Proteins evolve through the modular rearrangement of elements known as domains. It is hypothesized that extant, multidomain proteins are the result of domain accretion, but there has been limited experimental validation of this idea. Here, we...
Fyodor UrnovMaking Cas9 smaller: impactful and elegant work with fascinating basic science (evolution!) and clinical use (delivery!) implications.
Emotional CoI: my lab is in the @igisci as are the authors' @SavageCatsOnly lab + @doudna_lab - I swoon over both daily.
Doudna shares the prize with Emmanuelle Charpentier of France
Fyodor UrnovJennifer's and Emmanuelle's discovery changed EVERYTHING for the better, and I am convinced that the 21st century will be remembered as the Age of CRISPR - an Age that they started with their magnificent work.
Fyodor Urnov@daniela_witten [1/2] First, your statistics textbook is superb; thank you for making it available online - a great learning resource for my students and myself.
Re false positives in qPCR analysis for SARSCov2. Here's what I can offer from our @igisci diagnostic lab.
The next pandemic could be bioengineered in someone’s garage using cheap and widely available technology.
Fyodor Urnov.@wadhwa The next time you write about genome editing, PLEASE consult with a professional gene editor.
Your musings re CRISPR are the work of a dilettante in that space; note that the world already has plenty of data-unsupported alarmism about editing.
Fyodor Urnov@antonioregalado@ifeelgod Well, I have in the past.
Research studies such as @NiakanLab is doing must continue - it's real science.
What would justify an embryo edit for sickle if there is safe and effective in vivo delivery of a gene editor to a newborn? Because that will happen.
PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Fyodor UrnovThe data are conclusive: the "new" Pubmed is a giant cys-phe. I looked for, and found, the original Pubmed - the one that works, the one where "barton-g macrophage" yields 9 hits (it's 0 on the "new" one).
Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin gene (HTT), which codes for the pathologic mutant HTT (mHTT) protein. Since normal HTT is thought to be...
A month before the coronavirus outbreak at San Quentin, a group of scientists and health experts offered free COVID-19 testing to inmates and staff, but prison officials said they didn’t need their help.
Fyodor UrnovThe tragic #SARSCov2 outbreak at San Quentin could have been prevented by testing. @BrooksKTVU reports on how an offer from @igisci@UCBerkeley to do that testing was declined by SQ officials - TWICE.
This CANNOT be allowed to happen again. @KTVU
The COVID-19 testing center at the Broad is providing testing, training, and supplies to health agencies in eight hard-hit communities
Fyodor UrnovThe State of CA must do what the State of MA has done: directly coordinate with nonprofit and academic testing centers to expand testing in communities at risk.
The @broadinstitute is to be commended for this - phenomenal job.
California failed to establish an effective coronavirus testing system early on, leaving it far behind — even now — in the fight against COVID-19.
Fyodor Urnov>4 months into the pandemic in the US, LabCorp and Quest report #SARSCov2 results in ~SIX DAYS.
The institutional inertia @Emily_Baum so poignantly describes has now met this "cold light of reality," and @igisci we are SWAMPED with requests for testing.
Before public health officials can manage the pandemic, they must deal with a broken data system that sends incomplete results in formats they can’t easily use.
Fyodor UrnovThe @igisci@SARSCov2 diagnostic lab reports results electronically via a standardized digital interface we set up that connects our internal database to that of the County and the State (CalREDIE).
What this article describes does NOT have to be the case.
There is no evidence that hospital laboratories have falsified the number of COVID-19 positives. While false-positives can occur, experts agree that they are a rare event. On the contrary, false-negatives are hard to control as they can be due to...
Fyodor UrnovLies kill.
Truth can prevent that.
There is a pernicious lie propagated via Fb, Ig, and this platform that #SARSCoV2 testing labs falsify results to inflate the rate.
Here is the truth.
Please RT it.
Researchers reported Wednesday that they had turned a bacterial toxin into the world’s first editor of genes in mitochondria, the cell's power plant.
Fyodor Urnov"Yeah! Yeah!! Yeah!!!" ...
... is this morning's song about mitochondrial genome editing, which, as @sxbegle explains, all of us have wanted to do since forever - and now we can! - courtesy of @davidrliu@broadinstitute and #MougousLab @UW
San Quentin prison is dealing with the third-largest coronavirus outbreak in the United States: researchers fear that other prisons are at risk.
Fyodor UrnovIn a tragic triumph of hope over experience, officials at San Quentin rejected @igisci's and other offers of #SARSCov2 testing before and during the outbreak, and relied on Quest instead.
@amymaxmen's piece is an essential read - this CANNOT happen again.
Fyodor Urnov@xenoceratops@jhdcate@mbeisen We @igisci have a CLIA license for high complexity testing, and do not need CAP accreditation to result specimens. Setting this up was the mother of all team efforts. @amymaxmen wrote recently about the San Quentin tragedy that is on the same topic
Three studies showing large DNA deletions and reshuffling heighten safety concerns about heritable genome editing.
TO MAKE A BABY.
@GaetanBurgio, yours truly, and all professional genome editors are against it.
See lucid summary of new data and their implications by @heidiledford.
Noha Aboelata, the head of a community health centre in Oakland, California, tailors testing to suit communities of colour.
Fyodor UrnovIn East Oakland, 11 mi from @UCBerkeley, the #SARSCov2 rate at a community clinic is 14.4% (@igisci does some of the testing). @amymaxmen's interview with the lead clinician is a bracing snapshot of structural racism in US healthcare and a call to action.
-Beta thalassemia: Two patients are transfusion independent at 5 and 15 months after CTX001 infusion; data demonstrate clinical proof-of-concept for CTX001...
Fyodor UrnovA functional cure via #CRISPR genome editing for Victoria Gray who HAD sickle cell disease, and two folks who HAD thalassemia! Bravo to @CRISPRTX and fingers (other than zinc ;-)) crossed for subjects on @SangamoTx trial that pioneered this approach.