New guidelines from he American Society of Hematology for treating newly diagnosed acute myeloid leukemia in older patients recommend intensive antileukemic therapies over more conservative approaches.
After months of caving to pressures from the White House, Commissioner Stephen Hahn and a band of agency scientists have eked out a few victories.
Mikkael Sekeres MD“Dr. Hahn seems to be trying to save the FDA from the fate of its sister agency, the Centers for Disease Control and Prevention, whose scientists have been stripped of their authority and independence in responding to the pandemic.” Better late than never.
An antiviral widely used to treat hospitalized patients did not lower the mortality rate in a multinational trial.
Mikkael Sekeres MD“The study’s authors called the findings “unpromising” and said they “suffice to refute early hopes” that [remdesivir] “will substantially reduce inpatient mortality, initiation of ventilation or hospitalization duration.” Sigh. This in 11,000 patients. ☹️
The pressure on his top administration officials to take action came as President Trump bristled at the restraints of his illness.
Mikkael Sekeres MD“Senator Mitch McConnell of Kentucky, the majority leader, even indicated that he was boycotting the White House because of its lax handling of the virus.” As if that doesn’t say worlds!
Editorial from The New England Journal of Medicine — Dying in a Leadership Vacuum
Mikkael Sekeres MD“Our leaders have undercut trust in science and in government, causing damage that will outlast them. Instead of relying on expertise, the administration has turned to charlatans who obscure the truth and facilitate the promulgation of outright lies.”
The infections were a byproduct, former aides said, of the recklessness and top-down culture of fear that President Trump created at the White House and throughout his administration.
Mikkael Sekeres MD“Almost no one wore masks. The rare officials who did were ridiculed by colleagues as alarmists. Everyone knew that Mr. Trump viewed masks as a sign of weakness.” Workplace harassment defined, that jeopardized people’s health.
He disparaged masks, encouraged big campaign crowds and employed an often-unreliable test to keep him safe. All the while it turned out the virus was nearby.
Mikkael Sekeres MDRead this roadmap of reckless behavior in spread of #COVID19 within @WhiteHouse inner circle: use of Covid test with 33% false negative rate, disregard for masks while indoors keys to transmission!
The president’s result came after he spent months playing down the severity of the outbreak that has killed more than 207,000 in the United States and hours after insisting that “the end of the pandemic is in sight.”
Mikkael Sekeres MDWow...speechless. Please wear masks everyone. Protect others and yourselves. Protect my patients.
Editorial from The New England Journal of Medicine — The FDA and the Importance of Trust
Mikkael Sekeres MD“Today more than ever, as science is being manipulated and disregarded, it is critical that the FDA uphold its standards and objectivity. Truth may be difficult to know, but the scientific process is our best path to knowing it.” This for #COVID19 vaccines
Unfolding in a stable presidential race and a tumultuous election year, the debate may be less likely than past ones to sway voters. But it is still an opportunity for President Trump in particular.
Mikkael Sekeres MDInteresting how @JoeBiden uses empathy to connect with voters suffering from #COVID19 and other losses, reflecting on his own family’s tragic losses. #Cancer doctors and nurses do the same with our patients! 😢 💙😢💙
Long lines of mourners waited outside the Supreme Court to pay their respects, but President Trump again made clear he would not honor her dying wish that filling her seat wait until the next president was chosen.
Mikkael Sekeres MD“What is the difference between a bookkeeper in Brooklyn and a Supreme Court justice? One generation.” I miss RBG 😢
The agency now says anyone exposed to an infected person for more than 15 minutes needs a test. An earlier guideline saying it might not be necessary had shocked public health experts.
Mikkael Sekeres MD“Current science shows that testing people who have been in close contact with someone with #Covid19 is an important part of preventing disease transmission.” We will recover from the pandemic. But will @CDCgov recover its credibility?