Eric Topol
physician-scientist, author, editor. My new book is #DeepMedicine
Last synced from Twitter 11m ago
The Need to Improve the Clinical Utility of Direct-to-Consumer Genetic Tests: Either Too Narrow or Too Broad
Jamanetwork.com 47h 2 tweets
This Viewpoint summarizes current shortcomings in direct-to-consumer genetic tests, which often lack clinical utility for consumers, and explains how tests that encompass entire genes and include only genes with well-established risk estimates and...
Eric Topol Goldilocks #genomics: consumer offerings are just too narrow or too broad, say and Angela Bradbury 33m
Powerful antibiotics discovered using AI
Nature.com 24h 6 tweets
Machine learning spots molecules that work even against ‘untreatable’ strains of bacteria.
Eric Topol "The study is remarkable, says Jacob Durrant ... The team didn’t just identify candidates, but also validated promising molecules in animal tests." by May be the best #AI-drug story yet, especially for unmet need. 47m
A Machine Learning Individualized Treatment Rule in First-Episode Schizophrenia
Jamanetwork.com 2h 1 tweets
This prognostic study describes the development and validation of an individualized treatment rule for patients with first-episode schizophrenia.
Eric Topol It may be the 1st, but it didn't work very well an #AI ML model to predict individualized treatment response for schizophrenia (1st episode) in a retrospective dataset 2h
How to Change Anyone’s Mind
WSJ 3h 3 tweets
People instinctively resist being forced to do things differently. Instead of pushing, try removing the barriers that stand in their way.
Eric Topol "Doctors deal with this issue when trying to get patients to change to healthier behavior." Every day. How to change anyone's mind. It's not easy. by 3h
How to save America with artificial intelligence
TheHill 3h 1 tweets
We must not hesitate to harness the Founding Fathers’ collective legacy for the betterment of the nation that they cherished so dearly.
Eric Topol Adding this to my list of pure, unadulterated #AI hype 3h
No raw data, no science: another possible source of the reproducibility crisis
Molecular Brain 17h 6 tweets
A reproducibility crisis is a situation where many scientific studies cannot be reproduced. Inappropriate practices of science, such as HARKing, p-hacking, and selective reporting of positive results, have been suggested as causes of...
Eric Topol No raw data, no science , the editor of Molecular Brain , relates his experience of authors (40/41) not supplying their raw data and why this is essential to foster reproducibility #openaccess 4h
Machine Learning for Antibiotics
In the Pipeline 27h 4 tweets
I know that I just spoke about new antibiotic discovery here the other day, but there's a new paper worth highlighting that just came out today. A team from MIT, the Broad Institute, Harvard, and McMaster reports what is one of the more interesting...
Eric Topol When there's any report about an #AI and drug discovery effort, my "go to" is for perspective. When he says "So overall, this is an impressive paper," it has gravitas 16h
Why Are Nonprofit Hospitals So Highly Profitable?
Nytimes.com 20h 10 tweets
These institutions receive tax exemptions for community benefits that often don’t really exist.
Eric Topol "Why are nonprofit hospitals so highly profitable?" asks Adding some data to her spot on essay here are 2 tables on (1) the most profitable not-for-profit #healthcare systems and (2) CEO and executive pay 18h
Offline: Facts are not enough
The Lancet 18h 6 tweets
We are in the midst of a struggle. A struggle for the soul of global health. On one side, the intelligent idealists. Those who sincerely believe that by describing the world in ever more refined and precise ways we will advance closer to an elusive...
Eric Topol A struggle for the soul of global health: intelligent idealists vs. innocent cynics..... "will define the trajectory for the survival of our species" by #infomedics 18h
A cell atlas of human thymic development defines T cell repertoire formation
Science 20h 4 tweets
The human thymus is the organ responsible for the maturation of many types of T cells, which are immune cells that protect us from infection. However, it is not well known how these cells develop with a full immune complement that contains the...
