Eric Topol
physician-scientist, author, editor
Last synced from Twitter 12m ago
Corroboration of a Major Role for Herpes Simplex Virus Type 1 in Alzheimer’s Disease
Frontiers 18h 1 tweets
Strong evidence has emerged recently for the concept that herpes simplex virus type 1 (HSV1) is a major risk for Alzheimer's disease (AD). This concept proposes that latent HSV1 in brain of carriers of the type 4 allele of the apolipoprotein E gene...
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Eric Topol Herpes virus may "account" for half of #Alzheimers patients??? by Ruth Itzhaki 18h
Herpes may account for 50 percent of Alzheimer's cases
Medical News Today 18h 1 tweets
A large review suggests that the herpes virus may result in a heightened risk of senile dementia, and may account for numerous Alzheimer's diagnoses.
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Eric Topol Herpes virus may "account" for half of #Alzheimers patients??? by Ruth Itzhaki 18h
We can now customize cancer cures, tumor by tumor
Adam Piore - MIT Technology Review 3d 4 tweets
But can any company afford to manufacture one-off medical treatments?
Eric Topol The #cancer cure chasm Glad to see this title was fixed cures are all too rare and ≠ treatment 19h
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
Science 44h 6 tweets
CRISPR-Cas systems provide microbes with adaptive immunity to infectious nucleic acids and are widely employed as genome editing tools. These tools utilize RNA-guided Cas proteins whose large size (950–1400 amino acids) has been considered essential...
Eric Topol If you got Class 1 down, here's Type V ;-) from this week's 19h
A new device can identify air travellers carrying an infectious disease
The Economist 27h 3 tweets
Stopping illnesses spreading through airports
Eric Topol The next bottleneck? 22h
Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016–40 for 195 countries and territories
The Lancet 4d 26 tweets
With the present study, we provide a robust, flexible forecasting platform from which reference forecasts and alternative health scenarios can be explored in relation to a wide range of independent drivers of health. Our reference forecast points to...
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Eric Topol An opus #GBD forecast of health and life expectancy around the world to 2040, w/ major drivers of high blood pressure, obesity and #T2D #diabetes #OA by 23h
Crowdfunding Model for Conducting Clinical Studies
Jamanetwork.com 24h 1 tweets
This Viewpoint describes a process of conducting medical research that uses online crowdfunding as a model for recruiting and reviewing investigators and data.
Eric Topol Beyond crowdfunding medical research, there's the idea of crowd-investigators 24h
Use of Trend Statements to Describe Statistically Nonsignificant Results in the Oncology Literature
Jamanetwork.com 41h 2 tweets
This study examines recent original research articles in leading oncology journals to evaluate the use of statements about the trend of a P value toward significance to describe statistically nonsignificant results.
Eric Topol The use of "trend" statements for not statistically significant results, but aligned with author's assertions, is still prevalent but has got to go by 24h
Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk
Cell 42h 4 tweets
In a large multi-cohort study, unexplained heritability for multiple sclerosis is detected in low-frequency coding variants that are missed by GWAS analyses, further underscoring the role of immune genes in MS pathology.
Eric Topol Expanding the genomic underpinnings of multiple sclerosis via sequencing, discovery of rare and low frequency variants #MS 24h
Scientists argue heart stem cell trial should be paused
carolyn johnson - Washington Post 35h 5 tweets
The taxpayer-funded trial used stem cells that were once thought to regenerate heart muscle.
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Eric Topol An ongoing heart stem cell clinical trial, based in part by fabricated data, should be stopped. by 35h
Project Baseline Aims to Ward Off Illness Before We Get Sick
Nytimes.com 40h 8 tweets
Researchers are recruiting 10,000 volunteers to discover the earliest warning signs of cancer, heart disease and other killers.
Eric Topol Will Project Baseline help prevent diseases? The up and down-sides of deep phenotyping by 40h
Somatic mutant clones colonize the human esophagus with age
Science 44h 5 tweets
The extent to which cells in normal tissues accumulate mutations throughout life is poorly understood. Some mutant cells expand into clones that can be detected by genome sequencing. We mapped mutant clones in normal esophageal epithelium from nine...
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Eric Topol An important #cancer paper on how we've got a big burden of somatic mutations but v small transition -> malignancy et al Well covered by master explainer as the "cancer paradox" 44h
Researchers Explore a Cancer Paradox
Nytimes.com 45h 13 tweets
Healthy cells carry a surprising number of cancer-linked mutations, but they don’t turn into tumors. What’s holding them back?
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Eric Topol An important #cancer paper on how we've got a big burden of somatic mutations but v small transition -> malignancy et al Well covered by master explainer as the "cancer paradox" 44h
Well-being in metrics and policy
Science 44h 4 tweets
This century is full of progress paradoxes, with unprecedented economic development and improvements in longevity, health, and literacy coexisting with climate change, persistent poverty in the poorest countries, and increasing income inequality and...
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Eric Topol The metrics of well-being: what drives this and what should we to about it? by intriguing essay, important to promoting health 44h
Realizing private and practical pharmacological collaboration
Science 45h 2 tweets
Increased collaboration will enhance our ability to predict new therapeutic drug candidates. Such data sharing is currently limited by concerns about intellectual property and competing commercial interests. Hie et al. introduce an end-to-end...
Eric Topol Catalyzing discovery of drug interactions by "secret sharing" and neural networks, coalescing proprietary sources to rev up biomedical research by 's Hie, , Berger #AI #Crypto #openscience 45h
Deep echocardiography: data-efficient supervised and semi-supervised deep learning towards automated diagnosis of cardiac disease
npj Digital Medicine 46h 1 tweets
Deep echocardiography: data-efficient supervised and semi-supervised deep learning towards automated diagnosis of cardiac disease
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Eric Topol Deep learning echocardiography: using GANs to learn from unlabeled data, improving efficiency #AI Digital Medicine #OA by 46h
Human Cortical Dendrites: Stretched to Perform Better?
Cell 47h 1 tweets
Most functional properties of human dendrites have been inferred from data obtained in model organisms. In this issue, Beaulieu-Laroche et al. record directly from human dendrites of cortical neurons and show that the considerably larger human...
Eric Topol What makes human neurons unique? stretttttttch perspective Dalugge and Remy by 's Mark Harnett and colleagues 47h
Enhanced Dendritic Compartmentalization in Human Cortical Neurons
Cell 47h 4 tweets
Human cortical neurons exhibit a higher degree of voltage compartmentalization compared to rodent counterparts due to lower ion channel densities across larger dendritic surfaces.
Eric Topol What makes human neurons unique? stretttttttch perspective Dalugge and Remy by 's Mark Harnett and colleagues 47h
Carbotoxicity—Noxious Effects of Carbohydrates
Cell 48h 4 tweets
The effects of excessive intake of carbohydrates in diets worldwide is discussed at a mechanistic and functional perspective.
Eric Topol The toxicity of carbohydrates —"Carbotoxicity'—adverse impact on human health: molecular, cellular, hormonal basis cc 48h
Neurocognitive and Hormonal Correlates of Voluntary Weight Loss in Humans
Cell Metabolism 48h 2 tweets
Dagher et al. tested the hypothesis that hormonal adaptations during dieting override eating self-control in 24 overweight participants on a 1,200 kcal/day diet. They found that brain activity in cognitive control regions, rather than hormones...
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Eric Topol Achieving weight loss tied to #brain's loci of self-control and colleagues 48h