Alessandro Gozzi
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PhD studentship, neuroimaging and computational neuroscience - jobRxiv
jobRxiv - jobRxiv 88d 1 tweets
jobRxiv is the free and international job board for scientists, by scientists. Find hundreds of job offers like this one at jobRxiv!
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Alessandro Gozzi Two fully-funded #PhD scholarship (2021-2024) in my lab in #Rovereto ➡️ Neuroimaging and computational neuroscience ➡️ fMRI and circuit physiology Check-out links for more info on project & selection RTs are welcome : ) 88d
PhD studentship, neuroimaging and circuit physiology - jobRxiv
jobRxiv - jobRxiv 88d 1 tweets
jobRxiv is the free and international job board for scientists, by scientists. Find hundreds of job offers like this one at jobRxiv!
2
Alessandro Gozzi Two fully-funded #PhD scholarship (2021-2024) in my lab in #Rovereto ➡️ Neuroimaging and computational neuroscience ➡️ fMRI and circuit physiology Check-out links for more info on project & selection RTs are welcome : ) 88d
Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes
bioRxiv 95d 2 tweets
Autism Spectrum Disorder (ASD) is characterized by substantial, yet highly heterogeneous abnormalities in functional brain connectivity. However, the origin and significance of this phenomenon remain unclear. To unravel ASD connectopathy and relate...
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Alessandro Gozzi Can we ‘see’ #autism in the brain? And is there a specific brain signature for the condition? This is what we found by comparing brain connectivity maps across 16 mouse autism models ➡️ ➡️Majestically led 👏👏👏by Thread 1/n 95d
A cross‐species link between mTOR‐related synaptic pathology and functional hyperconnectivity in autism
bioRxiv 103d 2 tweets
Postmortem studies have revealed increased density of excitatory synapses in the brains of individuals with autism, with a putative link to aberrant mTOR-dependent synaptic pruning. Autism is also characterized by atypical macroscale functional...
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Alessandro Gozzi #Autism is often associated with an excess of synapses: but how does this trait affect large-scale circuit function? Here's what we found by modelling autism-related pruning deficits across-species🧠🐭 ➡️ By & al. Thread 1/n 102d
Thread by @Gozzi_Ale: Wondering whether axonal input *drives* fMRI-based functional connectivity? Us too! Here is what we found using #chemogenetic deconstruction…
Alessandro Gozzi - Threadreaderapp.com 165d 1 tweets
Thread by @Gozzi_Ale: Wondering whether axonal input *drives* fMRI-based functional connectivity? Us too! Here is what we found using #truction of rsfMRI in the mouse Cortical silencing results in paradoxical fMRI overconnectivity tinyurl.com/…
Linking Structure and Function in Macroscale Brain Networks
Trends in Cognitive Sciences 165d 1 tweets
Structure–function relationships are a fundamental principle of many naturally occurring systems. However, network neuroscience research suggests that there is an imperfect link between structural connectivity and functional connectivity in the...
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Alessandro Gozzi Computational and empirical evidence suggest that structural and functional connectivity are robustly related ➡️ this recent review from summarizes it all 2/n 165d
Cortical silencing results in paradoxical fMRI overconnectivity
bioRxiv 165d 1 tweets
fMRI-based measurements of functional connectivity are commonly interpreted as an index of anatomical coupling and direct interareal communication. However, causal testing of this hypothesis has been lacking. Here we combine neural silencing,...
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Alessandro Gozzi Wondering whether axonal input *drives* fMRI-based functional connectivity? Us too! Here is what we found using #chemogenetic deconstruction of rsfMRI in the mouse🐁🐭 ➡️Cortical silencing results in paradoxical fMRI overconnectivity Thread below 1/n 165d
Autism: Balancing excitation and inhibition in the autistic brain
eLife 168d 2 tweets
A metric called the Hurst exponent could be a useful biomarker for studies exploring brain differences between men and women with autism spectrum disorder.
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Alessandro Gozzi Towards a reverse engineering of fMRI signal in #autism: ➡️nice commentary by on our collaborative work with entailing use of 🐁chemogenetic-fMRI to probe Excitation : Inhibition balance in #Autism 168d
Converging structural and functional evidence for a rat salience network
Biological Psychiatry 200d 1 tweets
The salience network (SN) is dysregulated in many neuropsychiatric disorders, including substance use disorder. Initially described in humans, identification of a rodent SN would provide the ability to mechanistically interrogate this network in...
