Nature Neuroscience
News, commentary and research coverage from the international monthly journal publishing the highest quality of work in all areas of neuroscience.
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Nature Neuroscience Nature Neuroscience editor Luis Mejia will be at the OptoDBS meeting in Switzerland this week! #OptoDBS #OptoDBS2019 #OptoDBS19 28h
Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling
Nature Neuroscience 3d 4 tweets
Microglia are resident immune cells of the CNS. Here the authors show that neurons communicate to microglia via activity-dependent fractalkine and ADAM10 signaling to induce removal of synapses in the brain after sensory loss.
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Nature Neuroscience Neurons communicate to #microglia via activity-dependent fractalkine and ADAM10 signaling to induce removal of cortical synapses after loss of sensory input 34h
Classification of electrophysiological and morphological neuron types in the mouse visual cortex
Nature Neuroscience 3d 3 tweets
Gouwens et al. established a morpho-electrical taxonomy of cell types for the mouse visual cortex via unsupervised clustering analysis of multiple quantitative features from 1,938 neurons available online at the Allen Cell Types Database.
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Nature Neuroscience A taxonomy of cell types in the mouse visual cortex via unsupervised clustering analysis of multiple morphological and electrophysiological features from 58h
Divergence in the functional organization of human and macaque auditory cortex revealed by fMRI responses to harmonic tones
Nature Neuroscience 10d 2 tweets
Norman-Haignere et al. report that humans but not macaque monkeys possess cortical regions with a strong preference for harmonic tones compared to noise. This species difference may be driven by the demands of speech and music perception in humans.
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Nature Neuroscience Humans (but not macaques) have cortical regions with a strong preference for harmonic tones compared to noise, perhaps due to the human brain's needs for processing speech and music 🎶 9d
Single-cell activity tracking reveals that orbitofrontal neurons acquire and maintain a long-term memory to guide behavioral adaptation
Nature Neuroscience 17d 4 tweets
Namboodiri, Otis et al. reveal that orbitofrontal cortex acquires and maintains a long-term memory of cue–reward associations to guide multiple aspects of behavioral learning, and that it routes select information to a downstream learning center.
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Nature Neuroscience . and colleagues show that #orbitofrontal cortex (OFC) neurons acquire and maintain a long-term memory of cue-reward associations to guide multiple aspects of behavior 15d
Volume 22 Issue 6, June 2019
Nature.com 27d 1 tweets
Volume 22 Issue 6, June 2019
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Nature Neuroscience Our June issue, featuring some adorable macrophages, is now live! 27d
Effective learning is accompanied by high-dimensional and efficient representations of neural activity
Nature Neuroscience 30d 3 tweets
Why do certain individuals learn faster than others, and how does the acquired information take shape within their brains? Tang and colleagues show that fast learners encode information in a particularly compact, efficient and space-saving manner.
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Nature Neuroscience Analysis of fMRI data from and colleagues shows that fast learners encode information in a particularly compact, efficient, and space-saving manner 30d
Compulsivity and impulsivity traits linked to attenuated developmental frontostriatal myelination trajectories
Nature Neuroscience 38d 2 tweets
Ziegler, Hauser et al. report brain-wide, myelin-related microstructural growth from adolescence to adulthood and show that this longitudinal growth is reduced in the presence of compulsivity and impulsivity traits.
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Nature Neuroscience Magnetization transfer (MT) MRI shows that brain-wide, #myelin-related microstructure grows from adolescence to adulthood, and this growth is reduced in the presence of compulsivity and impulsivity traits 38d
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment
Nature Neuroscience 45d 3 tweets
Van Hove et al. reveal the diversity of macrophages at the brain’s border regions via single-cell analysis and fate-mapping. This also identified a microglial subset at the surface of the choroid plexus, in direct contact with cerebrospinal fluid.
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Nature Neuroscience The diversity of brain #macrophages, including border-associated macrophages (BAMs) from the dura mater, subdural meninges, and choroid plexus, revealed with single-cell RNA sequencing, high-dimensional cytometry, and fate-mapping 44d
A novel cortico-intrathalamic circuit for flight behavior
Nature Neuroscience 48d 1 tweets
Dong, Wang et al. uncover a circuit linking Glu+cingulate inputs→PV+ neurons in the limbic thalamic reticular nucleus→intermediodorsal thalamic nucleus, and show that this cortico-intrathalamic circuit is a component of the fear circuitry and...
