Nature Neuroscience
News, commentary and research coverage from the international monthly journal publishing the highest quality of work in all areas of neuroscience.
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Challenges and future directions for representations of functional brain organization
Nature Neuroscience 90d 5 tweets
In this Primer article, Bijsterbosch and colleagues provide an accessible discussion of the challenges faced in analytical representations of functional brain organization and provide clear recommendations to unite a fractionated field.
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Nature Neuroscience A review on challenges and future directions for representations of functional brain organization from , , , , , Sam Harrison, and Mark Woolrich 89d
Volume 23 Issue 11, November 2020
Nature.com 92d 3 tweets
Volume 23 Issue 11, November 2020
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Nature Neuroscience Our November issue is now online! 90d
Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia
Nature Neuroscience 90d 1 tweets
When co-cultured with activated microglia, iPSC-derived interneurons from individuals with schizophrenia and from healthy controls show defects in metabolic pathways, but only the interneurons from individuals with schizophrenia showed prolonged...
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Nature Neuroscience Activated #microglia disrupt mitochondrial function in #iPSC-derived developing cortical #interneurons that persist in interneurons from individuals with #schizophrenia 90d
Edge-centric functional network representations of human cerebral cortex reveal overlapping system-level architecture
Nature Neuroscience 97d 6 tweets
The authors present an edge-centric model of brain connectivity. Edge networks are stable across datasets, and their structure can be modulated by sensory input. When clustered, edge networks yield pervasively overlapping functional modules.
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Nature Neuroscience Network neuroscience has focused on nodes to represent brain regions, neurons, etc., and edges as interactions among them. & present a new framework to examine edge functional connectivity. 95d
Neural mechanisms of aggression across species
Nature Neuroscience 103d 2 tweets
Aggression is an instinctive behavior supported by hardwired neural circuits. Julieta Lischinsky and Dayu Lin review our current understanding of the neural circuits of aggression across species and their modulation by internal state.
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Nature Neuroscience A review on the neural circuits regulating #aggression across species, and their modulation by internal state, from and 103d
Circuit and molecular architecture of a ventral hippocampal network
Nature Neuroscience 132d 4 tweets
The ventral hippocampus is central in the processing of emotional information. Here, a combination of viral and sequencing approaches defines the organizational logic of the extended ventral CA1 circuit.
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Nature Neuroscience Circuit and molecular architecture of a ventral hippocampal network 128d
Dense neuronal reconstruction through X-ray holographic nano-tomography
Nature Neuroscience 132d 4 tweets
Kuan, Phelps, et al. used synchrotron X-ray imaging and deep learning to map dense neuronal wiring in fly and mouse tissue, enabling examination of individual cells and connectivity in circuits governing motor control and perceptual decision-making.
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Nature Neuroscience , Lee and colleagues show that X-ray holographic nano-tomography can image millimeter-scale volumes with sub-100-nm resolution 131d
Climbing fiber synapses rapidly and transiently inhibit neighboring Purkinje cells via ephaptic coupling
Nature Neuroscience 139d 2 tweets
Han et al. find that, in addition to powerfully exciting Purkinje cells, climbing fibers rapidly suppress firing in nearby Purkinje cells. Current from glutamate receptor activation generates large extracellular signals that inhibit neighboring...
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Nature Neuroscience Climbing fibers rapidly and transiently suppress neighboring Purkinje cells through ephaptic coupling 135d
A community-based transcriptomics classification and nomenclature of neocortical cell types
Nature Neuroscience 153d 5 tweets
To understand the function of cortical circuits, it is necessary to catalog their cellular diversity. Past attempts to do so using anatomical, physiological or molecular features of cortical cells have not resulted in a unified taxonomy of neuronal...
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Nature Neuroscience A group of researchers proposes a standardized classification and nomenclature of cell types in the cortex based on single-cell #transcriptomics 151d
Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans
Nature Neuroscience 160d 5 tweets
This study describes a series of new gene-regulatory sequences that restrict expression of viral transgenes to specific interneuron subtypes, allowing for selective monitoring and manipulation of their activity from mice to humans.
