Jake Dunning
Personal account/views. Infectious diseases consultant & researcher. Emerging and high consequence infections at PHE, Royal Free, UCL, Imperial & Oxford.
Thought Leader
| #283 | Infectious Disease |
Last synced from Twitter 81d ago
Study finds that not wearing a mask is linked to Anti-Social Personality Disorder
Those who don’t comply with Covid-19 containment measures were found to be more callous, hostile and deceitful
Jake Dunning
independent.co.uk/life-style/hea… What about those who do comply with masking rules, because they are law-abiding citizens, but resent doing so because they believe there is still no decent evidence that masking reduces or significantly limits spread at a population level? Socratesian PD?
81d
Serological surveillance of SARS-CoV-2: trends and humoral response in a cohort of public health workers
Background There is considerable debate about the rate of antibody waning after SARS-CoV-2 infection, raising questions around long-term immunity following both natural infection and vaccination. We undertook prospective serosurveillance in a large...
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Jake Dunning
**Pre-print, not yet peer reviewed** Serological surveillance of SARS-CoV-2: trends and humoral response in a cohort of public health workers medrxiv.org/content/10.110… ESCAPE is just one of many great COVID-19 studies from PHE. Happy to be a participant (and I remain IgG negative!)
83d
The LumiraDx SARS-CoV-2 Ag Test is a rapid microfluidic immunoassay detecting SARS-CoV-2 antigen
The test uses a nasal swab sample to detect antigen nucleocapsid protein in under 12 minutes at point of care. In clinical studies, the LumiraDx SARS-CoV-2 antigen test demonstrated 97.6% positive agreement versus PCR in patients tested within 12...
Jake Dunning
More info here including [US?] product inserts and quoted test performance data (only for those with symptoms)
83d
Boots to offer 12-minute Covid nasal swab test
The £120 nasal swab test will be available to people not showing any symptoms.
Jake Dunning
bbc.co.uk/news/health-54… "The aim is to offer customers peace of mind" & "the nasal swab test...will be available in selected stores in the UK to people who are not showing symptoms." But the LumiraDx website & supporting data state it's for use in those with suspected COVID-19?🤷♂️
83d
How London's top restaurants are skewering the Covid rules
“A table for six? No, sir, that is against the Covid-19 restrictions … unless you promise that your party will discuss business, not pleasure.” Some of London’s fanciest restaurants have discovered a loophole in the tier-2 coronavirus lockdowns...
Jake Dunning
Personal view: whether deliberate or a mistake, this is wrong. Group 'business' lunches cannot be justified in London right now. Loop holes or perceived ambiguities get spotted & exploited, so the opportunity needs to be removed. Avoid unnecessary mixing.
85d
Time to Reassess Tocilizumab’s Role in COVID-19 Pneumonia
In this issue of JAMA Internal Medicine, 3 important articles1-3 explore the use of tocilizumab in coronavirus disease 2019 (COVID-19) pneumonia. Tocilizumab is a humanized monoclonal antibody that binds human interleukin 6 (IL-6) receptors. It is...
Coronavirus (COVID-19) Infection Survey pilot - Office for National Statistics
Estimates for England, Wales and Northern Ireland. This survey is being delivered in partnership with University of Oxford, University of Manchester, Public Health England and Wellcome Trust.
Repurposed antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results
BACKGROUND WHO expert groups recommended mortality trials in hospitalized COVID-19 of four re-purposed antiviral drugs. METHODS Study drugs were Remdesivir, Hydroxychloroquine, Lopinavir (fixed-dose combination with Ritonavir) and Interferon-β1a...
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Jake Dunning
*PRE-PRINT not yet peer reviewed* SOLIDARITY trial findings. What now for remdesivir?
94d
Longitudinal antibody and T cell responses in Ebola virus disease survivors and contacts: an observational cohort study
The continuous high titre of neutralising antibodies and increased T cell response
might support the concept of long-term protective immunity in survivors. The existence
of antibody and T cell responses in contacts of individuals with Ebola virus...
Coronavirus (COVID-19) in the UK
GOV.UK Coronavirus dashboard
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Jake Dunning
A beta version of the new gov.uk #COVID19 data dashboard is now available: coronavirus-staging.data.gov.uk Please don't @ me with any comments or suggestions - there is a feedback button at the top of the page.
96d
Tracking SARS-CoV-2 in Sewage: Evidence of Changes in Virus Variant Predominance during COVID-19 Pandemic
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), responsible for the ongoing coronavirus disease (COVID-19) pandemic, is frequently shed in faeces during infection, and viral RNA has recently been detected in sewage in some countries....
Jake Dunning
More on coronaviruses in sewage, this time from colleagues @NIBSC_MHRA who have longstanding expertise in testing sewage samples (for enteroviruses). Tracking SARS-CoV-2 in Sewage: Evidence of Changes in Virus Variant Predominance during COVID-19 Pandemic
97d
National flu and COVID-19 surveillance reports
National influenza and COVID-19 report, monitoring COVID-19 activity, seasonal flu and other seasonal respiratory illnesses.
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Jake Dunning
In case you are looking for this week's @PHE_uk #COVID19 weekly surveillance report, it's now been combined with surveillance for influenza and other respiratory viruses. Still the same great COVID-19 content - just with added flu (i.e. all in one place).
100d
Bacteria-fighting cells in the airways boosts infection risk from viruses | Imperial News | Imperial College London
Having more bacteria-fighting immune cells in the nose and throat may explain why some people are more likely to be infected by respiratory viruses.
ISARIC COVID-19 Clinical Data Report: 3 September 2020
ISARIC (International Severe Acute Respiratory and emerging Infections Consortium) partnerships and outbreak preparedness initiatives enabled the rapid launch of standardised clinical data collection on COVID-19 in Jan 2020. Extensive global uptake...
Homepage - GenOMICC COVID-19 Study
Why do some people become seriously ill with COVID-19 while others are hardly affected? Help us find out.
Today - 26/09/2020 - BBC Sounds
Including Sports Desk, Weather and Thought for the Day.
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Jake Dunning
bbc.co.uk/sounds/play/m0… Some great #COVID19 content on @BBCr4today this morning. Stupidly early for a Saturday morning, but thankfully available on BBC Sounds and well worth a listen. 1/4
113d
Coronavirus (COVID-19) Infection Survey pilot - Office for National Statistics
Estimates for England, Wales, and Northern Ireland. This survey is being delivered in partnership with University of Oxford, University of Manchester, Public Health England and Wellcome Trust.
Genetic mechanisms of critical illness in Covid-19
The subset of patients who develop critical illness in Covid-19 have extensive inflammation affecting the lungs and are strikingly different from other patients: immunosuppressive therapy benefits critically-ill patients, but may harm some...