JT McCrone
Postdoctoral researcher at the University of Edinburgh. I study how virus evolution can inform interventions during outbreaks.
Thought Leader
| #346 | Infectious Disease |
Last synced from Twitter 90d ago
Phyloseminar #99: Emma Hodcroft (Biozentrum University of Basel)
Real time tracking for real-life pandemics: Nextstrain and SARS-CoV-2 The emergence of SARS-CoV-2 has driven an enormous global effort to contribute and shar...
Establishment & lineage dynamics of the SARS-CoV-2 epidemic in the UK
The UK's COVID-19 epidemic during early 2020 was one of world's largest and unusually well represented by virus genomic sampling. Here we reveal the fine-scale genetic lineage structure of this epidemic through analysis of 50,887 SARS-CoV-2 genomes,...
Virus rebel Professor Edward Holmes named NSW Scientist of the Year
The man who first published the genome sequence of the coronavirus for the world to see has been named NSW Scientist of the Year.
MAJORA: Continuous integration supporting decentralised sequencing for SARS-CoV-2 genomic surveillance
Genomic epidemiology has become an increasingly common tool for epidemic response. Recent technological advances have made it possible to sequence genomes rapidly enough to inform outbreak response, and cheaply enough to justify dense sampling of...
Reassortment networks and why I think they’re cool
Why you’re reading this
Bayesian inference of reassortment networks reveals fitness benefits of reassortment in human influenza viruses
Genetic recombination processes, such as reassortment, make it complex or impossible to use standard phylogenetic and phylodynamic methods. This is due to the fact that the shared evolutionary history of individuals has to be represented by a...
ESCMID: Practical Workshops
ESCMID - European Society of Clinical Microbiology and Infectious Diseases 2008
Spinal muscular atrophy — challenges in the therapeutic era
With the advent of disease-modifying therapies for spinal muscular atrophy, prenatal and extra-neural alterations associated with the condition have garnered increasing attention as potential determinants of the therapeutic window and efficacy of...
Clostridioides difficile: Sometimes It Pays To Be Difficult
In this issue of Cell Host & Microbe, publications from Bushman et al. (2020) and
Knippel et al. (2020) outline elements of host epithelial damage or inflammation that
Clostridioides difficile subverts, enabling continued growth. These mechanisms...
40 Under 40: The Most Influential Young People in Business 2017
Read on to meet these disruptors, innovators, rebels and artists—and prepare to be inspired.
nCoV-2019 sequencing protocol v3 (LoCost)
Amplicon sequencing protocol for SARS-CoV-2 v3 (LoCost)We thank the ARTIC network, Oxford Nanopore Technologies, New England Biolabs, BCCDC, COG-UK, CanCOGen and protocols.io commenters...
The early evolution of oral poliovirus vaccine is shaped by strong positive selection and tight transmission bottlenecks
The evolution of circulating vaccine-derived polioviruses (cVDPV) from components of the live-attenuated oral poliovirus vaccine (OPV) presents a major challenge to global polio eradication. This process has largely been characterized by consensus...
Evidence of significant natural selection in the evolution of SARS-CoV-2 in bats, not humans
RNA viruses are proficient at switching to novel host species due to their fast mutation rates. Implicit in this assumption is the need to evolve adaptations in the new host species to exploit their cells efficiently. However, SARS-CoV-2 has...
A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology
The authors propose a nomenclature of SARS-CoV-2 lineages to assist research on epidemiology and decision-making during the COVID-19 pandemic. This nomenclature is based on the SARS-CoV-2 phylogeny and designed to provide a real-time bird’s-eye view...
Using mutations to track the pandemic coronavirus
Research Lives: Áine O’Toole, PhD student at University of Edinburgh