Anshul Kundaje
Genomics, Machine Learning, Statistics, Big Data and Football (Soccer). Views are my own and do not reflect my employers
Last synced from Twitter 2m ago
Our choice is Joe Biden*
This year’s general election ballot presents the voter with a dilemma. We have wrestled with this year’s choices, as we imagine many voters have. Up and down the ticket we
Broad transcriptional dysregulation of brain and choroid plexus cell types with COVID-19
Though SARS-CoV-2 primarily targets the respiratory system, it is increasingly appreciated that patients may suffer neurological symptoms of varied severity. However, an unbiased understanding of the molecular processes across brain cell types that...
A More Prosperous Future for the Indian American Community: Op Ed by Vice President Biden for India-West
Four years ago in November, one of the last events I hosted at the Vice President’s residence was a Diwali reception. Here I was, an Irish Catholic Vice President opening
The Pandemic Is an Intuition Nightmare
As the U.S. heads towards the winter, the country is going round in circles, making the same conceptual errors that have plagued it since spring.
Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin
SHARE-seq, a highly scalable approach to measure chromatin accessibility and gene
expression in the same single cell, links distal regulatory elements to key lineage-specifying
genes and finds that chromatin accessibility foreshadows gene expression.
Life Science Research Professional 1 in School of Medicine, Stanford, California, United States
The Gifford lab in the Departments of Pediatrics and Genetics, and the BASE Institute is seeking a highly motivated Life Science Research...
Trump’s Taxes Show He Engineered a Sudden Windfall in 2016
Over $21 million in highly unusual payments from the Las Vegas hotel Donald Trump owns with Phil Ruffin were routed through other Trump companies, then paid out in cash.
Single-Cell Multiomics Sequencing Reveals Prevalent Genomic Alterations in Tumor Stromal Cells of Human Colorectal Cancer
Zhou et al. provide evidence for the prevalence of somatic copy number alterations
in fibroblasts, immune cells, and endothelial cells in both colorectal cancer and
normal tissues. The proportions of aneuploid fibroblasts in tumors are much...
I Will Vote
Confirm where you vote and learn what you need to cast your ballot.
The Case Against Donald Trump
The president of the United States poses a threat to our collective existence. The choice voters face is spectacularly obvious.
insitro Strengthens Machine Learning-Based Drug Discovery Capabilities with Acquisition of Haystack Sciences
insitro, a machine learning driven drug discovery and development company, today announced the acquisition of Haystack Sciences, a private company adv
Cancer Immunotherapy: Beyond Checkpoint Blockade
Blocking antibodies to the immune checkpoint receptors or their ligands have revolutionized the treatment of diverse malignancies. Many tumors are recognized by adaptive immunity, but these adaptive responses can be inhibited by immunosuppressive...
Deregulation of Retroelements as an Emerging Therapeutic Opportunity in Cancer
Nearly half of the human genome is comprised of repetitive elements that are tightly
regulated to protect the host genome from deleterious consequences associated with
their inappropriate activation. Cancer cells often misexpress these elements, in...
Joe Biden greet with Parkland students before speech with Gabby Giffords at MFOL.
Joe Biden greet with Parkland students before speech with Gabby Giffords at MFOL.
Opposing Effects of Cohesin and Transcription on CTCF Organization Revealed by Super-resolution Imaging
The chromatin organizing proteins CTCF and cohesin are known to exhibit spatial heterogeneity,
forming “clusters” inside the nucleus. Here, Gu, Comerci, McCarthy, et al. use super-resolution
microscopy to measure quantitative parameters governing...
DNA mismatches reveal conformational penalties in protein–DNA recognition
A high-throughput assay that introduces mismatched base pairs into the DNA sequence shows that mismatches can increase transcription factor binding affinity by prepaying some of the energetic cost of distorting the DNA.
CellRank for directed single-cell fate mapping
Computational trajectory inference enables the reconstruction of cell-state dynamics from single-cell RNA sequencing experiments. However, trajectory inference requires that the direction of a biological process is known, largely limiting its...