t talk.
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Eric Topol You can listen to people's brains speak and here by #openaccess 12h
Diagnosis of genetic diseases in seriously ill children by rapid whole-genome sequencing and automated phenotyping and interpretation
Science Translational Medicine 14h 4 tweets
When treating seriously ill children, time is of the essence. Clark et al . built an automated pipeline to analyze EHR data and genome sequencing data from dried blood spots to deliver a potential diagnosis for hospitalized, often critically ill,...
Eric Topol Rapid whole genome sequencing w/ #AI #NLP to make the diagnosis and save lives of very sick newborns by and collaborators 14h
Brain implants that let you speak your mind
Nature.com 15h 2 tweets
A brain–computer interface synthesizes speech using neural signals.
Eric Topol Here's the accompanying , a terrific explainer of this neuroscience + #AI feat #openaccess by and of the paper (Nov '18) 15h
Intelligible speech synthesis from neural decoding of spoken sentences
bioRxiv 15h 3 tweets
The ability to read out, or decode, mental content from brain activity has significant practical and scientific implications[1][1]. For example, technology that translates cortical activity into speech would be transformative for people unable to...
Eric Topol Here's the accompanying , a terrific explainer of this neuroscience + #AI feat #openaccess by and of the paper (Nov '18) 15h
Speech synthesis from neural decoding of spoken sentences
Nature 15h 12 tweets
A neural decoder uses kinematic and sound representations encoded in human cortical activity to synthesize audible sentences, which are readily identified and transcribed by listeners.
Eric Topol From #brain --> speech. Remarkable use of #Ai recurrent neural nets to transform brain activity to intelligible speech by 's Edward Chung major implications for patients with paralysis 15h
Over 2,000 Death Records Reveal the Cost of Skipping Breakfast
Inverse 16h 1 tweets
"What is clear is that a pattern of skipping breakfast identifies a population at risk."
Eric Topol You see what happens :-( 16h
Central Amygdala Prepronociceptin-Expressing Neurons Mediate Palatable Food Consumption and Reward
Neuron 17h 5 tweets
Eating calorically dense, palatable foods is a major contributor to obesity and binge eating. In this article, Hardaway et al. identify a central amygdala brain circuit expressing the neuropeptide prepronociceptin in mice that promotes palatable...
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Eric Topol "Neuronal noshing"—my amygdala made me do it! ;-) A hedonic, over-eating circuit in the #brain identified by and colleagues 17h
A machine learning device, meant for chronically ill, moves into homes
Casey Ross - STAT 20h 3 tweets
The device, called Current, is already used in hospitals, but FDA clearance means it can monitor patients at home, in between visits with their doctors.
Eric Topol The 1st remote monitoring device w/ #AI [], to get approval for home use, tracks all vital signs except blood pressure, The beginning of less need for hospital beds. by #DeepMedicine 17h
Remote Patient Monitoring & Telehealth Platform by Current Health
Current Health 17h 1 tweets
Current helps healthcare professionals keep patients healthy through continuous, wireless monitoring and precise early warning alerts.
Eric Topol The 1st remote monitoring device w/ #AI [], to get approval for home use, tracks all vital signs except blood pressure, The beginning of less need for hospital beds. by #DeepMedicine 17h
A medical app uses your smartphone’s camera to carry out lab tests at home
MIT Technology Review 19h 2 tweets
If you don't like going to the doctors urine luck. (sorry)
Eric Topol Beyond diagnosis of urinary tract infection use for ’s smartphone lab testing 19h
Symbiotic cardiac pacemaker
Nature Communications 34h 1 tweets
Implantable medical electronic devices are limited by battery lifetime and inflexibility, but self-powered devices can harvest biomechanical energy. Here the authors demonstrate cardiac pacing and correction of sinus arrhythmia with a symbiotic...
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Eric Topol When the energy for a pacemaker is the heart itself #openaccess nice step to actualize this alluring potential 34h
Genetic study homes in on height’s heritability mystery
Nature.com 37h 10 tweets
Analysis of 20,000 genomes reveals that rare gene variants can help to explain how the trait is inherited.
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Eric Topol At the Lost and Found for Height Heritability How adding rare variants from whole genome sequencing plus common GWAS variants --> a lot more explainability, by w/ 37h
Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction
Immunity 38h 1 tweets
Regulatory T (Treg) cells are important for preventing autoimmunity and maintaining tissue homeostasis. Schmidleithner et al. report a hydroxyprostaglandin dehydrogenase (HPGD)-mediated tissue- and context-dependent suppressor mechanism used by Treg...
Eric Topol Abdominal/visceral fat is a pro-inflammatory reservoir, increasing the risk of heart disease and #diabetes. Now we're learning about the role of regulatory T cells (Tregs) specifically targeting fat tissue: #T2D by 38h
Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study
Nature Medicine 3d 10 tweets
A prospective clinical study of cancer patients (I-PREDICT) demonstrated the feasibility of matching genomic alterations found in tumors to combined drug treatments.
Eric Topol When the graphic in the newspaper conveys the data better than in the paper nice work by on genomic mutation guided #cancer therapy #invidmed by 40h
Cancers controlled better when hit with multiple genetic drugs, UCSD study finds
Bradley J. Fikes - San Diego Union-Tribune 40h 1 tweets
Hitting cancers with many genetically targeted drugs at once improves tumor control and patient longevity
Eric Topol When the graphic in the newspaper conveys the data better than in the paper nice work by on genomic mutation guided #cancer therapy #invidmed by 40h
DNA methylation analysis and editing in single mammalian oocytes
PNAS 40h 1 tweets
Many mammalian nongenetic diseases and developmental disorders originate from oocyte DNA methylation abnormalities. However, prevention and correction of this maternally transmitted nongenetic disorder remains challenging because of the lack of...
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Eric Topol —OK, so you think #CRISPR-ing DNA is big? —Well, we can do methylation editing of single egg cells and change coat color or prevent an #epigenetic disorder Soochow University, 40h
Adaptive Evolution within Gut Microbiomes of Healthy People
Cell Host & Microbe 41h 2 tweets
Bacteria acquire adaptive mutations during infections, but the role of mutations in the gut microbiome is unknown. Zhao and Lieberman et al. report that Bacteroides fragilis adapts via mutation within healthy people. They discover genes important to...
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Eric Topol How the gut #microbiome evolves in healthy people using #metagenomics: B. fragilis de novo mutations; possible ancestry-specific findings S Zhao 41h
AI and the Rheumatologist: An Opportunity for Better Care
Healio.com 42h 1 tweets
Healio Rheumatology | My head is spinning as I start to write this editorial on the potential for artificial intelligence to profoundly change the practice of rheumatology and the way we care for our patients.I have just finished reading Deep...
Eric Topol Very appreciative of this review of #DeepMedicine by , a leading force for humanism in medicine (excerpted below) 42h