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Alessandro Gozzi Converging structural and functional evidence for a rat salience network 1/2 200d
Postdoctoral Position in Neuroscience and Circuit Physiology
Iit.it 224d 1 tweets
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Alessandro Gozzi New lab spaces is now available 🙂& with that comes further recruitment! Seeking a post doc interested in joining our project aimed at investigating neural basis of functional dysconnectivity via neuromanipulations in 🐭🐁 Full story here➡️ 224d
A generative modeling approach for interpreting population-level variability in brain structure
bioRxiv 227d 3 tweets
Understanding how neural structure varies across individuals is critical for characterizing the effects of disease, learning, and aging on the brain. However, disentangling the different factors that give rise to individual variability is still an...
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Alessandro Gozzi A generative modeling approach for interpreting population-level variability in brain structure 225d
Ultra-high field (10.5 T) resting state fMRI in the macaque
bioRxiv 241d 2 tweets
Resting state functional connectivity refers to the temporal correlations between spontaneous hemodynamic signals obtained using functional magnetic resonance imaging. This technique has demonstrated that the structure and dynamics of identifiable...
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Alessandro Gozzi Ultra-high field (10.5 T) resting state fMRI in the macaque 240d
Individual Fellowships 2020 - Marie Skłodowska-Curie Actions - European Commission
Marie Skłodowska-Curie Actions - European Commission 271d 6 tweets
Individual Fellowships 2020
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Alessandro Gozzi If you are interested in #mouse #connectomics #fMRI #autism or #neurophysiology #chemogenetics and have good track record in any of these fields consider applying to a fellowship with us ➡️ DM or email me for further info 🐁🐭🧠 #MSCA 244d
Regional, layer, and cell-class specific connectivity of the mouse default mode network
bioRxiv 250d 3 tweets
The evolutionarily conserved default mode network (DMN) is characterized by temporally correlated activity between brain regions during resting states. The DMN has emerged as a selectively vulnerable network in multiple disorders, so understanding...
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Alessandro Gozzi **New preprint from the lab** Regional, layer and cell-class specific connectivity of the mouse default mode network Conceived & majestically led by Thread covering DMN basics + implications of findings 1/n 👇 249d
The M1/M4 agonist xanomeline modulates functional connectivity and NMDAR antagonist−induced changes in the mouse brain
bioRxiv 260d 1 tweets
Cholinergic drugs acting at M1/M4 muscarinic receptors hold promise for the treatment of symptoms associated with brain disorders characterized by cognitive impairment, mood disturbances or psychosis, such as Alzheimer's disease or schizophrenia....
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Alessandro Gozzi A venture into muscarinic pharmacology in our new preprint here with two take-home messages for brain connetivologists 👉Cholinergic activation *reduces* rsfMRI connectivity 👉Psychotogenic drugs (e.g. ketamine) *increase* thalamo-cortical connectivity 260d
Towards Neurosubtypes in Autism
Sciencedirect.com 271d 2 tweets
There is a general consensus that substantial heterogeneity underlies the neurobiology of autism spectrum disorder (ASD). As such, it has become incre…
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Alessandro Gozzi Live today 👉Towards Neurosubtypes in Autism With & Adriana Di Martino 270d
A platform for brain-wide functional ultrasound imaging and analysis of circuit dynamics in behaving mice
bioRxiv 280d 1 tweets
Imaging of large-scale circuit dynamics is crucial to gain a better understanding of brain function, but most techniques have a limited depth of field. Here we describe vfUSI, a platform for brain-wide volumetric functional ultrasound imaging of...
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Alessandro Gozzi A platform for brain-wide functional ultrasound imaging and analysis of circuit dynamics in behaving mice From & colleagues 280d
A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation
bioRxiv 294d 4 tweets
The isocortex and hippocampal formation are two major structures in the mammalian brain that play critical roles in perception, cognition, emotion and learning. Both structures contain multiple regions, for many of which the cellular composition is...
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Alessandro Gozzi New outstanding neuro-resource from 👉A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation 293d
Noradrenergic locus coeruleus ensembles evoke different states in rat prefrontal cortex
bioRxiv 294d 1 tweets
Identifying the neurons that control global brain state has been a fundamental topic of research that has largely focused on diffusely-projecting neuromodulatory centers, such as the locus coeruleus (LC). This noradrenergic brain stem nucleus, which...
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Alessandro Gozzi Noradrenergic locus coeruleus ensembles evoke different states in rat prefrontal cortex --> LC differentiates neuromodulation of its forebrain targets by dynamic firing patterns of LC ensambles <-- From #Stefano_Panzeri et al. 294d
A letter to the UK from Italy: this is what we know about your future
the Guardian 298d 62 tweets
An author in Rome describes what to expect based on her experiences of lockdown
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Alessandro Gozzi A letter to the UK from Italy: this is what we know about your future 297d