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Nature Neuroscience Viruses for interneuron subtype-specific expression of transgenes in rodents and primates 158d
Goal-directed actions transiently depend on dorsal hippocampus
Nature Neuroscience 167d 5 tweets
This study shows that the dorsal hippocampus is necessary for goal-directed action, but only transiently, during initial learning. Convergently, goal-directed actions also depend transiently on the physical context.
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Nature Neuroscience Dorsal hippocampus is necessary for goal-directed action but only transiently during initial learning 165d
A quantitative reward prediction error signal in the ventral pallidum
Nature Neuroscience 167d 3 tweets
The nervous system is hypothesized to calculate reward prediction errors to estimate reward availability in the environment. The authors quantify a robust prediction error signal in the ventral pallidum derived from recently received rewarding...
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Nature Neuroscience . find a robust prediction error signal in the ventral pallidum derived from recently received rewarding outcomes 166d
Starring role for astrocytes in memory
Nature Neuroscience 170d 1 tweets
Following learning, memories for events are reorganized in a time-dependent manner in distributed hippocampal–cortical networks. While previous studies have focused on neural contributions to this process of systems consolidation, a new study by Kol...
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Nature Neuroscience And check out the News and Views from and ! 170d
High-fat food biases hypothalamic and mesolimbic expression of consummatory drives
Nature Neuroscience 174d 4 tweets
Mazzone and Liang-Guallpa et al. demonstrate that consuming high-fat foods rapidly and durably tunes parallel brain circuits to drive intake of a high-fat diet while devaluing a nutritionally balanced, standard diet even under states of intense...
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Nature Neuroscience High-fat food biases #hypothalamic and #mesolimbic expression of consummatory drive 172d
Active dendritic currents gate descending cortical outputs in perception
Nature Neuroscience 174d 7 tweets
The authors showed that the ‘moment of perception’ is causally related to dendritic activity in subcortically projecting layer 5 pyramidal neurons that project to the higher-order thalamus, superior colliculus and striatum.
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Nature Neuroscience Active #dendritic currents gate descending cortical outputs in #perception 173d
Posterior amygdala regulates sexual and aggressive behaviors in male mice
Nature Neuroscience 181d 6 tweets
Yamaguchi et al. identify a little-known amygdalar region, the posterior amygdala, as a key node in male mouse social behaviors. Two largely non-overlapping subpopulations in the posterior amygdala form parallel projections to distinct hypothalamic...
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Nature Neuroscience Posterior #amygdala regulates sexual and aggressive behaviors in male mice. New from and colleagues. 177d
Volume 23 Issue 8, August 2020
Nature.com 180d 1 tweets
Volume 23 Issue 8, August 2020
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Nature Neuroscience Our August issue is now live! 180d
Complementary contributions of non-REM and REM sleep to visual learning
Nature Neuroscience 187d 6 tweets
Tamaki et al. measured MRS changes in sleeping humans trained on a visual task. During NREM sleep, learning gains were associated with enhanced visual cortical plasticity that was also seen independent of learning. REM sleep stabilized plasticity...
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Nature Neuroscience Tamaki, Sasaki and colleagues find that E/I balance changes from NREM to REM #sleep. This change can be modulated by learning. 186d
SPARC enables genetic manipulation of precise proportions of cells
Nature Neuroscience 188d 1 tweets
SPARC is an all-genetic toolkit to express effectors in precise proportions of neurons. This method enables imaging of individual neurons and manipulation of neuronal subpopulations.
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Nature Neuroscience The Clandinin group describes a novel method, called SPARC, for targeting effector proteins to precise populations of cells 188d
Microglia phagocytose myelin sheaths to modify developmental myelination
Nature Neuroscience 202d 3 tweets
Microglia refine the developing CNS by engulfing excess neurons and synapses. Hughes and Appel here show that microglia also prune myelin sheaths in a neuronal activity-regulated manner to sculpt developmental myelination.
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Nature Neuroscience . and find that #microglia not only prune synapses and neurons but #myelin sheaths as well . 200d