JExpMed
The Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, neurobiology. Est. 1896 -
Last synced from Twitter 90d ago
ICIS 2020 Honorary Lifetime Membership Award bestowed on Anne O’Garra
Cytokines - International Cytokine & Interferon Society 91d 1 tweets
Anne O’Garra is honored with the ICIS 2020 Honorary Lifetime Membership Awards as a tribute to her seminal and original contributions to our understanding of the role of cytokines in immunobiology …
JExpMed We congratulate Anne O’Garra (JEM Academic Editor) and Vijay K. Kuchroo (JEM Advisory Editor) for winning 2020 awards presented by 🏆 #cytokines2020 91d
2020 BioLegend William E. Paul Award for Excellence in Cytokine Research
International Cytokine & Interferon Society 91d 1 tweets
Professors Sarah Gaffen and Vijay Kuchroo are being jointly recognised for the ICIS-BioLegend William E. Paul award for their combined contribution deciphering the role of a key cytokine IL-17 in h…
JExpMed We congratulate Anne O’Garra (JEM Academic Editor) and Vijay K. Kuchroo (JEM Advisory Editor) for winning 2020 awards presented by 🏆 #cytokines2020 91d
Biology and therapeutic potential of interleukin-10 | Journal of Experimental Medicine | Rockefeller University Press
Rupress.org 91d 1 tweets
JExpMed Saraiva, O’Garra, & Vieira review molecular mechanisms regulating IL-10 production & response and describe classic and novel functions of IL-10 in immune and non-immune cells (). From Review Focus for #Cytokines2020: #JEMCytokines 91d
Search Results | RUP
Rupress.org 91d 1 tweets
JExpMed Saraiva, O’Garra, & Vieira review molecular mechanisms regulating IL-10 production & response and describe classic and novel functions of IL-10 in immune and non-immune cells (). From Review Focus for #Cytokines2020: #JEMCytokines 91d
Sustained androgen receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis | Journal of Experimental Medicine | Rockefeller University Press
Rupress.org 91d 1 tweets
JExpMed Ma, Ghosh, et al. uncover an essential role of AR signaling in melanoma cell expansion & tumorigenesis, w/ loss of AR activity inducing cellular senescence, genomic DNA breakage, STING dependent inflammatory cascade & immune cells recruitment. 91d
Search Results | RUP
Rupress.org 91d 1 tweets
JExpMed For #cytokines2020 virtual meeting (Nov 1-4), read our recent series of reviews focused on the diverse functions of #cytokines. #JEMcytokines 91d
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Rupress.org 91d 3 tweets
<p><em>JEM </em>is pleased to present a special collection of articles relevant to the Cytokines 2020 Structure-Function and Systems Biology of Cytokine Actions virtual meeting, as well as our <a...
JExpMed We're pleased to present a special collection of recent articles relevant to the 's Virtual Meeting: Structure-Function and Systems Biology of Cytokine Actions #Cytokines2020. We hope you enjoy the collection and welcome your feedback! 91d
JExpMed Mouse model of #SARSCoV2 reveals inflammatory role of type I interferon signaling, by et al. (). Part of a special collection of JEM articles on #cytokines to accompany #cytokines2020 virtual meeting: 91d
Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility | Journal of Experimental Medicine | Rockefeller University Press
Rupress.org 92d 1 tweets
JExpMed People with an unusual NFKB2 gene often get autoimmune diseases. Rushika Wirasinha, Ainsley Davies , Matthew Cook Stephen Daley , and colleagues found this stems from a problem in the #thymus. #Autoimmunity 92d
Multi-transcription factor reporter mice delineate early precursors to the ILC and LTi lineages | Journal of Experimental Medicine | Rockefeller University Press
Rupress.org 93d 1 tweets
JExpMed Darshan N. Kasal and Albert Bendelac dissect the developmental progression of innate lymphoid cell and lymphoid tissue inducer lineages, and indicate earlier bifurcation of the two lineages than formerly proposed. #Hematopoiesis 93d
Distinct integrin activation pathways for effector and regulatory T cell trafficking and function | Journal of Experimental Medicine | Rockefeller University Press
Rupress.org 93d 1 tweets
JExpMed Sun, Ginsberg, , et al. show that the wiring diagram of signaling pathways that control integrin activation & the functions of T reg cells differs from that of effector T cells, suggesting new approaches to inhibit effector T cells 93d
