Eric Topol
physician-scientist, author, editor
Last synced from Twitter 10d ago
Livebirth after uterus transplantation from a deceased donor in a recipient with uterine infertility
The Lancet 10d 2 tweets
We describe, to our knowledge, the first case worldwide of livebirth following uterine transplantation from a deceased donor in a patient with MRKH syndrome. The results establish proof-of-concept for treating uterine infertility by transplantation...
Eric Topol Last week it was the 1st #CRISPRbabies This week, it's 1st birth after a uterus transplant via a deceased donor (done properly) 10d
Non–US-Born and Noncitizen Health Care Professionals in the United States, 2016
Jamanetwork.com 10d 2 tweets
This national survey study uses US Census Bureau data to estimate the proportion of non–US-born and noncitizen health care professionals in the United States in 2016.
2
Eric Topol The immigrant clinician workforce in the United States a striking 17% #healthcare professionals born outside the US. Where would we be without them? by and colleagues 10d
The Future of the Medical Profession
Jamanetwork.com 10d 1 tweets
Scarcely have we had time to realize that the great war is over when the numerous after-the-war problems present themselves. Reconstruction seems to be the word
1
Eric Topol 100 years later, and many common threads 10d
Before Starting A Statin, Talk It Over With Your Doctor
NPR.org 11d 4 tweets
Patients and doctors should have nuanced conversations about the benefits and risks of statins before deciding to start them. The drugs can reduce heart attack odds but also carry some side effects.
Eric Topol The methodology and calculus directly challenges the guidelines and recommendations and the US Preventive Services Task Force #USPSTF Here are patient instructions and coverage by 10d
Smartphone app for non-invasive detection of anemia using only patient-sourced photos
Nature Communications 10d 2 tweets
Anemia has a global prevalence of over 2 billion people and is diagnosed via blood-based laboratory test. Here the authors describe a smartphone app that can estimate hemoglobin levels and detect anemia by analyzing pictures of fingernail beds taken...
1
Eric Topol Anemia detection via your smartphone, anywhere, anytime by and colleagues 10d
In Grandma’s Stocking: An Apple Watch To Monitor Falls, Track Heart Rhythms
Kaiser Health News 11d 2 tweets
The new-generation gadget is designed to alert and protect wearers from falls and heart problems, expanding Apple’s target audience beyond the usual, tech-savvy, early adopters to those with older …
Eric Topol What happens when a sensor is applied indiscriminately? by We'll be finding out ..... 11d
Clinical epigenetics: seizing opportunities for translation
Nature Reviews Genetics 18d 2 tweets
Disruptions to the epigenome occur during the pathogenesis of various human diseases. In this Review, Berdasco and Esteller describe the challenges and progress of harnessing epigenetic changes for clinical application, including for diagnostics,...
Eric Topol A title you might not have envisioned: "Clinical #Epigenetics" a super review by 11d
The Hands of an Angel | Annals of Internal Medicine | American College of Physicians
Annals.org 11d 1 tweets
We huddled together on opposite sides of the nurses' station like sweaty preadolescents at their first middle school dance: interns on one side, newly graduated nurses on the other. Mrs. Lincoln, the veteran head nurse of 3 West, stood before us,...
1
Eric Topol The Hands of an Angel: a tragedy and medical love story by Richard Weinberg 11d
Visualization of asymptomatic atherosclerotic disease for optimum cardiovascular prevention (VIPVIZA): a pragmatic, open-label, randomised controlled trial
The Lancet 11d 1 tweets
This study provides evidence of the contributory role of pictorial presentation of silent atherosclerosis for prevention of cardiovascular disease. It supports further development of methods to reduce the major problem of low adherence to...
10
Eric Topol When a person sees a picture of their atherosclerosis (of carotid artery), it promotes prevention w/ risk factor modification, including lifestyle. Results of a randomized trial 11d
Weighing the Harms and Benefits of Using Statins for Primary Prevention | Annals of Internal Medicine | American College of Physicians
Annals.org 11d 1 tweets
In this issue, Yebyo and colleagues challenge the risk thresholds in current guidelines for use of statins for primary prevention of cardiovascular disease. The editorialists discuss how the findings can support patient-centered decision making,...
