Antonio Regalado
Progress in science depends on new techniques, new discoveries and new ideas, probably in that order - {Sydney Brenner}. I write about biotechniques
Thought Leader
#377 Genetics
Last synced from Twitter 18m ago
The Next Phase of Human Gene-Therapy Oversight | NEJM
New England Journal of Medicine 6d 13 tweets
Perspective from The New England Journal of Medicine — The Next Phase of Human Gene-Therapy Oversight
Express Scripts staking out million-dollar gene therapies
U.S. 7d 6 tweets
Express Scripts Holding Co built a multi-billion enterprise pressuring drug companies to lower their prices for U.S. patients. Now it is quietly building a side business: getting paid to help drug companies dispense a new generation of high-priced...
Reporter, Pharma in NEW YORK, New York, United States
View All Jobs/Careers 8d 1 tweets
Winter Reporting Internship Covering Science and Health Care in NEW YORK, New York, United States
View All Jobs/Careers 8d 1 tweets
Scientists Cracked a Deadly DNA Puzzle. Then Came the Hard Part
Bloomberg.com 8d 4 tweets
In 2002, renowned scientist Phillip Sharp co-founded Alnylam Pharmaceuticals Inc. after learning about an intriguing discovery: Researchers had figured out how to “silence” biological messages sent by the genetic code in worms.
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Antonio Regalado Nice potted history of RNA interference -- genetic control technology that took 20 years to become a drug. ....also cautionary tale on for CRISPR hype. 8d
Clues to Your Health Are Hidden at 6.6 Million Spots in Your DNA
Nytimes.com 8d 24 tweets
With a sophisticated new algorithm, scientists have found a way to forecast an individual’s risks for five deadly diseases.
Antonio Regalado Idea of polygenic risk scores for medicine make first appearance in the New York Times featuring and a Nature Genetics paper reviewing his work over the last few year. 8d
Terms of Service Violation
Bloomberg.com 19d 3 tweets
Antonio Regalado a “glaring” failure to live up to a scary headline. If there’s a threat in aggregate data Bloomberg...let’s hear what it is with a lot more clarity. 9d
Monsanto Has Plans to Spray Cropland with Genetic Molecules
Antonio Regalado - MIT Technology Review 11d 2 tweets
Deep inside its labs, Monsanto is learning how to modify crops by spraying them with RNA rather than tinkering with their genes.
Antonio Regalado More recently, I wrote about Monsanto's big idea for "spray-on GMOs". Basically, RNA interference sprays you could spray on a plant to kill bugs or alter it. 11d
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Antonio Regalado A jar of pure RNA. Cost $1 million a few years ago. Now almost cheap enough to spray on farms. 1106d
RNAI-wsj | Rna Interference | Gene
Scribd 11d 1 tweets
2002 Wall Street Journal front page story on discovery of RNA interference or RNAi. Featuring Craig Mello, Andrew Fire and others.
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Antonio Regalado August 2002 scoop on RNA interference below was published on PG 1 of the Wall Street Journal. can't be found online anymore. Boy, that was a different news cycle. Four years passed between Mello and Fire's 1998 discovery of RNAi and first big story. 11d
Gung ho: Alnylam lands historic FDA OK on patisiran, revving up the first global rollout for an RNAi breakthrough
John Carroll - Endpts.com 11d 7 tweets
“A lot of people think it’s winter out there for RNAi. But I think it’s springtime.” — Alnylam CEO John Maraganore, NYT, February 7, 2011. Marketing season has officially arrived for RNAi, just two decades in the making.  On Friday, the FDA approved...
China’s Challenge Is America’s Opportunity
Nytimes.com 13d 17 tweets
The president of M.I.T. says the U.S. must respond urgently as China advances in science and technology.
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Antonio Regalado MIT President: "China is likely to become the world’s most advanced technological nation ... in not much more than a decade." 13d
Highly efficient ssODN-mediated homology-directed repair of DSBs generated by CRIPSR/Cas9 in human 3PN zygotes. - PubMed - NCBI
Ncbi.nlm.nih.gov 134d 2 tweets
Mol Reprod Dev. 2018 Apr 6. doi: 10.1002/mrd.22983. [Epub ahead of print]
Antonio Regalado Also previously, a small N embryo editing paper from China that did not find support for Mitalipov. "Highly efficient ssODN-mediated homology-directed repair of DSBs generated by CRISPR/Cas9 in human 3PN zygotes." /END 13d
Ma et al. reply
Nature 13d 3 tweets
Ma et al. reply
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Antonio Regalado Lengthy 14 page reply to the critiques above, also today, by Mitalipov team. 13d
RAD51 Enhances Zygotic Interhomolog Repair
bioRxiv 190d 2 tweets
Recent advances in CRISPR/Cas-based genome editing, including three-component CRISPR, the use of long single-strand donors, enhanced microhomology-mediated end-joining (MMEJ), and pharmacological approaches have greatly improved knock-in (KI)...
Antonio Regalado Previously, a preprint supporting Mitalipov's finding from Guoping Feng at MIT. "RAD51 Enhances Zygotic Interhomolog Repair" 13d
Correction of a pathogenic gene mutation in human embryos
Nature 80d 3 tweets
CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.
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Antonio Regalado Here's some links for people who like details: Original Aug 2017 paper by Mitalipov: Press coverage: Doubts raised that same month: 13d
Doubts raised about CRISPR gene-editing study in human embryos
Nature News & Comment 354d 5 tweets
Alternative explanations challenge whether technique actually fixed a genetic mutation as claimed.
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Antonio Regalado Here's some links for people who like details: Original Aug 2017 paper by Mitalipov: Press coverage: Doubts raised that same month: 13d
Inter-homologue repair in fertilized human eggs?
Nature 13d 3 tweets
Inter-homologue repair in fertilized human eggs?
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Antonio Regalado Today, critiques officially published "Inter-homologue repair in fertilized human eggs?" by Dieter Egli & