Ioana A. Cristea
Psychologist, (meta)researcher, overall skeptic, daydreamer, mind-wanderer, traveller, she/her. Assistant Prof Affiliate
Last synced from Twitter 1340d ago
Time to Reassess Tocilizumab’s Role in COVID-19 Pneumonia
Jamanetwork.com 97d 10 tweets
In this issue of JAMA Internal Medicine, 3 important articles1-3 explore the use of tocilizumab in coronavirus disease 2019 (COVID-19) pneumonia. Tocilizumab is a humanized monoclonal antibody that binds human interleukin 6 (IL-6) receptors. It is...
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Ioana A. Cristea Two new RCTs just out show no/limited (nothing on mortality) benefits of #Tocilizumab in #SARSCoV2. Large observational study in same issue show reduced mortality. Get popcorn. 97d
It’s Time to Put Children and Young People First During the Global COVID-19 Pandemic
Jamanetwork.com 122d 7 tweets
Children have been relatively spared from the effect of clinical coronavirus disease 2019 (COVID-19). The newly described inflammatory syndrome1,2 is rare in terms of the total population of children, and severe acute forms of COVID-19 are even...
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Ioana A. Cristea Great editorial by & , emphasizing that long-term effects and children's well-being SHOULD also matter, not just their role in the transmission chain. You'd think we'd have heard this sooner. I certainly did not. 122d
Punishment by Pandemic
Rachel Aviv - The New Yorker 225d 15 tweets
In a penitentiary with one of the U.S.’s largest coronavirus outbreaks, prison terms become death sentences.
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Ioana A. Cristea I know it's not a scientific article, but I am posting it here too because U think it's illuminating about #SARSCoV2 and American prisons (from ) 152d
Work honored by Nobel prizes clusters heavily in a few scientific fields
Journals.plos.org 179d 4 tweets
We aimed to assess whether Nobel prizes (widely considered the most prestigious award in science) are clustering in work done in a few specific disciplines. We mapped the key Nobel prize-related publication of each laureate awarded the Nobel Prize...
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Ioana A. Cristea Happy to have contributed to this w/ John Ioannidis & Kevin Boyack. Main message: work resulting in Nobel prizes is concentrated in a minority of scientific disciplines. 179d
The New Stability | NEJM
New England Journal of Medicine 190d 14 tweets
Perspective from The New England Journal of Medicine — The New Stability
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Ioana A. Cristea From one of the most heart-breaking, soul-wrenching, devastating pieces I read in a long time "I look for hope and find none, but I am not allowed to admit to total free fall." 189d
Challenges and Opportunities for Human Behavior Research in the Coronavirus Disease (COVID-19) Pandemic
Frontiers 192d 1 tweets
The COVID-19 pandemic is a serious public health crisis causing major worldwide disruption. So far, the most widely deployed interventions have been non-pharmacological (NPI), such as various forms of social distancing, pervasive use of personal...
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Ioana A. Cristea My first #COVID19 #coronavirus published (as opposed to unpublished :)) piece (w/ ) out 192d
FDA Permits Marketing of First Game-Based Digital Therapeutic to Improve Attention Function in Children with ADHD
U.S. Food and Drug Administration 224d 9 tweets
FDA permits marketing of the first game-based digital therapeutic device, EndeavorRx, for children with ADHD.
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Ioana A. Cristea Oh boy. (The only andomized trial: ) 224d
Akili Announces FDA Clearance of EndeavorRxTM for Children with ADHD, the First Prescription Treatment Delivered Through a Video Game
Businesswire.com 224d 1 tweets
Akili Announces FDA Clearance of EndeavorRx for Children with ADHD, the First Prescription Treatment Delivered Through a Video Game
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Ioana A. Cristea Oh boy. (The only andomized trial: ) 224d
A novel digital intervention for actively reducing severity of paediatric ADHD (STARS-ADHD): a randomised controlled trial
The Lancet Digital Health 336d 4 tweets
Although future research is needed for this digital intervention, this study provides evidence that AKL-T01 might be used to improve objectively measured inattention in paediatric patients with ADHD, while presenting minimal adverse events.
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Ioana A. Cristea Oh boy. (The only andomized trial: ) 224d
Which interventions work best in a pandemic?
Science 235d 4 tweets
The only approaches currently available to reduce transmission of the novel coronavirus severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) are behavioral: handwashing, cough and sneeze etiquette, and, above all, social distancing....
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Ioana A. Cristea Very important paper We CAN and SHOULD conduct randomized trials of non-pharmacological interventions (e.g., social distancing) in the #SARSCoV2 pandemic. Why haven't we? 229d
John Ioannidis and Medical Tribalism in the Era of Covid-19
Undark Magazine 229d 15 tweets
The critical questions the Stanford professor is raising about Covid-19 have gotten lost amid partisan bickering.
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Ioana A. Cristea Yeah, I pretty much stand by everything in this article 229d
Convalescent Plasma Therapy and Clinical Improvement in Severe and Life-threatening COVID-19
Jamanetwork.com 237d 45 tweets
This randomized trial compares the effects of convalescent plasma therapy with standard care vs standard care alone on time to clinical improvement among patients with severe or life-threatening COVID-19 disease in China.
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Ioana A. Cristea In all this retraction/hydroxychloroquine frenzy, I feel there is too little interest over another hyped treatment having taken its place in the "probably not a game changer" category, which is a new #COVIDー19 inspired category of treatment effectiveness 234d
Retraction: "Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis"
Thelancet.com 235d 19 tweets
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Ioana A. Cristea Last week: suspend all hydroxychloroquine arms, stat, nevermind data monitoring committees, compromised equipoise, patient trust etc This week: notice of retraction #classicCovid research (a perfect hashtag stolen from ) 235d
Clinical efficacy of cognitive bias modification interventions
The Lancet Psychiatry 249d 2 tweets
Reducing the health burden of depression and anxiety disorders requires improvement in both treatment outcomes and the accessibility of treatment approaches. Interventions based on cognitive bias modification (CBM)1 have been suggested as one...
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Ioana A. Cristea Thoughtful invited comment , who unlike me, also conducts primary research in this field 240d
Efficacy of cognitive bias modification interventions in anxiety and depressive disorders: a systematic review and network meta-analysis
The Lancet Psychiatry 250d 3 tweets
CBM interventions showed consistent but small benefits; however heterogeneity and risk of bias undermine the reliability of these findings. Larger, definitive trials for interpretation bias modification for anxiety might be warranted, but...
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Ioana A. Cristea My new & very likely most important paper of 2020 #network #metaanalysis on the efficacy of cognitive bias modification for #anxiety or #depression in clinical or subclinical patients (1st author , w/ ) 240d
Universal Masking in Hospitals in the Covid-19 Era | NEJM
New England Journal of Medicine 248d 1 tweets
Perspective from The New England Journal of Medicine — Universal Masking in Hospitals in the Covid-19 Era
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Ioana A. Cristea Ouch "Expanded masking protocols’ greatest contribution may be to reduce the transmission of anxiety, over and above whatever role they may play in reducing transmission of Covid-19." 248d
Industry-funded Versus Non-Profit-Funded Critical Care Research: A Meta-Epidemiological Overview - PubMed
PubMed 269d 1 tweets
Industry-funded RCTs are the minority in intensive care. We found no evidence that industry-funded trials in intensive care yield more favorable results or are less likely to reach unfavorable conclusions.
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Ioana A. Cristea Noone is really out there to show research is all wrong, and less of all John Ioannidis. For instance, in a paper we co-authored we had no "psychological COI" to report the absence of differences between industry-funded vs non-funded trials. 5/ 269d
A Prophet of Scientific Rigor—and a Covid Contrarian
Wired 270d 25 tweets
John Ioannidis laid bare the foibles of medical science. Now medical science is returning the favor.
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Ioana A. Cristea I am sorry but this article is a pretty sloppy caricature of John Ioannidis. (whose article is how I told my parents who I was going to do my with), sadly has not kept up w/ John's work or meta-research 1/ 269d
Data on Gilead's remdesivir show no benefit for coronavirus patients
STAT 278d 52 tweets
The antiviral medicine remdesivir from Gilead Sciences failed to speed the improvement of patients in China with Covid-19 or prevent them from dying.
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Ioana A. Cristea We gave up on #evidence based #medicine in the face of the #SARS_CoV2 #COVID19 pandemic. We are now at medicine based on data leaks. This is beyond non-peer-reviewed preprint. We are at "accidentally leaked data" 278d
The Rising Heroes of the Coronavirus Era? Nations’ Top Nerds
Nytimes.com 296d 34 tweets
Scientists in Europe are becoming household names, fulfilling societies’ emotional and practical need for the truth.
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Ioana A. Cristea In 2020 runs a piece about the "rising heroes of the coronavirus era", the "nations' top scientists" fighing the #SARSCoV2. All those featured are men. With one exception: Elaine Kinsella who researches "the role of heroes in society" #metairony 295d