Johanna Joyce
Cancer biologist #tumormicroenvironment enthusiast @Joycelab
Executive director Agora Cancer Center Lausanne
@unil @Ludwig_Cancer @OncoUNILCHUV
Educator, Mum
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Covid-19 expert Akiko Iwasaki fights a different virus: sexism in science
To know virologist Akiko Iwasaki is to know that she is passionate about combatting sexism, power imbalance, and toxic behavior in academia.
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Johanna Joyce
A must-read profile of Akiko Iwasaki @VirusesImmunity - despite the injustices she has encountered & witnessed, her kindness & generosity to all shines through at every turn.
She is a role model beyond compare.
statnews.com/2020/10/27/aki… via @statnews
90d
A Medical Revolution Too Late for the Man Who Started It
Sam Gambhir reimagined the field of cancer detection. Then he got cancer.
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Johanna Joyce
Beautiful article about Sam Gambhir, the pioneering cancer detector @StanfordMed @Ludwig_Cancer who sadly died at just 57 yrs old from cancer, the disease he had dedicated his life to finding and fighting.
Madeline Drexler @TheAtlantic
95d
Modeling the Interaction between the Microenvironment and Tumor Cells in Brain Tumors
In this review, Pasqualini et al. describe the tumor microenvironment in brain cancers
and its impact on tumor behavior. They discuss how, compared to current preclinical
models, humanized animals and organoids will allow more accurate evaluations...
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Johanna Joyce
New review on the brain #TumorMicroenvironment with a focus on the best systems to model the #TME
Claudia Pasqualini, Jacques Grill @GustaveRoussy @FGinhoux et al..
Modeling the Interaction between the Microenvironment and Tumor Cells in Brain Tumors
101d
Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies
Single-cell RNA sequencing analysis shows that CD19, primarily considered as a B cell-specific
surface antigen, is expressed in human brain mural cells that are critical for blood-brain-barrier
integrity, suggesting that this cell population may...
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Johanna Joyce
Insightful analysis of #singlecell RNAseq data reveals CD19 in brain mural cells- providing an explanation for neurotoxicity in CD19-directed #immunotherapies.
Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies
125d
Immunometabolism in the Brain: How Metabolism Shapes Microglial Function
Immune cells react to their environment by flexibly reprogramming intracellular metabolic
pathways that subsequently alter immune function, in a process called immunometabolism.
However, in the CNS, the impact of metabolic reprogramming on...
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Johanna Joyce
Another great new review on the fascinating functions of #microglia in the brain!
In this @TrendsNeuro article, @LPBernier @elimyork @brian_macvicar discuss #metabolic reprogramming in #neuroinflammation & how this can go awry..
Brain Immunometabolism
126d
Homeostatic mini-intestines through scaffold-guided organoid morphogenesis
Miniature gut tubes grown in vitro from mouse intestinal stem cells are perfusable, can be colonized with microorganisms and exhibit a similar arrangement and diversity of specialized cell types to intestines in vivo.
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Johanna Joyce
Congratulations to @mike_nikolaev, Matthias & all authors @TheLutolfLab @EPFL_en for this amazing study pushing the frontiers of #organoid research to study intestine functions incl. host–microorganism interactions!
130d
Interleukin-2 signals converge in a lymphoid–dendritic cell pathway that promotes anticancer immunity
Interleukin-2 (IL-2) is an immunostimulatory cytokine that is being tested as an anticancer therapy due to its ability to activate T cells and natural killer cells. Unexpectedly, Raeber et al . discovered that IL-2 can also activate dendritic cells,...
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Johanna Joyce
New @ScienceTM study from Raeber, Boyman et al @UZH_en revealing intriguing roles for IL-2 in expansion of DCs, and promoting anti-tumor immunity in a DC-dependent manner
#TumorMicroenvironment
130d
Single-Cell Analysis Reveals Fibroblast Clusters Linked to Immunotherapy Resistance in Cancer
A subset of cancer-associated fibroblasts (FAP+/CAF-S1) mediates immunosuppression in breast cancers, but its heterogeneity and its impact on immunotherapy response remain unknown. Here, we identify 8 CAF-S1 clusters by analyzing more than 19,000...
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Johanna Joyce
Fascinating study from @FatimaMechta et al using #singlecell analyses to identify CAF clusters associated w/ ICI resistance, validated across different cancers
Single-Cell Analysis Reveals Fibroblast Clusters Linked to Immunotherapy Resistance in Cancer cancerdiscovery.aacrjournals.org/content/10/9/1… pic.twitter.com/n5ssqR96wq
145d
Immune crosstalk in cancer progression and metastatic spread: a complex conversation
Immune subversion by primary tumours plays a key role in metastatic spread. This Review explores how primary tumours interfere with the crosstalk between immune cells to promote a chronic inflammatory yet immunosuppressed state that enables immune...
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Johanna Joyce
Great new review on the complex interplay between the #immune system and cancer cells during #metastasis by Hannah Garner & Karin de Visser @NKI_nl - in the August issue of NRI
go.nature.com/2vTuWf1
@NatRevImmunol @NatResCancer
181d
Biological functions of lymphatic vessels
Lymphatic vessels are spread throughout the human body and have critical functions in mammalian physiology. Petrova et al. review emerging roles of the lymphatic vasculature in organ function and pathology and provide perspectives beyond the...
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Johanna Joyce
Wonderful @ScienceMagazine review by Tanya Petrova @unil @OncoUNILCHUV and Gou Young Yoh @gou_koh covering everything you ever wanted to know about lymphatics from cancer to the CNS!
Biological functions of lymphatic vessels
195d