Adiponectin restrains ILC2 activation by AMPK-mediated feedback inhibition of IL-33 signaling | Journal of Experimental Medicine | Rockefeller University Press
Rupress.org 93d 1 tweets
JExpMed Lu Wang, Meilian Liu (), Xuexian Yang and colleagues reveal that adiponectin signaling via AMPK acts as a negative regulator of ILC2s and exerts an anti-thermogenic effect #InnateImmunity #inflammation #Metabolism 93d
Charles E. Egwuagu: Going with the flow | Journal of Experimental Medicine | Rockefeller University Press
Rupress.org 96d 1 tweets
JExpMed Houston chatted with Charles E. Egwuagu of the Molecular Immunology Section at . His lab is focused on understanding the role played by #lymphocytes in autoimmune diseases of the central nervous system. 96d
Lysosomal cathepsin creates chimeric epitopes for diabetogenic CD4 T cells via transpeptidation | Journal of Experimental Medicine | Rockefeller University Press
Rupress.org 96d 1 tweets
JExpMed Brendan Reed, John Kappler et al show the lysosomal protease cathepsin L uses pancreatic secretory granule protein precursors & a reverse proteolysis mechanism to generate chimeric super-epitopes specific for diabetogenic CD4 T cells #diabetes 96d
T reg cell–intrinsic requirements for ST2 signaling in health and neuroinflammation | Journal of Experimental Medicine | Rockefeller University Press
Rupress.org 96d 1 tweets
JExpMed Saskia Hemmers, Michail Schizas & Alexadnder Rudensky uncover a novel ST2-dependent role for T reg cells in limiting the size of IL-17A–producing γδT cells in the CNS in a mouse model of #neuroinflammation #Autoimmunity 96d
Longevity, clonal relationship, and transcriptional program of celiac disease–specific plasma cells | Journal of Experimental Medicine | Rockefeller University Press
Rupress.org 96d 1 tweets
JExpMed Single-cell analysis by Lindeman , Sollid, , et al. reveals an accumulation of short-lived disease-specific & non-disease-specific intestinal plasma cells in untreated & short-term-treated #celiac disease. #Autoimmunity 96d
α-Synuclein modulates tau spreading in mouse brains | Journal of Experimental Medicine | Rockefeller University Press
Rupress.org 96d 1 tweets
JExpMed Fares Bassil, Virginia Man-Yee Lee et al. model the cross-talk of α-syn and tau under co-pathology conditions. They show evidence of alpha-synuclein dependent tau pathology in the human brain. #Neuroscience #Alzheimers #Parkinsons 96d
Faculty Opinions Recommended Article: Poor quality Vβ recombination signal sequences stochastically enforce TCRβ allelic exclusion.
Facultyopinions.com 99d 1 tweets
Read the latest recommendation by Karla Rodgers from the Immunology Faculty, at Faculty Opinions.
JExpMed A recent study by Wu () et al. () "shows evidence that a key determinant contributing to the allelic exclusion of the Tcrb gene in T cells lies at the genetic level." Highlighted in : #Goodforteaching 99d
Phenotypic and functional characterization of first-trimester human placental macrophages, Hofbauer cells | Journal of Experimental Medicine | Rockefeller University Press
Rupress.org 100d 4 tweets
JExpMed Jake Thomas, Naomi McGovern and colleagues , , find that Hofbauer cells (HBCs) are primitive macrophages with a unique phenotype and role in fetal defence. #macrophages #placenta #InnateImmunity 100d
JExpMed Phenotypic and functional characterization of first-trimester human placental #macrophages, Hofbauer cells (HBCs). From Jake Thomas and colleagues , , : #placenta #InnateImmunity #inflammation 93d
JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML | Journal of Experimental Medicine | Rockefeller University Press
Rupress.org 100d 2 tweets
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JExpMed ., de Thé, et al. demonstrate that arsenic trioxide sharply potentiates interferon's ability to eliminate patients progenitors or disease-initiating cells from mouse models, by targeting PML, an interferon target. 100d
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JExpMed JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML, say Dagher , Maslah , de Thé, Kiladjian , Villeval & colleagues : #Leukemia #Lymphoma 93d
Regulatory roles of IL-10–producing human follicular T cells | The Journal of Experimental Medicine | Rockefeller University Press
Rupress.org 393d 2 tweets
JExpMed Regulatory roles of IL-10–producing human follicular T cells, by Pablo Cañete et al. From our special collection "Germinal Centers and Immune Niches," highlighting the latest discoveries related to germinal center biology: 100d