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Robust neutralizing antibodies to SARS-CoV-2 infection persist for months
Science 86d 5 tweets
SARS-CoV-2 has caused a global pandemic with millions infected and numerous fatalities. Questions regarding the robustness, functionality, and longevity of the antibody response to the virus remain unanswered. Here we report that the vast majority...
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Science Magazine Antibody responses in ~30,000 patients with mild-to-moderate #COVID19 remained stable for 5 months, a new study shows. authors including believe "it is very likely" these levels may decrease the odds ratio of reinfection. 86d
Social connections with COVID-19-affected areas increase compliance with mobility restrictions
Science Advances 86d 1 tweets
We study the role of social connections in U.S. households’ compliance with mobility restrictions imposed in response to the COVID-19 pandemic, using aggregated and anonymized Facebook data on social connections and mobile phone data for measuring...
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Science Magazine A new study in finds that residents of U.S. counties with more social links to China or Italy – the first countries to report major #COVID19 outbreaks – were more likely to adhere to mobility restrictions early in the pandemic. 86d
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors
Science 89d 4 tweets
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is decorated with spikes, and viral entry into cells is initiated when these spikes bind to the host angiotensin-converting enzyme 2 (ACE2) receptor. Many monoclonal antibody therapies in...
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Science Magazine Researchers have designed inhibitors that block the interaction between #SARSCoV2 and human cell receptor ACE2, paving the way for therapeutics that could be delivered more easily than antibodies. Read more in Science 87d
COVID-19 can affect the heart
Science 92d 5 tweets
The family of seven known human coronaviruses are known for their impact on the respiratory tract, not the heart. However, the most recent coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has marked tropism for the heart...
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Science Magazine A new #SciMagPerspective reviews data on the growing and diverse impact of #SARSCoV2 on the hearts of patients and highlights a “fundamental and large hole” in researchers’ knowledge base regarding what drives this pathogenesis. Read more: 88d
Itaconate controls the severity of pulmonary fibrosis
Science Immunology 91d 2 tweets
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease associated with accumulation of extracellular matrix in the lung. Here, Ogger et al. define a role for itaconate in regulating fibrosis. Itaconate synthesis by macrophages is catalyzed by...
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Science Magazine Studying the fatal lung disease idiopathic pulmonary fibrosis in patients and mouse models, scientists have revealed that a metabolite called itaconate can help limit the lung scarring caused by this disease. Read more in : 88d
When our research internship went virtual, we needed a new mentorship approach
Science | AAAS 90d 3 tweets
How an undergrad and her summer research mentors learned to adjust their expectations
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Science Magazine "I wondered how I would learn a completely new topic and research style from 3000 kilometers and two time zones away." How an undergrad and her summer research mentors learned to adjust their expectations in a new #SciMagWorkingLife. 88d
A cellular sense of space and pressure
Science 99d 3 tweets
During health or disease, cells traverse great distances along complex landscapes of chemical and physical cues, for instance, to heal wounds or to seed cancer metastases in the body. They navigate through tight, fluid-filled tissue channels and...
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Science Magazine New research finds that embryonic, immune, and cancer cells sense confinement through deformation of their nucleus, adding to the emerging idea that the nucleus, besides its genetic functions, directly senses the cell's physical environment. ($) 88d
Applying for a Ph.D.? These 10 tips can help you succeed
Science | AAAS 849d 5 tweets
Our Letters to Young Scientists columnists offer their advice
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Science Magazine There's no one right way to apply to #GradSchool—but these 10 tips could help point you in the right direction. Learn more from : #WeekendReads 89d
Cross-reactive neutralization of SARS-CoV-2 by serum antibodies from recovered SARS patients and immunized animals
Science Advances 89d 1 tweets
The current COVID-19 pandemic is caused by SARS-CoV-2, a novel coronavirus genetically close to SARS-CoV, thus it is important to define the between antigenic cross-reactivity and neutralization. In this study, we first analyzed 20 convalescent...
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Science Magazine Antibodies in serum samples from patients infected during the 2003 SARS-CoV outbreak effectively neutralized SARS-CoV-2 infection in cultured cells, according to a new study in : #WeekendReads 89d
Social selectivity in aging wild chimpanzees
Science 92d 7 tweets
As humans age, we prioritize established positive friendships over the new, but risky, socializing we do when we are young. It has been hypothesized that this shift may come as our own sense of mortality kicks in. Rosati et al. analyzed a rare,...
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Science Magazine You've got a friend in me: Like humans, wild chimpanzees focus on fewer yet more meaningful friendships as they grow older, according to a new Science study, providing the first evidence that nonhumans exhibit age-related social selectivity. ($) 92d
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Science Magazine You've got a friend in me: Like humans, wild chimpanzees focus on fewer yet more meaningful friendships as they grow older, according to a new Science study, providing the first evidence that nonhumans exhibit age-related social selectivity. ($) 87d
Down-regulation of Beclin1 promotes direct cardiac reprogramming
Science Translational Medicine 92d 1 tweets
Reprogramming cardiomyocytes from other cell types could have therapeutic potential for cardiac diseases. Wang et al. studied the induction of cardiomyocytes from murine fibroblasts. They found that autophagy-related 5 (Atg5) regulated autophagy...
