Perspective from The New England Journal of Medicine — Reforming the Orphan Drug Act for the 21st Century
NEJMPerspective: Reforming the Orphan Drug Act for the 21st Century
NEJMPerspective: In recent years, several manufacturers have earned hundreds of millions of dollars in annual revenue from rare-disease drugs. Such cases raise the question of whether the Orphan Drug Act should be reformed to better align with patients’ needs.
Clinical Practice from The New England Journal of Medicine — Measles
NEJMClinicians should suspect #measles in persons with a febrile rash illness, especially if they lack documentation of measles vaccination, have recently traveled overseas, or are part of a community with low vaccine acceptance. Read more
Original Article from The New England Journal of Medicine — C-Reactive Protein Testing to Guide Antibiotic Prescribing for COPD Exacerbations
NEJMIn this randomized trial, C-reactive protein testing was used as a point-of-care aid in determining whether antibiotic therapy was warranted in patients with an acute exacerbation of COPD. See the results
NEJMOriginal Article: C-Reactive Protein Testing to Guide Antibiotic Prescribing for COPD Exacerbations
Original Article from The New England Journal of Medicine — A Multicenter Trial of Vena Cava Filters in Severely Injured Patients
NEJMEarly prophylactic placement of a vena cava filter after major trauma does not result in a lower incidence of symptomatic pulmonary embolism or death at 90 days than no placement of a filter. #ISTH2019 nej.md/2Xm9uHmpic.twitter.com/7jXvYAW5hx
Perspective from The New England Journal of Medicine — Imaging an Outbreak — Ultrasound in an Ebola Treatment Unit
NEJMPerspective: Facing varied, often baffling, manifestations of Ebola virus disease and lacking on-site diagnostic capacity, the author began using point-of-care ultrasonography. Learn more: nej.md/2JipuFvpic.twitter.com/sphSBqgSht
Perspective from The New England Journal of Medicine — Serious-Illness Care 2.0 — Meeting the Needs of Patients with Heart Failure
NEJMPerspective: Heart failure is the most common cause of hospitalizations among elderly Americans, and despite much medical and scientific progress, it remains a source of substantial suffering, expense, and caregiver burden. Read more
Original Article from The New England Journal of Medicine — Application of High-Sensitivity Troponin in Suspected Myocardial Infarction
NEJMData regarding high-sensitivity troponin concentrations in patients presenting to the emergency department with symptoms suggestive of myocardial infarction may be useful in determining the probability of myocardial infarction and subsequent outcomes.
NEJMA 17-year-old boy presented to the ED with pain and swelling in his jaw 2 hours after an e-cigarette exploded during use. He had extensive lacerations in his mouth, multiple disrupted lower incisors, and bony incongruity of his left mandible.