Nature Neuroscience
News, commentary and research coverage from the international monthly journal publishing the highest quality of work in all areas of neuroscience.
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The intrinsic attractor manifold and population dynamics of a canonical cognitive circuit across waking and sleep
Nature Neuroscience 6d 4 tweets
Neural populations often encode unknown variables. Chaudhuri et al. develop a method to decode unknown variables by finding shapes in neural data. They show that a mammalian brain circuit of thousands of neurons constructs a navigational compass...
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Nature Neuroscience A method to decode unknown variables by finding shapes in neural data shows the existence of a low-dimensional #manifold that forms a continuous ring of stable states in mouse head direction neurons 6d
Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid
Nature 25d 8 tweets
Clearance of macromolecules from the cerebrospinal fluid in mice takes place via meningeal lymphatic vessels at the base of the skull; both drainage and the integrity of these vessels deteriorate with age.
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Nature Neuroscience Check out this paper on meningeal lymphatic vessels just published in 24d
A neural heading estimate is compared with an internal goal to guide oriented navigation
Nature Neuroscience 27d 2 tweets
Green et al. find that, when their internal heading estimate is rotated via neural stimulation, flies turn their body in a direction that aims to return their heading estimate back to its previous value. This suggests the heading estimate is...
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Nature Neuroscience When their internal heading estimate is rotated via neural stimulation, flies turn their body to return their estimate back to its previous value, suggesting that the estimate is compared with an internal goal to guide navigation 24d
Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice
Nature Neuroscience 27d 1 tweets
Guo et al. show that synaptic alterations in ACC pyramidal neurons underlie social impairments in Shank3 mutant mice and that selective activation of ACC pyramidal neurons or enhancing AMPAR function improves social behavior in these mice.
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Nature Neuroscience Synaptic alterations in anterior cingulate cortex (ACC) neurons underlie social impairments in mice with mutated Shank3, a high-confidence #autism gene 27d
Functional boundaries in the human cerebellum revealed by a multi-domain task battery
Nature Neuroscience 38d 5 tweets
Using a large task battery spanning motor, cognitive, social and affective domains, this functional MRI (fMRI) study provides a comprehensive functional map of the human cerebellum, along with a comparison to maps derived from anatomy and...
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Nature Neuroscience Functional boundaries in the human #cerebellum revealed by having participants perform 26 tasks spanning motor, cognitive, social, and affective domains during #fMRI 37d
Parietal neurons encode information sampling based on decision uncertainty
Nature Neuroscience 38d 2 tweets
Parietal neurons encode the information gains that saccades are expected to bring for subsequent actions independently of economic utility, consistent with a boost in neural gain to facilitate the implementation of sampling policies.
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Nature Neuroscience Parietal neurons encode information sampling based on decision uncertainty 38d
A whole-brain map of long-range inputs to GABAergic interneurons in the mouse medial prefrontal cortex
Nature Neuroscience 39d 1 tweets
Sun et al. built a comprehensive atlas of inputs to major types of GABAergic interneurons in the prefrontal cortex of mice. Through three-dimensional reconstruction of neural morphology, the authors classified input neurons and identified novel...
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Nature Neuroscience A whole-brain atlas of direct long range inputs to GABAergic #interneurons in the medial #prefrontal cortex (mPFC) of male mice 39d
A diversity of interneurons and Hebbian plasticity facilitate rapid compressible learning in the hippocampus
Nature Neuroscience 55d 2 tweets
How does the hippocampus learn with only a single presentation of a stimulus? Nicola and Clopath show how interneuron networks can dilate pre-existing spike sequences during sharp waves into theta sequences for one-shot learning.
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Nature Neuroscience #Interneuron networks serve as the scaffolding for one-shot learning by replaying, reversing, refining, and regulating spike sequences 53d
Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability
Nature Neuroscience 62d 4 tweets
The authors show that decreased synaptic efficacy onto raphe-projecting lateral habenula neurons supports opiate withdrawal-induced sociability deficits, and they demonstrate a role for TNF-α signaling in this process.
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Nature Neuroscience . and colleagues show that morphine withdrawal recruits lateral habenula TNFα signaling to reduce synaptic excitation and sociability 58d
Optodbs
Optodbs.ch 787d 13 tweets
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Nature Neuroscience Nature Neuroscience editor Luis Mejia will be at the OptoDBS meeting in Switzerland this week! #OptoDBS #OptoDBS2019 #OptoDBS19 60d
Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling
Nature Neuroscience 62d 4 tweets
Microglia are resident immune cells of the CNS. Here the authors show that neurons communicate to microglia via activity-dependent fractalkine and ADAM10 signaling to induce removal of synapses in the brain after sensory loss.
