Greater novelty and diversity in one’s daily physical environment is associated with positive affect, and functional connectivity within a hippocampal–striatal circuit is related to the strength of this effect.
There is considerable symptom heterogeneity in major depressive disorder. Here, we
show that melancholia, which is a specifier for major depressive disorder in the DSM-5
and is meant to identify a more homogeneous subgrouping of individuals,...
Children exhibiting extreme anxious temperament (AT) are at an increased risk to develop
anxiety and depression. Our previous mechanistic and neuroimaging work in young rhesus
monkeys links the central nucleus of the amygdala (Ce) to AT and its...
Alex ShackmanTranscriptional Profiling of Primate Central Nucleus of the Amygdala Neurons to Understand the Molecular Underpinnings of Early Life Anxious Temperament
Observational data on COVID-19 including hypothesised risk factors for infection and progression are accruing rapidly. Here, we highlight the challenge of interpreting observational evidence from non-random samples of the population, which may be...
Charakteristische normale Formen der elektrischen Hirntätigkeit bei direkter Ableitung von der freigelegten menschlichen Hirnrinde werden beschrieben. Das Gebiet maximaler α-Aktivität beginnt in der...
This Special Communication argues against changing the definition of posttraumatic stress disorder in DSM-5.
Alex Shackmanwowza - oldy but "goody" (by which i mean a disturbing indictment of expert consensus approaches to psychopathology) -- Unintended Consequences of Redefining Posttraumatic Stress Disorder
Attention-bias modification (ABM) is a novel treatment for anxiety disorders. We tested the contribution of two possible factors implicated in ABM’s efficacy: t...
Alex ShackmanWhat Drives Symptom Reduction in Attention Bias Modification Treatment? A Randomized Controlled Experiment in Clinically Anxious Youths - Marian Linetzky, Jeremy W. Pettit, Wendy K. Silverman, Daniel S. Pine, Yair Bar-Haim
Effectively minimizing head motion continues to be a challenge for the collection of functional magnetic resonance imaging (fMRI) data. The development of individual-specific custom molded headcases have been offered as a promising solution to...
Alex ShackmanCustom-molded headcases have limited efficacy in reducing head motion for fMRI
The way in which the brain prioritises processing of information relevant for our current goals is widely contested. Many studies implicate the dorsolateral prefrontal cortex (dlPFC), and propose that it drives brain-wide focus by biasing processing...
Alex Shackman#feredoes - Concurrent neuroimaging and neurostimulation reveals a causal role for dlPFC in coding of task-relevant information
On top or underneath: where does the general factor of psychopathology fit within a dimensional model of psychopathology? - Philip Hyland, Jamie Murphy, Mark Shevlin, Richard P. Bentall, Thanos Karatzias, Grace W.K. Ho, Daniel Boduszek, Eoin McElroy
Alex Shackman#pfactor @hitop_system - higher-order vs bifactor - On top or underneath: where does the general factor of psychopathology fit within a dimensional model of psychopathology?