Daily aspirin reduces the long-term incidence of some adenocarcinomas, but effects on mortality due to some cancers appear after only a few years, sug…
P. D. Mangan 🇺🇸Effect of daily aspirin on risk of cancer metastasis
Large reductions (up to 75%) in metastasis in patients on aspirin.
Decreased "metastasis could account for the early reduction in cancer deaths in trials of daily aspirin versus control."
We now know that depression is associated with a chronic, low-grade inflammatory response and activation of cell-mediated immunity, as well as activation of the compensatory anti-inflammatory reflex system. It is similarly accompanied by increased...
Previous efforts to forecast future trends in obesity applied linear forecasts assuming that the rise in obesity would continue unabated. However, evi…
P. D. Mangan 🇺🇸Obesity and Severe Obesity Forecasts Through 2030
"The study estimates a 33% increase in obesity prevalence and a 130% increase in severe obesity prevalence over the next 2 decades." - from 2012
Even with assumption that trend is decelerating.
Part I : The Business Culture of Science Since 2000, there has been a 20-fold increase* in research funding for anti-aging medicine. Wow! That’s a good thing. But let’s keep our eyes on the ball. …
P. D. Mangan 🇺🇸Money in Aging Research, Part I
Some of the most potent anti-aging interventions aren't getting looked into properly because there's no money in them.
Diet, exercise, saunas, and fasting
Triglycerides cross the blood–brain barrier and induce central leptin and insulin receptor resistance
P. D. Mangan 🇺🇸Triglycerides cross the blood–brain barrier rapidly, are found in human cerebrospinal fluid, and induce central leptin and insulin receptor resistance, decreasing satiety and cognition.
Another good reason to keep triglycerides low.
Rats fed the genetically modified yeast-derived protein soy leghemoglobin – the burger’s key ingredient – developed unexplained weight gain and signs of toxicity. Report by Claire Robinson and Michael Antoniou, PhD
P. D. Mangan 🇺🇸Rat Feeding Study Suggests the Impossible Burger May Not Be Safe to Eat
Scientists found unusually high levels of one particular microbe in the guts of elite runners — and linked it to an energy source.
P. D. Mangan 🇺🇸Why are elite athletes different than the rest of us? Take a look at their microbes
Athletes had Veillonella, a lactate eating bug. Giving it to mice increased endurance performance 13%.
(2018). Omega-3 PUFAs and vitamin D co-supplementation as a safe-effective therapeutic approach for core symptoms of autism spectrum disorder: case report and literature review. Nutritional Neuroscience. Ahead of Print.
P. D. Mangan 🇺🇸Omega-3 PUFAs and vitamin D co-supplementation as a safe-effective therapeutic approach for core symptoms of autism spectrum disorder: case report and literature review
Dietary deficiency in polyunsaturated fatty acids (PUFA), including omega-3 fatty acids eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3), and excesses in omega-6 fatty acids including linoleic acid (LA, 18:2n-6) and...
P. D. Mangan 🇺🇸Bipolar disorder is associated with robust erythrocyte DHA [omega-3] deficits.
Shocker. Seems everywhere you look, either high o-6/3 ratio, or low o-3, is associated with worse mental health.
Background: The health benefits and risks of dietary supplement use are controversial. Objective: To evaluate the association among dietary supplement use, levels of nutrient intake from foods and supplements, and mortality among U.S. adults. ...
P. D. Mangan 🇺🇸Calcium supplements associated (once again) with increased death rate.
P. D. Mangan 🇺🇸Cardiovascular disease in Japan is only about 1/6 that of the U.S.
"differences cannot be explained by standard CVD risk factors, but may relate to marked population differences in levels of insulin and insulin resistance."
Not LDL, but insulin.
Repeated nucleotide sequences combined with proteins called telomeres cover chromosome ends and dictate cells lifespan. Many factors can modify telomere length, among them are: nutrition and smoking habits, physical activities and socioeconomic...
P. D. Mangan 🇺🇸Red meat consumption associated with increased telomere length.
Meaning, on average, red meat eaters can expect to live longer.
"may undermine some accepted concepts of adverse effects of this diet on the health status and life longevity."