Conflicts between viruses and their hosts drive the evolution of antiviral restriction
factors. Boys et al. unveil mammalian RTP4 as an antiviral effector that suppresses
the replication of distinct flaviviruses in a species-specific manner, thus...
The Wtf4 antidote protein assembles with the Wtf4 poison protein and promotes the transportation of the assembled proteins to the vacuole for sequestration or destruction.
Two researchers claim that a single number they call the “political stress indicator” can warn when societies are at risk of erupting into violence. It’s spiking in the US, just like it did before the Civil War.
Shoba Subramanian explores the professional challenges international grad students and postdocs continue to face -- and offers some advice to them as well as their academic colleagues.
The Ford Foundation seeks to increase the diversity of the nation’s college and university faculties by increasing their ethnic and racial diversity, to maximize the educational benefits of diversity, and to increase the number of professors who can...
SHOUTS AND MURMURS about undecided voters. As we move into the final weeks of the Presidential campaign, the focus shifts to the undecided voters. I look …
Mutations in mtDNA-encoded components of the mitochondrial translational apparatus are associated with diverse pathological states in humans, notably sensorineural deafness. To develop animal models of such disorders, we have manipulated the nuclear...
For Washingtonians feeling stressed, anxious or depressed because of the COVID-19 pandemic, a state call line offers a listening ear or connections to help.
Pyrosomes are tunicates in the phylum Chordata, which also contains vertebrates. Their gigantic blooms play important ecological and biogeochemical roles in oceans. Pyrosoma, meaning “fire-body”, derives from their brilliant bioluminescence. The...
The evolutionary arms race between hosts and their viruses drove the evolution of complex immune systems in mammals and sophisticated immune evasion mechanisms by viruses. Mammalian antiviral defences require sensing of virus infection and...
A massively multiplexed multi-condition screen shows that protein interactomes are larger than previously thought and contain highly dynamic regions that reorganize to drive or respond to cellular changes.