Eric Topol This calculation was: "much more elaborate, incorporating age- and sex- expected benefit and risk for adverse effects" from the accompanying editorial by 11d
Ensuring Fairness in Machine Learning to Advance Health Equity | Annals of Internal Medicine | American College of Physicians
Annals.org 11d 4 tweets
Machine learning is used increasingly in clinical care to improve diagnosis, treatment selection, and health system efficiency. Because machine-learning models learn from historically collected data, populations that have experienced human and...
Eric Topol What can be done to preempt #AI making health inequities worse, but instead ensuring fairness? Or even reducing inequities? by editorial @5harad 11d
Machine Learning, Health Disparities, and Causal Reasoning | Annals of Internal Medicine | American College of Physicians
Annals.org 11d 2 tweets
Rajkomar and colleagues warn us that the introduction of machine-learned predictive algorithms into medicine might inadvertently reinforce or create inequitable treatment of protected groups, for which the computer science community has adopted the...
Eric Topol What can be done to preempt #AI making health inequities worse, but instead ensuring fairness? Or even reducing inequities? by editorial @5harad 11d
Balance of Benefits and Harms When Using Statins for Prevention of CVD | Annals of Internal Medicine | American College of Physicians
Annals.org 11d 4 tweets
Background: Many guidelines use expected risk for cardiovascular disease (CVD) during the next 10 years as a basis for recommendations on use of statins for primary prevention of CVD. However, how harms were considered and weighed against benefits...
4
Eric Topol The problem for statins for primary prevention of heart disease: they are significantly over-prescribed by et al 11d
The CRISPR Baby Scandal Gets Worse by the Day
Ed Yong - The Atlantic 11d 39 tweets
The alleged creation of the world's first gene-edited infants was full of technical errors and ethical blunders. Here are the 15 most damning details.
Nanoscale tweezers for single-cell biopsies
Nature Nanotechnology 11d 2 tweets
A nanotweezer system based on dielectrophoresis can trap, manipulate and extract biomolecules and organelles in living cells at physiological conditions with high spatiotemporal resolution and minimal invasiveness.
Eric Topol So you want to extract an organelle from a single cell? or DNA from a nucleus? These nano-tweezers will come in handy ;-) 11d
Lnc-ing microRNA activity to atheroprotection
Nature Metabolism 12d 1 tweets
Cholesterol accumulation in cells and blood vessels promotes the development of vascular diseases. The long non-coding RNA CHROME can help clear excess cholesterol and provide protection from atherosclerosis.
Eric Topol Discovery of an important non-coding RNA key in atherosclerosis and cholesterol clearance (so much still hidden in our lncRNAs) 12d
The long noncoding RNA CHROME regulates cholesterol homeostasis in primates
Nature Metabolism 12d 1 tweets
Maintenance of cholesterol homeostasis is essential to human health. Here, the authors identify and characterize a primate-specific long noncoding RNA, called CHROME, that controls cholesterol homeostasis through fine-tuning of miRNAs and whose...
Eric Topol Discovery of an important non-coding RNA key in atherosclerosis and cholesterol clearance (so much still hidden in our lncRNAs) 12d
Discovery of common and rare genetic risk variants for colorectal cancer
Nature Genetics 12d 2 tweets
Genome-wide association analyses based on whole-genome sequencing and imputation identify 40 new risk variants for colorectal cancer, including a strongly protective low-frequency variant at CHD1 and loci implicating signaling and immune function in...
2
Eric Topol A polygenic risk score for colon #cancer, useful for screening, based upon > 125,000 people, now w/ 100 risk & protective loci, along w/ new insights about the disease by and collaborators 12d
AlphaFold: Using AI for scientific discovery
DeepMind 12d 20 tweets
Our system, AlphaFold, which we have been working on for the past two years, builds on years of prior research in using vast genomic data to predict protein structure. The 3D models of proteins that AlphaFold generates are far more accurate than any...
Eric Topol Using deep learning #AI to accurately predict #3D protein structure From #AlphaGo-> #AlphaFold by and colleagues 12d
Google's DeepMind predicts 3D shapes of proteins
Ian Sample - the Guardian 12d 19 tweets
AI program’s understanding of proteins could usher in new era of medical progress
Eric Topol Using deep learning #AI to accurately predict #3D protein structure From #AlphaGo-> #AlphaFold by and colleagues 12d