Read the latest article version by Ruklanthi de Alwis, Tran My Phuc, Benjamin Yu Hang Bai, Nhi Le Thi Quynh, Pham Thi Thanh Tam, Tran Thi Ngoc Dung, Nguyen Thi Thanh Nhan, Chau Vinh, Ho Van Hien, Le Thanh Hoang Nhat, Nguyen Thi Thu Hong, Nguyen Thi...
Whole-genome sequencing of inflammatory bowel disease patient samples allows insight
into mutational burdens and processes associated with disease, including putative
driver mutations positively selected in the diseased colon.
The BSG typically awards the President’s Medal at the plenary of the Annual Meeting, due to take place in June 2020. However, due to the circumstances of 2020, BSG has awarded the President’s Medal for 2020 remotely and will invite […]
Carl AndersonOn Sunday, myself and other members of my research team @sangerinstitute will walk 10K to raise money for @CrohnsColitisUK, a charity which supports people in the UK living with #IBD. Please give what you can to help us achieve our fundraising goals!
Carl AndersonTomorrow, myself and members of my lab @sangerinstitute will walk 10K for @CrohnsColitisUK. This is completely vicarious, we've only ever applied for one grant from CCUK - and it was rejected! Please donate to fund research into new IBD therapies.
Carl is raising money to help Crohn’s & Colitis UK
Carl AndersonIn a moment of complete and utter madness, I've gone and signed up for the Great North Run in September to fundraise for @CrohnsColitisUK. Please donate generously to make the training seem less bleak! Any half marathon tips welcomed!
Inflammatory bowel disease (IBD) is a chronic inflammatory disease associated with increased risk of gastrointestinal cancers but our understanding of the effects of IBD on the mutational profile and clonal structure of the colon is limited. Here,...
Carl AndersonCheck out our latest preprint (bit.ly/32HNslc). A little different from the usual stuff. @SigurOlafsson uses laser capture microdissection and whole-genome sequencing of individual crypts to describe the mutational and clonal landscape of the IBD colon. #somaticIBD 1/n
Measles virus is a highly infectious lymphotropic virus associated with an extended period of immunosuppression after resolution of acute viremia. Petrova et al . sequenced the immunoglobulin gene repertoire of naïve and memory B cells in paired...
Anti-tumor necrosis factor (anti-TNF) therapies are the most widely used biologic
drugs for treating immune-mediated diseases, but repeated administration can induce
the formation of anti-drug antibodies. The ability to identify patients at...
Genetic association studies have identified 215 risk loci for inflammatory bowel disease –, which have revealed fundamental aspects of its molecular biology. We performed a genome-wide association study of 25,305 individuals, and meta-analyzed ...
Carl Anderson@BrentRichards19@markmccarthyoxf We really find eQTLs to be helpful when mapping to know causal genes and drug target pathways. See bit.ly/2kKfsVD. Why the difference? Availability of eQTLs for disease relevant tissues and environments? We see v.few colocs with unstimulated immune cells, for example.
The CTCF paralogue BORIS is upregulated in transcriptionally reprogrammed neuroblastoma cells rendered resistant to targeted therapy, in which it promotes regulatory chromatin interactions that maintain the resistance phenotype.
Carl AndersonAnd here was me thinking he was completely useless and incompetant