Eric Topol
physician-scientist, author, editor
Thought Leader
#143 Infectious Disease
Last synced from Twitter 81d ago
South Dakota reaches new highs in COVID-19 hospitalizations, daily cases
argusleader - Argus Leader 81d 2 tweets
Active cases also set record
Eric Topol What happens when you have such extremely high positive test rates? This. Via the sharp 👀 81d
The Remarkable Value of Thinking Broadly: A COVID-19 Trifecta
Medscape 81d 1 tweets
Social scientist and technology expert Zeynep Tufekci has been prescient about COVID-19 transmission. Eric Topol talks with her about how she does it and why such approaches make the difference.
1
Eric Topol One of the most interesting persons I've ever met——and an enthralling conversation about clairvoyance throughout the pandemic and beyond w/ transcript Masks. Aerosol transmission. Superspreaders. And so much more. 81d
Multi-omics resolves a sharp disease-state shift between mild and moderate COVID-19
Cell 81d 3 tweets
Using serial blood draws from hospitalized COVID-19 patients, Su et al. present an extensive single-cell multi-omics dataset covering the first week infection following clinical diagnosis, which includes information on plasma proteins, metabolites,...
Eric Topol What happens when #COVID19 progresses from mild to moderate illness? A unique single-cell multi-omics study of 139 patients (and controls): big immunologic shift, drop in blood nutrients today and colleagues 81d
Western States Join California’s Scientific Safety Review Workgroup to Ensure Safety of COVID-19 Vaccine | California Governor
California Governor 82d 3 tweets
Experts will independently review the safety and efficacy of COVID-19 vaccine SACRAMENTO – Washington, Oregon and Nevada have joined California’s COVID-19 Scientific Safety Review Workgroup…
1
Eric Topol My conversation w/ on vaccines this week Among the many important topics we discussed was trust. The disconcerting fact that many states have set up their own review process, which is unprecedented 81d
Pfizer C.E.O. All but Rules Out Vaccine Before Election Day
Katie Thomas - Nytimes.com 81d 2 tweets
Pfizer’s C.E.O. said on Tuesday that much-anticipated results from its vaccine trial would not be coming this month, after all.
1
Eric Topol Good news is that a vaccine will not be used as an election surprise (which would have meant unacceptable shortcuts) by by 81d
Pfizer Says Covid-19 Vaccine Late-Stage Trial Almost Fully Enrolled
Jared S. Hopkins - WSJ 81d 1 tweets
The Covid-19 pandemic weighed down sales for some Pfizer drugs in the latest quarter, while the company continues to work on its candidate vaccine for the virus.
1
Eric Topol Good news is that a vaccine will not be used as an election surprise (which would have meant unacceptable shortcuts) by by 81d
Hospitals Are Reeling Under a 46 Percent Spike in Covid-19 Patients
Simon Romero - Nytimes.com 81d 12 tweets
The number of people hospitalized with the coronavirus has climbed significantly from a month ago, straining cities that have fewer resources to weather the surges.
Eric Topol Covid, covid, covid, covid. This -> this And (3) is just getting warmed up, already highest in 10 weeks 81d
Why You Shouldn’t Worry About Studies Showing Waning Coronavirus Antibodies
Nytimes.com 82d 10 tweets
Experts say it’s normal for levels of antibodies to drop after clearing an infection, and that they represent just one arm of the immune response against a virus.
1
Eric Topol Or you can read this 1st rate piece by today w/ and 82d
COVID-19 associated arterial ischaemic stroke and multisystem inflammatory syndrome in children: a case report
The Lancet Child & Adolescent Health 82d 1 tweets
A 9-year-old girl was admitted to the paediatric intensive care unit (PICU) with a history of high-grade fever for 14 days, throbbing frontal headache, vomiting, and progressive weakness on the right side of her body for 5 days. Severe acute...
3
Eric Topol A 9-year-old girl who presented with stroke, first case report of #COVID19 multisystem inflammatory syndrome in children (MIS-C) with such a presentation 82d
What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2
The Lancet Infectious Diseases 82d 4 tweets
The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused more than 1 million deaths in the first 6 months of the pandemic and huge economic and social upheaval internationally. An efficacious vaccine is...
2
Eric Topol Does it work? The efficacy of #SARSCoV2 vaccines is front and center, making the timing of this new review ideal 82d
Eric Topol Very good timeline graphic for virus exposure, symptom onset, testing from and colleagues 81d
I'm the FDA point person on COVID-19 vaccines. We'll make sure they're safe and effective.
