Kevin Mitchell
I am a neurogeneticist interested in the genetics of brain wiring and its contribution to variation in human faculties. Author of INNATE (2018). kjmitchell.com
Last synced from Twitter 12m ago
Higher order thalamus encodes correct goal-directed action
The thalamus is the gateway to the cortex. Cortical encoding of sensory information can therefore only be understood by considering the influence of thalamic processing on sensory input. Despite modulating sensory processing, little is known about...
This map shows why it would be 'terrifying' to open Canada-U.S. border
A map showing the startling contrast between Canada and the United States in the fight against COVID-19 has an infectious disease expert "terrified" at the thought of reopening the border.
Science Fictions: The Epidemic of Fraud, Bias, Negligence and Hype in Science: Amazon.co.uk: Ritchie, Stuart: 9781847925657: Books
Buy Science Fictions: The Epidemic of Fraud, Bias, Negligence and Hype in Science by Ritchie, Stuart (ISBN: 9781847925657) from Amazon's Book Store. Everyday low prices and free delivery on eligible orders.
Deconstructing the sources of genotype-phenotype associations in humans
Efforts to link variation in the human genome to phenotypes have progressed at a tremendous pace in recent decades. Most human traits have been shown to be affected by a large number of genetic variants across the genome. To interpret these...
‘We are worried’: Taoiseach warns plan to reopen all pubs on July 20th may be delayed
Martin says gardaí carried out about 5,500 inspections of pubs and restaurants over weekend
111: The cumulative advantage of academic capital (with Chris Jackson)
We chat with Chris Jackson (Imperial College, London) about the "Matthew Effect" in academia, how we can improve work/balance, and whether we should stop citing shitty people.
Publicly available hiPSC lines with extreme polygenic risk scores for modeling schizophrenia
Schizophrenia (SZ) is a common and debilitating psychiatric disorder with limited effective treatment options. Although highly heritable, risk for this polygenic disorder depends on the complex interplay of hundreds of common and rare variants....
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Kevin Mitchell
Publicly available hiPSC lines with extreme polygenic risk scores for modeling schizophrenia biorxiv.org/content/10.110… - nice work from @kristenbrennand + colleagues generating cells w/ diff polygenic b/g risk in which to assess effects of CRISPR'd rare mutations
19h
Deviation from baseline mutation burden provides powerful and robust rare-variants association test for complex diseases
The identification of rare variants that contribute to complex diseases is challenging due to low statistical power. Here we propose a novel and powerful rare variants association test based on the deviation of the observed mutational burden in a...
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Kevin Mitchell
Deviation from baseline mutation burden provides powerful and robust rare-variants association test for complex diseases
19h
Single-molecule imaging of transcription dynamics in somatic stem cells
Single-molecule fluorescence in situ hybridization and live-cell imaging are used to study the contribution of transcriptional noise to stem cell heterogeneity, revealing that stochastic transcription dynamics are conducive to concomitant stem-cell...
Jülicher Kolloquium - Blake Richards (6 July 2020)
Jülicher Kolloquium
Monday, 6 July 2020. 2:00pm - 3:30pm
Virtual Lecture
The new Helmholtz International BigBrain Analytics Learning Laboratory HIBALL and Helmholtz AI Local at Forschungszentrum Jül
Ireland could eliminate Covid-19 ‘within months’ with tighter restrictions
Expert urges ‘dramatic rethink’ rather than allowing virus become ‘permanent disease’
Coronavirus: No further deaths reported as doctor warns second wave ‘weeks away’
NPHET records 18 new confirmed cases bringing total in Republic to 25,527
Oscar Marin's World Wide Neuro Forum - Crowdcast
Register now for World Wide Neuro's event on Crowdcast, scheduled to go live on Thursday July 09, 2020 at 5:00 pm CEST.
Ruth Negga: ‘People who say they don’t consider skin colour... are you f**king blind?’
Black Irish Lives: The actor on growing up in Ireland, the film industry, and Black Lives Matter
Coronavirus: People coming into Ireland should take multiple tests, expert says
People arriving into Ireland should be tested more than once for coronavirus to improve detection rates, according to an expert.
Deadly Brain-Eating Amoeba Confirmed in Florida
Naegleria fowleri can lead to a dangerous infection of the brain that “destroys the brain tissue and is usually fatal.”
239 Experts With 1 Big Claim: The Coronavirus Is Airborne
The W.H.O. has resisted mounting evidence that viral particles floating indoors are infectious, some scientists say. The agency maintains the research is still inconclusive.
Former WHO director Anthony Costello: 'Opening pubs before schools says something about our priorities'
The paediatrician and member of Independent Sage on Matt Hancock, the likelihood of a vaccine and why 50,000 deaths were preventable
'Crystal clear' drunk people can't socially distance, say police in England
Police Federation chair says revellers would not adhere to one-metre-plus rules as pubs opened on Saturday
Crowds gathering in Dublin city centre ‘ugly image’ for the capital, say vintners
Publican group condemn lack of social distancing in Dublin city street party