Harmit Malik
Study genetic conflicts professionally. Try to avoid conflicts in personal life (with mixed results).
Last synced from Twitter 4m ago
Measles Kills Thousands in Democratic Republic of Congo
Deaths attributed to the disease have outpaced those from Ebola this year.
Harmit Malik
Measles Kills Thousands in Democratic Republic of Congo
3h
Tetrad analysis without tetrad dissection: Meiotic recombination and genomic diversity in the yeast Komagataella phaffii (Pichia pastoris)
Komagataella phaffii is a yeast widely used in the pharmaceutical and biotechnology industries, and is one of the two species that were formerly called Pichia pastoris. However, almost all laboratory work on K. phaffii has been done on strains...
Adaptive evolution of a rock-paper-scissors sequence along a direct line of descent
Non-transitivity - commonly illustrated by the rock-paper-scissors game - is purported to be common in evolution despite a lack of examples of non-transitive interactions arising along a single line of descent. We identify a non-transitive...
Student with autism gets diploma, honored with supportive, silent ovation
These upstate high school graduates made the commencement day extra special for their autistic classmate — by staying absolutely silent as he walked across the stage to receive his diploma, a…
Harmit Malik
Student with autism gets diploma, honored with supportive, silent ovation nypost.com/2019/07/10/stu… via @nypmetro
16h
Cricket World Cup final: Former top umpire Simon Taufel says England should have been awarded five runs, not six, in crucial moment
Former leading umpire Simon Taufel: There was a judgment of error on crucial overthrows.
Police arrests 27-year-old farmer for the murder of Suzanne Eaton UPD
A 27-year-old suspect has been arrested by police for the murder of US biologist Suzanne Eaton. Acco
Thief hides in suitcase to steal bags in Spanish airport bus - Expat Guide to Spain |
A flexible thief squeezed into a large suitcase and then emerged to plunder valuables from other bags while inside the luggage compartment of a Spanish airport bus, police...
Modulation of Angiogenic Processes by the Human Gammaherpesviruses, Epstein–Barr Virus and Kaposi’s Sarcoma-Associated Herpesvirus
Angiogenesis is the biological process by which new blood vessels are formed from pre-existing vessels. It is considered one of the classic hallmarks of cancer, as pathological angiogenesis provides oxygen and essential nutrients to growing tumors....
IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise
A critical step of placental development is the fusion of trophoblast cells into a multi-nucleated syncytiotrophoblast layer. Trophoblast fusion is mediated by syncytins, encoded by endogenous retrovirus–derived envelope glycoproteins. Buchrieser et...
Auxin-inducible protein degradation as a novel approach for protein depletion and reverse genetic discoveries in mammalian oocytes
Abstract. The disruption of protein expression is a major approach used for investigating protein function in mammalian oocytes. This is often achieved with RN
The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus. - PubMed - NCBI
PubMed comprises more than 29 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death
Activation of the cytoplasmic DNA sensor cGAS is inhibited by nucleosomes during normal
mitosis, but during prolonged mitotic arrest, cGAS functions to promote cell death
via slowly accumulating phosphorylation of IRF3.
Interferon-Stimulated Genes: What Do They All Do?
In the absence of an intact interferon (IFN) response, mammals may be susceptible to lethal viral infection. IFNs are secreted cytokines that activate a signal transduction cascade leading to the induction of hundreds of interferon-stimulated genes...
IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise
The placenta is the primary maternal–fetal barrier, achieving metabolic exchanges, hormone production, and protection from pathogens and the maternal
2
Harmit Malik
IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise. When reproduction depends on a protein derived from a retroviral envelope, antiviral genes that block env fusion are very bad. What a creative and important finding!!!
5d
Reimagining Peer Review
.Reimagining Peer Review. .Jessica Polka. .2019-07-11. .Executive Director, ASAPbio. [email protected], @ASAPbio_. .#ReimagineReview. In this interactive session, we will: Take a bird's eye view of the history of peer review Review its strengths and...
Ancient epigenetic changes silence cancer-linked genes
A study in zebrafish indicates that some genes linked to cancers in humans have been strictly regulated throughout evolution.
The cytoplasmic DNA sensor cGAS promotes mitotic cell death
The cyclic GMP-AMP (cGAMP) synthase cGAS counteracts infections by detecting and binding foreign cytoplasmic DNA[1][1]. DNA-induced synthesis of cGAMP activates innate immune signalling and apoptosis through the cGAMP receptor STING and the...