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Nature Neuroscience Neurons communicate to #microglia via activity-dependent fractalkine and ADAM10 signaling to induce removal of cortical synapses after loss of sensory input 60d
Classification of electrophysiological and morphological neuron types in the mouse visual cortex
Nature Neuroscience 62d 3 tweets
Gouwens et al. established a morpho-electrical taxonomy of cell types for the mouse visual cortex via unsupervised clustering analysis of multiple quantitative features from 1,938 neurons available online at the Allen Cell Types Database.
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Nature Neuroscience A taxonomy of cell types in the mouse visual cortex via unsupervised clustering analysis of multiple morphological and electrophysiological features from 61d
Divergence in the functional organization of human and macaque auditory cortex revealed by fMRI responses to harmonic tones
Nature Neuroscience 69d 2 tweets
Norman-Haignere et al. report that humans but not macaque monkeys possess cortical regions with a strong preference for harmonic tones compared to noise. This species difference may be driven by the demands of speech and music perception in humans.
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Nature Neuroscience Humans (but not macaques) have cortical regions with a strong preference for harmonic tones compared to noise, perhaps due to the human brain's needs for processing speech and music 🎶 68d
Single-cell activity tracking reveals that orbitofrontal neurons acquire and maintain a long-term memory to guide behavioral adaptation
Nature Neuroscience 76d 4 tweets
Namboodiri, Otis et al. reveal that orbitofrontal cortex acquires and maintains a long-term memory of cue–reward associations to guide multiple aspects of behavioral learning, and that it routes select information to a downstream learning center.
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Nature Neuroscience . and colleagues show that #orbitofrontal cortex (OFC) neurons acquire and maintain a long-term memory of cue-reward associations to guide multiple aspects of behavior 74d
Volume 22 Issue 6, June 2019
Nature.com 86d 1 tweets
Volume 22 Issue 6, June 2019
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Nature Neuroscience Our June issue, featuring some adorable macrophages, is now live! 86d
Effective learning is accompanied by high-dimensional and efficient representations of neural activity
Nature Neuroscience 89d 3 tweets
Why do certain individuals learn faster than others, and how does the acquired information take shape within their brains? Tang and colleagues show that fast learners encode information in a particularly compact, efficient and space-saving manner.
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Nature Neuroscience Analysis of fMRI data from and colleagues shows that fast learners encode information in a particularly compact, efficient, and space-saving manner 89d
Compulsivity and impulsivity traits linked to attenuated developmental frontostriatal myelination trajectories
Nature Neuroscience 97d 3 tweets
Ziegler, Hauser et al. report brain-wide, myelin-related microstructural growth from adolescence to adulthood and show that this longitudinal growth is reduced in the presence of compulsivity and impulsivity traits.
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Nature Neuroscience Magnetization transfer (MT) MRI shows that brain-wide, #myelin-related microstructure grows from adolescence to adulthood, and this growth is reduced in the presence of compulsivity and impulsivity traits 97d
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment
Nature Neuroscience 104d 3 tweets
Van Hove et al. reveal the diversity of macrophages at the brain’s border regions via single-cell analysis and fate-mapping. This also identified a microglial subset at the surface of the choroid plexus, in direct contact with cerebrospinal fluid.
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Nature Neuroscience The diversity of brain #macrophages, including border-associated macrophages (BAMs) from the dura mater, subdural meninges, and choroid plexus, revealed with single-cell RNA sequencing, high-dimensional cytometry, and fate-mapping 103d
A novel cortico-intrathalamic circuit for flight behavior
Nature Neuroscience 107d 1 tweets
Dong, Wang et al. uncover a circuit linking Glu+cingulate inputs→PV+ neurons in the limbic thalamic reticular nucleus→intermediodorsal thalamic nucleus, and show that this cortico-intrathalamic circuit is a component of the fear circuitry and...
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Nature Neuroscience A corticothalamic circuit through the thalamic reticular nucleus (TRN) that controls flight in response to fear 107d
Evidence that recurrent circuits are critical to the ventral stream’s execution of core object recognition behavior
Nature Neuroscience 111d 2 tweets
Using model- and primate behavior-driven image selection with large-scale electrophysiology in monkeys performing core recognition tasks, Kar et al. provide evidence that automatically engaged recurrent circuits are critical for rapid object...
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Nature Neuroscience Recurrent circuits in the primate ventral stream are critical for rapid object identification 109d