USA TODAY 82d 7 tweets
We pledge to do our duty to the best of our ability, independently and without conflicts of interest, and we will be transparent about FDA decisions.
Eric Topol At FDA, Peter Marks, who heads CBER and the vaccine review. His essay provides strong reinforcement for this trust via /3 82d
For COVID-19 Vaccines, ACIP Will Be a Critical Gatekeeper
Medscape 82d 2 tweets
Eric Topol and vaccine expert Paul Offit have a one-on-one to discuss where we are regarding the development, authorization, and/or licensure of vaccines to prevent COVID-19.
1
Eric Topol My conversation w/ on vaccines this week Among the many important topics we discussed was trust. The disconcerting fact that many states have set up their own review process, which is unprecedented 81d
Eric Topol An up-to-the-moment vaccine perspective by : we spoke yesterday after the Advisory Committee On EUAs, ethical dilemma: crossover of placebo->active, superhuman immune response, need for masks (no magic), transparency, and the FDA. w/transcript 82d
Two Studies Show COVID-19 Antibodies Persist for Months
NIH Director's Blog 89d 2 tweets
More than 8 million people in the U.S. have now tested positive for COVID-19. For those who have recovered, many wonder whether having already fended off SARS-CoV-2, the coronavirus that causes COV…
5
Eric Topol I wish all these déjà vu reports of "disappearing antibodies" would disappear. That is not a problem. by 82d
Some Covid Survivors Have Antibodies That Attack the Body, not Virus
Nytimes.com 82d 24 tweets
New research found ‘autoantibodies’ similar to those in lupus and rheumatoid arthritis patients. But patients may also benefit from treatments for those autoimmune diseases.
3
Eric Topol We're starting to learn about auto-antibodies, autoimmune marker sequelae in a small cohort w/ severe #COVID19. Still much unknown ?s :#LongCovid, mild infections, antigen, role of virus reservoir or remnants w/ 82d
β-Coronaviruses use lysosomes for egress instead of the biosynthetic secretory pathway
Cell 82d 4 tweets
Altan-Bonnet et al. provide evidence that β-Coronaviruses do not use the biosynthetic secretory pathway typically used by enveloped viruses to leave infected cells. Instead, these viruses traffic to lysosomes for unconventional egress by...
Eric Topol Add to the "then what? Eggression via lysosomes (β-coronaviruses, which is unconventional) 82d
Does Your State Have a Mask Mandate Due to Coronavirus?
AARP 82d 1 tweets
In August, Mississippi, Vermont and Wisconsin joined the list of states that require people to cover their faces in public. See where every state stands on face masks.

2
Eric Topol Of the top 6 US states by new confirmed infections, how many have a mask mandate? None. Montana has a partial one 82d
Comparative ACE2 variation and primate COVID-19 risk
Communications Biology 82d 2 tweets
Amanda Melin et al. compare variation in 29 primate species at 12 amino acid residue sites coded by the ACE2 gene and show that apes and African and Asian monkeys exhibit the same set of twelve key amino acid residues as human ACE2. These results...
Eric Topol "We also have a duty to ensure that our closest living relatives do not suffer from devastating infections and further population declines in response to yet another human-induced catastrophe." 82d
Covid-19 expert Akiko Iwasaki fights a different virus: sexism in science
Shraddha Chakradhar - STAT 82d 30 tweets
To know virologist Akiko Iwasaki is to know that she is passionate about combatting sexism, power imbalance, and toxic behavior in academia.
Eric Topol Correct link and our recent interview 82d
‘Every minute counts.’ This immunologist rapidly reshaped her lab to tackle COVID-19
Science | AAAS 82d 12 tweets
For Akiko Iwasaki, the pandemic has brought new research priorities—and new urgency
5
Eric Topol So great to see my friend and her team's pandemic leading work getting this richly deserved recognition by by 82d
5
Eric Topol So great to see my friend and her team's pandemic leading work getting this richly deserved recognition by by 82d
Aerosol persistence in relation to possible transmission of SARS-CoV-2
AIP Publishing 82d 1 tweets
Transmission of SARS-CoV-2 leading to COVID-19 occurs through exhaled respiratory droplets from infected humans. Currently, however, there is much controversy over whether respiratory aerosol micro...
1
Eric Topol New "Aerosol transmission [ #SARSCoV2] is possible but perhaps not a very efficient route, in particular from non-symptomatic or mildly symptomatic individuals that exhibit low viral loads." 82d