Nature Neuroscience
News, commentary and research coverage from the international monthly journal publishing the highest quality of work in all areas of neuroscience.
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Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits
Nature Neuroscience 25h 3 tweets
A genetic study of problematic alcohol use in 435,563 individuals, including data from the Million Veteran Program, Psychiatric Genomics Consortium and UK Biobank, found many novel risk loci and provided new insights into trait biology.
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Nature Neuroscience Genome-wide meta-analysis (#GWAS) of problematic alcohol use in 435,563 individuals, including data from the US Million Veterans Program, , and 8h
Assessing the depth of language processing in patients with disorders of consciousness
Nature Neuroscience 53h 2 tweets
Assessing residual consciousness in unresponsive patients is a major clinical concern. Gui et al. demonstrate that EEG-based language assessment can objectively characterize states of consciousness and predict outcomes in individual patients.
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Nature Neuroscience #EEG-based language assessment can objectively characterize and predict states of #consciousness, and longitudinally track individual patients’ language processing abilities at the bedside 30h
General anesthetics activate a potent central pain-suppression circuit in the amygdala
Nature Neuroscience 9d 5 tweets
Hua and Chen et al. show that general anesthesia activates a distinct population of central amygdala neurons and that these neurons can potently suppress pain responses through their widespread projections to many pain-processing centers in the...
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Nature Neuroscience General #anesthetics activate a potent pain-suppression circuit in the central #amygdala 5d
The claustrum coordinates cortical slow-wave activity
Nature Neuroscience 16d 2 tweets
The authors establish the claustrum-Cre transgenic mouse line and demonstrate that the claustrum orchestrates cortical slow-wave activity by synchronously driving the inhibitory interneurons in widespread cortical areas.
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Nature Neuroscience The #claustrum coordinates cortical slow-wave activity 16d
Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction
Nature Neuroscience 23d 1 tweets
Marshall et al. show that regions of the genome adopt a noncanonical Z-DNA state in the prefrontal cortex in response to fear learning and that binding of Adar1 reduces Z-DNA during extinction learning, which is required for memory flexibility.
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Nature Neuroscience . and colleagues show that dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction 23d
Within-group synchronization in the prefrontal cortex associates with intergroup conflict
Nature Neuroscience 29d 3 tweets
Using fNIRS hyperscanning in three-versus-three-person intergroup competitions, this study shows that in-group bonding and within-group synchronization of reduced dorsolateral prefrontal activity escalate intergroup conflict.
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Nature Neuroscience Within-group neural synchronization in the right dorsolateral prefrontal cortex (rDLPFC) and the right temporoparietal junction (rTPJ) as a candidate mechanism underlying intergroup hostility 29d
Disease-associated astrocytes in Alzheimer’s disease and aging
Nature Neuroscience 30d 2 tweets
A new subset of disease-associated astrocytes (DAAs) is identified in a mouse model of Alzheimer’s disease by single-nucleus RNA sequencing. DAAs are also found in aged wild-type mice, suggesting a link to genetic and age-related factors.
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Nature Neuroscience Disease-associated #astrocytes revealed using single-nucleus RNA sequencing in an #Alzheimer’s disease mouse model; they increased with disease progression and could also bee seen in aged mouse and human brains 30d
Ronald S. Duman, PhD (1954–2020)
Nature Neuroscience 35d 2 tweets
Ronald S. Duman, the Elizabeth Mears and House Jameson Professor of Psychiatry, Professor of Neuroscience at the Yale University School of Medicine and Director of the Abraham Ribicoff Research Facilities of the Connecticut Mental Health Center,...
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Nature Neuroscience Please read our remembrance of Ron Duman from his colleagues in , Marina Picciotto (), Jane Taylor, and Ralph DiLeone 35d
Primate auditory prototype in the evolution of the arcuate fasciculus
Nature Neuroscience 37d 3 tweets
Balezeau et al. find a primate homolog of the human language pathway within the auditory system of monkeys and apes. This discovery pushes back the human language pathway’s origin by about 20 million years and illuminates its remarkable evolutionary...
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Nature Neuroscience Identification in monkeys and chimps of an evolutionary prototype of the arcuate fasciculus pathway, which is crucial for language in humans, using auditory functional fields and diffusion-weighted MRI 36d
Associative and plastic thalamic signaling to the lateral amygdala controls fear behavior
Nature Neuroscience 37d 1 tweets
The authors describe a thalamic population, innervated by multimodal brainstem inputs, that forms a CS–US association prior to the lateral amygdala. Its fast and plastic signal defines an amygdala activity pattern necessary for adaptive fear...
