Objective To derive and validate a risk prediction algorithm to estimate hospital admission and mortality outcomes from coronavirus disease 2019 (covid-19) in adults.
Design Population based cohort study.
Setting and participants QResearch...
Shares of AstraZeneca, a front-runner in the Covid-19 vaccine race, gave up a slight gain after the news broke.
Eric TopolOn the death of a participant in the Astra-Zeneca vaccine trial, the lack of concern of safety by @UniofOxford points to either a placebo assignment or altogether unrelated to the vaccine
(US trial is still on hold, 6 weeks after the adverse event notice)
Ferretti et al. reveal specific SARS-CoV-2 epitopes that are broadly shared by CD8+
T cells of COVID-19 patients but exhibit limited cross-reactivity with seasonal coronaviruses.
Most epitopes are located outside the spike protein, suggesting that...
Eric TopolThe CD8+ T cells after covid-19:
—90% don't recognize the Spike protein, they share epitopes mostly in ORF1 and nucleocapsid
—Lack (near zero) cross-reactivity with the common cold coronaviruses
cell.com/immunity/fullt… New @ImmunityCP unbiased screens in 19 patients
All the weak points of American health care — testing delays, communication breakdowns, inequity — are working against this potential treatment.
Eric TopolThe #SARSCoV2 monoclonal antibody (mAb) rollout is going to be very complicated.
nytimes.com/2020/10/20/hea…@katie_thomas covers many issues here, including potential need for rapid antibody testing. Add this one:
These are outpatient infusions. Where is the mAb infusion clinic?
For most people, COVID-19 test entails a swab up the nose in a doctor’s office or at a drive-in site. The sample then goes out to a lab. Results come back within a few days to a week—a waiting period that’s simply too long to stop the spread of the...
Governments are flexing enforcement muscles more forcefully than any time since March in response to a resurgence of the coronavirus. Fines for public-health violations are rising in most countries and so are punishments for breaking curfews, local...