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Science Magazine A study in mice reveals two ways that regulate how fibroblast cells can be reprogrammed into heart cells. The research may help yield promising results for cardiac regeneration therapy. Learn more: ($) 92d
Transient cortical circuits match spontaneous and sensory-driven activity during development
Science 99d 6 tweets
As the brain develops, it does not simply get bigger. Like a building that depends on temporary scaffolds as its structures are assembled, the developing brain sets up the circuits that characterize the adult brain. Molnár et al. review the current...
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Science Magazine As the brain develops, it does not simply get bigger. A new #SciMagReview looks at the current state of knowledge about how brain connections are built and how autonomously established patterns are reshaped by activity from the sensory periphery. ($) 92d
Understanding COVID-19 vaccine efficacy
Science 93d 12 tweets
Vaccine efficacy in high-risk groups and reduced viral shedding are important for protection
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Science Magazine Having reliable evidence on direct & indirect protection #COVID19 candidate vaccines provide can help plan how to use approved vaccines in a coordinated way, write & in this #SciMagPerspective. 93d
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Science Magazine Having reliable evidence on direct & indirect protection #COVID19 candidate vaccines provide can help plan how to use approved vaccines in a coordinated way, write & in this #SciMagPerspective. 88d
Immiscible immunity
Science 97d 2 tweets
Oil and water do not mix. This simple fact drives the formation of the lipid-based boundaries of cells, nuclei, and most organelles that make life possible. But a simpler structure, the lipid droplet (LD), coalesces in the cell cytoplasm and...
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Science Magazine Lipid droplets (LDs) accumulate in cells to serve as lipid storage organelles. New research explores the relations between the antimicrobial activities of LDs and their function as a fuel depot for mitochondria. Learn more in this #SciMagPerspective: ($) 93d
The gut microbiome defines social group membership in honey bee colonies
Science Advances 100d 3 tweets
In the honey bee, genetically related colony members innately develop colony-specific cuticular hydrocarbon profiles, which serve as pheromonal nestmate recognition cues. Yet, despite high intracolony relatedness, the innate development of...
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Science Magazine Honey bee nestmates may partly depend on their gut microbes to recognize one another, a new study suggests, revealing how symbiotic bacteria can shape unique, colony-specific chemical cues on the pollinators’ bodies. 93d
Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense
Science 99d 5 tweets
Lipid droplets (LDs) accumulate in cells to serve as lipid storage organelles. They are also an attractive source of nutrients for many pathogens. Bosch et al. show that various proteins involved in innate immunity form complexes on LDs in response...
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Science Magazine Mammalian lipid droplets represent an intracellular first line of defense against microbial pathogens, researchers report in Science. The findings may help inform future antimicrobial strategies to help combat the rise of antibiotic resistance. ($) 93d
SMAR1 repression by pluripotency factors and consequent chemoresistance in breast cancer stem-like cells is reversed by aspirin
Science Signaling 94d 2 tweets
Cancer stem cells (CSCs) are tumor cells with stem cell-like qualities that promote tumor progression, adaption to stress, and resistance to chemotherapy. Bhattacharya et al . found that aspirin targets CSCs in a way that may enhance the efficacy of...
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Science Magazine Aspirin can disable the molecular pumps that #breastcancer cells use to expel chemotherapy drugs, suggesting that the well-known compound could be used to boost chemotherapies in patients with certain tumors. #aspirin 94d
Neuropilin-1 is a host factor for SARS-CoV-2 infection
Science 94d 14 tweets
SARS-CoV-2, the causative agent of COVID-19, uses the viral Spike (S) protein for host cell attachment and entry. The host protease furin cleaves the full-length precursor S glycoprotein into two associated polypeptides: S1 and S2. Cleavage of S...
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Science Magazine Helping explain what makes #SARSCOV2 so capable of infecting human cells, researchers in two independent studies discovered that the virus’s spike protein recognizes and binds a protein on the human cell surface called neuropilin-1 94d
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Science Magazine Helping explain what makes #SARSCOV2 so capable of infecting human cells, researchers in two independent studies discovered that the virus’s spike protein recognizes and binds a protein on the human cell surface called neuropilin-1 91d
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity
Science 94d 12 tweets
The causative agent of coronavirus induced disease 2019 (COVID-19) is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For many viruses, tissue tropism is determined by the availability of virus receptors and entry cofactors on the...
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Science Magazine Helping explain what makes #SARSCOV2 so capable of infecting human cells, researchers in two independent studies discovered that the virus’s spike protein recognizes and binds a protein on the human cell surface called neuropilin-1 94d
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Science Magazine Helping explain what makes #SARSCOV2 so capable of infecting human cells, researchers in two independent studies discovered that the virus’s spike protein recognizes and binds a protein on the human cell surface called neuropilin-1 91d
Contextualizing bats as viral reservoirs
Science 106d 5 tweets
Coronavirus disease 2019 (COVID-19) is the latest in a distressing tally of viral infections—including Ebola, Nipah, rabies, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome (MERS)—that have evolutionary origins or...
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Science Magazine A new #SciMagPerspective discusses current understandings on bats as reservoirs for potential zoonotic diseases and argue that their role in zoonotic disease requires more investigation before solutions can be found. 94d