Eric Topol A beautiful demonstration (no less aesthetic) of the power of single-cell sequencing to unravel the development & repertoire of T cells Sarah Teichmann 20h
Stem cells and the heart—the road ahead
Science 23h 1 tweets
Heart disease is the primary cause of death worldwide, principally because the heart has minimal ability to regenerate muscle tissue. Myocardial infarction (heart attack) caused by coronary artery disease leads to heart muscle loss and replacement...
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Eric Topol 18 years after the first stem cell clinical trials for heart damage there is little to show for it. Can the next chapter using pluripotent stem cells make a difference? … by w/ 23h
Passenger Mutations in More Than 2,500 Cancer Genomes: Overall Molecular Functional Impact and Consequences
Cell 24h 1 tweets
Analysis of datasets from the ICGC/TCGA Pan-cancer Analysis of Whole Genomes project looks at what roles passenger mutations play in tumorigenesis.
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Eric Topol Passenger mutations in #cancer never get enough attention. But and colleagues zoomed in on >2500 of them and showed it's not a 0|1 story. They didn't use "back-seat driver" terminology but characterize many intermediates 24h
A deluge of data is giving rise to a new economy
The Economist 26h 2 tweets
Ludwig Siegele asks how it will work
Eric Topol The world #bigdata deluge, now ~ 50 zettabytes, will eventually exceed yottabytes. So we need to name octillion --30 0's--or what I call helluvabytes 😉 26h
A Deep Learning Approach to Antibiotic Discovery
Cell 26h 9 tweets
A trained deep neural network predicts antibiotic activity in molecules that are structurally different from known antibiotics, among which Halicin exhibits efficacy against broad-spectrum bacterial infections in mice.
Eric Topol We need new antibiotics to counter resistance. Now 's James Collins, , & team have trained a #deeplearning #AI model to help the path of discovery 26h
The EU wants to set the rules for the world of technology
The Economist 28h 1 tweets
On data protection, artificial intelligence, competition and more
Eric Topol Unlike the U.S., Europe is into protecting individuals for their data and the use of #AI, now going beyond #GDPR by 28h
Big Tech to Face More Requirements in Europe on Data Sharing, AI
Valentina Pop - WSJ 28h 2 tweets
American tech companies will soon need to meet new requirements in the European Union regarding artificial intelligence and sharing data with smaller rivals, as the bloc seeks to assert its “technological sovereignty” from the U.S. and China.
Eric Topol Unlike the U.S., Europe is into protecting individuals for their data and the use of #AI, now going beyond #GDPR by 28h
Behavioral Heuristics in Coronary-Artery Bypass Graft Surgery | NEJM
New England Journal of Medicine 28h 1 tweets
Correspondence from The New England Journal of Medicine — Behavioral Heuristics in Coronary-Artery Bypass Graft Surgery
Eric Topol 1 of the ~200 cognitive biases of doctors—"left-digit bias—has been shown for diagnosis of heart attacks (age < 40) and now for bypass surgery (>80) 28h
How Common Mental Shortcuts Can Cause Major Physician Errors
Nytimes.com 31h 10 tweets
Tendencies like left-digit bias can have life-altering consequences for patients.
Eric Topol 1 of the ~200 cognitive biases of doctors—"left-digit bias—has been shown for diagnosis of heart attacks (age < 40) and now for bypass surgery (>80) 28h
Stalled Federal Efforts to End Surprise Billing — The Role of Private Equity | NEJM
New England Journal of Medicine 45h 1 tweets
Perspective from The New England Journal of Medicine — Stalled Federal Efforts to End Surprise Billing — The Role of Private Equity
Eric Topol Adding to the surprise: the role of private equity investment companies by 45h
Cellular and Molecular Probing of Intact Human Organs
Cell 8d 8 tweets
Zhao et al. present an approach for intact human organ mapping that uses a new tissue permeabilization method to clear and deeply label whole organs followed by light-sheet microscopy imaging and a deep learning-based pipeline for 3D reconstruction...
Eric Topol —"We need to make #deeplearning #AI more transparent" —"OK, how about we use it to make organs transparent?" 😉 by See thru #3D brain, eye, kidney, thyroid 47h