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Nature Neuroscience Lateral #thalamus neurons that express calretinin provide integrated CS–US representations to the lateral #amygdala (LA) that support the formation of aversive memories in mice 37d
Four core properties of the human brain valuation system demonstrated in intracranial signals
Nature Neuroscience 42d 3 tweets
Lopez-Persem et al. used intracranial recordings in people with epilepsy to uncover key functional properties of neural value signals that might explain irrational choice behavior.
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Nature Neuroscience Key functional properties of neural value signals (anticipation, generality, automaticity, quadraticity) revealed using intracranial electroencephalography in humans with epilepsy 42d
Deconstructing the neurobiology of cannabis use disorder
Nature Neuroscience 51d 2 tweets
The increasing use of cannabis has brought significant attention to cannabis use disorder (CUD) and its neurobiological underpinnings. Here Ferland and Hurd discuss risk factors related to the development of CUD its neurobiological characteristics.
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Nature Neuroscience A review from Yasmin Hurd () on the neurobiology of #cannabis use disorder 50d
Hippocampal neurons represent events as transferable units of experience
Nature Neuroscience 51d 9 tweets
Hippocampal neurons track events as abstract units of episodic experience. These event representations can be transferred between different experiences and are separately manipulable from hippocampal representations of continuous changes in space.
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Nature Neuroscience Neurons in the CA1 region of the #hippocampus encode events as discrete and transferable units of experience 51d
Translating the brain
Nature Neuroscience 58d 1 tweets
A new study shows that mapping neural signals directly to word sequences produces lower error rates in speech decoding than previous methods that use motor or auditory based features. This suggests that using higher-level language goals can aid...
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Nature Neuroscience Also check out the News & Views by : 58d
Machine translation of cortical activity to text with an encoder–decoder framework
Nature Neuroscience 58d 8 tweets
Makin and colleagues decode speech from neural signals recorded during a preoperative procedure, using an algorithm inspired by machine translation. For one participant reading from a closed set of 50 sentences, decoding accuracy is nearly perfect.
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Nature Neuroscience Makin, Moses, and Chang at used an algorithm inspired by machine translation to decode speech from recorded neural activity, and obtained nearly perfect decoding accuracy for one participant. 58d
In memory of Bruce McEwen: a gentle giant of neuroscience
Nature Neuroscience 65d 5 tweets
On 2 January 2020, the neuroscience community lost not only a pioneering figure, but also a generous and influential thought leader. Bruce Sherman McEwen, head of the Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology at the...
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Nature Neuroscience Please read our remembrance of Bruce McEwen 64d
Personal space regulation by the human amygdala
Nature Neuroscience 73d 3 tweets
The amygdala is critical for processing information about emotion, but little is known about what role it might play in human behavioral interactions. Here the authors report that a patient with complete bilateral amydala lesions lacks any sense of...
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Nature Neuroscience While practicing social distancing, remember to be thankful for your #amygdala! 71d
Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk
Nature Neuroscience 71d 2 tweets
Jaffe et al. profile the granule cell layer of the human hippocampus and find unique molecular associations for aging and genetic variation, as well as diagnosis with schizophrenia and its genetic risk, that were previously undiscovered in...
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Nature Neuroscience #Transcriptomic profiling of dentate gyrus granule cells from the human #hippocampus reveals widespread cell-type-enriched aging and #eQTL effects that were either absent or directionally discordant in bulk hippocampus data 71d
A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles
Nature Neuroscience 79d 2 tweets
Sey et al. report a computational tool, H-MAGMA, that extracts neurobiological insights from brain-disorder GWAS by linking risk variants to their cognate genes using chromatin interaction profiles from human brain tissue.
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Nature Neuroscience A computational tool (#H-MAGMA) for improved prediction of brain-disorder risk genes from #GWAS data by incorporating brain chromatin interaction profiles 79d
Dysfunction of cortical GABAergic neurons leads to sensory hyper-reactivity in a Shank3 mouse model of ASD
Nature Neuroscience 84d 2 tweets
Chen, Deister et al. show that Shank3B-knockout mice display hypersensitivity to tactile sensory stimulation and that dysfunction of interneurons in somatosensory cortex contributes to the sensory hyper-reactivity in this mouse model of autism.
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Nature Neuroscience Hyper-reactivity to touch in a Shank3 mouse model of #autism is related to dysfunction of GABAergic neurons in somatosensory cortex 84d