Eric Topol
physician-scientist, author, editor. My new book is #DeepMedicine
Last synced from Twitter 11m ago
Alcohol and Cancer Risk—Clinical and Research Implications
Jamanetwork.com 14h 5 tweets
This Viewpoint reviews the epidemiologic evidence documenting the association between alcohol consumption and cancer risk, and calls for possible health responses and research into interventions for decreasing overall alcohol consumption as a means...
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Eric Topol A stern warning about the risk of #cancer associated with alcohol by 's w/ the curious trade-off of less heart attacks 1/x But 👇 13h
AIs direct search for materials breakthroughs
Science 19h 2 tweets
In July 2018, Curtis Berlinguette, a materials scientist at the University of British Columbia in Vancouver, Canada, realized he was wasting his graduate student's time and talent. He had asked her to refine a key material in solar cells to boost...
Eric Topol Lessons from #AI for material science (which was behind other areas, now revved up) very applicable to life science, especially drug discovery by w/ for quick read: the 2 callouts tell the story 15h
Rude paper reviews are pervasive and sometimes harmful, study finds
Science | AAAS 36h 15 tweets
Researchers of color particularly vulnerable to “unprofessional” comments
Eric Topol Would be interesting to see the relationship between rude reviewers of science papers and nasty folks on by on paper by & 16h
Why are people attracted to 50:50 probabilities?
The Economist 16h 1 tweets
A working paper suggests that ambiguous odds are often interpreted as even
Eric Topol Why are we attracted so much to 50:50 probabilities? by Thomas Graeber It's our "cognitive uncertainty" w/ lack of confidence and a "mental default" of = probabilities 16h
Cognitive Uncertainty
NBER 6d 2 tweets
Eric Topol Why are we attracted so much to 50:50 probabilities? by Thomas Graeber It's our "cognitive uncertainty" w/ lack of confidence and a "mental default" of = probabilities 16h
The Ig Nobel Prize Winners
Improbable Research 16h 1 tweets
For achievements that first make people LAUGH then make them THINK Winners by year: 2019 : 2018 : 2017 : 2016 2015 : 2014 : 2013 : 2012 : 2011 2010 : 2009 : 2008 : 2007 : 2006 2005 : 2004 : 2003 : …
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Eric Topol On mega-authorships: In 1993, we (The GUSTO Investigators) received the IgNobel prize for having 972 authors (there was really only 1, the study group name) Now shows >1,000 authors is getting more common 16h
Hyperauthorship: global projects spark surge in thousand-author papers
Nature.com 17h 4 tweets
The mass-authorship trend that began in particle physics is spreading to other fields.
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Eric Topol On mega-authorships: In 1993, we (The GUSTO Investigators) received the IgNobel prize for having 972 authors (there was really only 1, the study group name) Now shows >1,000 authors is getting more common 16h
EATLancet vs yes2meat: the digital backlash to the planetary health diet
The Lancet 18d 9 tweets
Food production, climate change, and human health are intrinsically related. The EAT–Lancet Commission1 is one of the first attempts to summarise and communicate the best available science on what constitutes a healthy diet within environmental...
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Eric Topol "Scientists and journals face serious challenges in a rapidly changing media landscape that is susceptible to the intentional dissemination of misleading content." and colleagues on a healthy #diet for the planet analysis #openacess 18h
Reinventing the eye exam
The Lancet 35h 3 tweets
Ophthalmology has long been one the most innovative and technology-driven of the medical specialties—from the mid-19th century, when Hermann von Helmholtz and Charles Babbage competed to produce the first ophthalmoscope, to the 21st century, when...
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Eric Topol The broad perception in medical-#AI is that radiology is the discipline that is the pacesetter. But it may actually be ophthalmology 17h
Eric Topol The #AI Eye 👁️👁️ space is setting the pace for change in medicine, as summed up in the new Digital Medicine essay by and me 35h
Bloomberg - Are you a robot?
Bloomberg.com 37h 6 tweets
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Eric Topol 2 problems here: 1. These drugs are not miracles; the median extension of life is x months & they cost a fortune 2. The #cancer-fixation sucks out development & interest for other important diseases w/ unmet needs by 37h
Pervasive human-driven decline of life on Earth points to the need for transformative change
Science 38h 7 tweets
For decades, scientists have been raising calls for societal changes that will reduce our impacts on nature. Though much conservation has occurred, our natural environment continues to decline under the weight of our consumption. Humanity depends...
Eric Topol While most of us work on relatively little things, these folks are onto big ones, like the planet and its inhabitants by & colleagues, impressive review + congrats for richly deserved recognition 38h
Depletion of microbiome-derived molecules in the host using Clostridium genetics
Science 39h 1 tweets
The clostridia are Firmicute bacterial commensals commonly found in the mammalian gut. Clostridia produce a range of metabolites that diffuse into the host's circulation and have been difficult to manipulate genetically, but Guo et al. successfully...
Eric Topol Two approaches to deconstruct the ridiculously complex #microbiome 1. #CRISPR by et al 2. Computational, synthetic bio ★ Commentary: by 39h
As China puts on weight, type-2 diabetes is soaring
The Economist 40h 1 tweets
Trying harder to prevent and treat it could save both lives and money
Eric Topol We "winning" and China is catching up in a race going in the wrong direction #T2D #diabetes 40h
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
Cell 40h 3 tweets
Genome-wide analyses of eight different psychiatric disorders reveals common loci and shared genetic structures underlying many of them.
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Eric Topol So many common genomic threads across 8 neuropsychiatric conditions from this analysis of > 725,000 people by + a big collaborative network 40h
Toward a Common Coordinate Framework for the Human Body
Cell 42h 8 tweets
Satija, Regev, Marioni, and colleagues recommend approaches to create a reference map of the human body down to the single-cell level—a task made challenging by the diverse human form.
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Eric Topol Digitizing the human body with a common coordinate framework so we can construct maps at many levels at scale, by 42h
AI Index 2019
Stanford Institute for Human-Centered Artificial Intelligence 53h 6 tweets
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Eric Topol The 2019 #AI report, a 291-page #openaccess file, chock full of interesting data like this via 51h
Accepted articles Theranostics
Thno.org 55h 1 tweets
Eric Topol And #AI real-time OCT for colonoscopy diagnostics but the reported level of accuracy looks too good to be true 55h
10 Years Ago, DNA Tests Were The Future Of Medicine. Now They’re A Social Network — And A Data Privacy Mess.
Peter Aldhous - BuzzFeed News 3d 8 tweets
We were offered personalized medicine. Instead, we got Facebook for our DNA.
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Eric Topol Our DNA Future? Among many points in the piece, had (by and ) for his heart disease polygenic risk score and averted taking a statin "Patients don't usually show up wanting to talk about their DNA" 57h
Adjö — My Patient’s Prolonged Good-Bye | NEJM
New England Journal of Medicine 60h 2 tweets
Perspective from The New England Journal of Medicine — Adjö — My Patient’s Prolonged Good-Bye
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Eric Topol "In the race of life, he now runs alone." A beautiful, touching essay by … 60h
Machine Learning and the Cancer-Diagnosis Problem — No Gold Standard | NEJM
New England Journal of Medicine 3d 4 tweets
Perspective from The New England Journal of Medicine — Machine Learning and the Cancer-Diagnosis Problem — No Gold Standard
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Eric Topol "Machine-learning algorithms promise to deliver faster and more consistent diagnoses than humans and to ultimately improve patient care" but....in #cancer, #AI appreciation of gray zones, is important for #pathologists by and Gil Welch 3d