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Nature Neuroscience A corticothalamic circuit through the thalamic reticular nucleus (TRN) that controls flight in response to fear 48d
Evidence that recurrent circuits are critical to the ventral stream’s execution of core object recognition behavior
Nature Neuroscience 52d 2 tweets
Using model- and primate behavior-driven image selection with large-scale electrophysiology in monkeys performing core recognition tasks, Kar et al. provide evidence that automatically engaged recurrent circuits are critical for rapid object...
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Nature Neuroscience Recurrent circuits in the primate ventral stream are critical for rapid object identification 50d
Predictive and reactive reward signals conveyed by climbing fiber inputs to cerebellar Purkinje cells
Nature Neuroscience 51d 1 tweets
Cerebellar climbing fibers carry predictive and feedback signals about reward, expanding the role of the cerebellar cortex in the creation and evaluation of predictions.
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Nature Neuroscience Cerebellar climbing fiber inputs to Purkinje neurons signal reward expectation, delivery, and omission 51d
Memories light the corners of my mind
Nature Neuroscience 52d 2 tweets
Using light-activated ion channels to stimulate sensory and motivational pathways, Vetere and colleagues constructed fully artificial memories in mice. Mice preferred or avoided an odor they had never smelled before, depending on the pattern of...
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Nature Neuroscience Also check out the News and Views from ! 52d
Memory formation in the absence of experience
Nature Neuroscience 52d 10 tweets
Pairing an odor conditioned stimulus (CS) with an unconditioned stimulus (US) induces memory formation. Vetere et al. replace the real CS and US with direct optogenetic stimulation of the brain and create a fully artificial odor memory in mice.
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Nature Neuroscience . and used optogenetic stimulation to engineer a fully artificial olfactory fear memory in mice 52d
Dorsolateral prefrontal neurons mediate subjective decisions and their variation in humans
Nature Neuroscience 59d 2 tweets
The authors discover neurons in the human prefrontal cortex that encode subjective decisions and that may underlie the process by which opinions are formed. They also find how disruption of these neurons selectively interferes with the...
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Nature Neuroscience Neurons in the human dorsolateral prefrontal cortex (dlPFC) encode subjective decisions and may underlie opinion formation; focal disruption of the dlPFC diminished gradation between opposing decisions. 59d
A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data
Nature Neuroscience 66d 3 tweets
Wang et al. present a computational framework integrating multi-omics data to infer key schizophrenia risk genes from GWAS data. These genes are predominantly expressed in the developing brain and are enriched for targets of approved drugs.
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Nature Neuroscience A Bayesian computational framework for integrating multi-omics data to infer key #schizophrenia risk genes from #GWAS data 63d
Serotonin-mediated inhibition of ventral hippocampus is required for sustained goal-directed behavior
Nature Neuroscience 66d 4 tweets
Yoshida et al. show in mice that sustained engagement in motivated behavior requires suppression of ventral hippocampus activity through activation of median raphe serotonin neurons.
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Nature Neuroscience Sustained motivated behavior requires suppression of ventral #hippocampus activity via activation of median raphe #serotonin neurons 64d
The spatial correspondence and genetic influence of interhemispheric connectivity with white matter microstructure
Nature Neuroscience 65d 5 tweets
Mollink et al. establish a link between white matter microstructure and functional connectivity using MRI data from 11,354 individuals in the UK Biobank. GWAS identified genetic associations of these microstructure–function relationships.
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Nature Neuroscience MRI data from 11,354 individuals in the establishes a link between white matter microstructure and functional connectivity; #GWAS identified genetic associations of these microstructure–function relationships. 65d
Identification of neurodegenerative factors using translatome–regulatory network analysis
Nature Neuroscience 66d 1 tweets
To elucidate novel molecular mechanisms underlying neurodegeneration in Parkinson's disease, the authors generated mice for cell type-specific profiling of dopaminergic neurons. Regulatory network analysis of translatome libraries from dopaminergic...
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Nature Neuroscience We're mourning the passing of Paul Greengard, a transformative scientist and mentor. Here are some papers he published with us, which we think reflect the depth and breadth of his impact on neuroscience: , 66d
Cell type–specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs
Nature Neuroscience 66d 1 tweets
DARPP-32 phosphorylation is crucial to the actions of both psychostimulant and antipsychotic drugs. By using BAC transgenic mice to tag DARPP32 selectively in either striatonigral or striatopallidal neurons, the authors show that cocaine (a...
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Nature Neuroscience We're mourning the passing of Paul Greengard, a transformative scientist and mentor. Here are some papers he published with us, which we think reflect the depth and breadth of his impact on neuroscience: , 66d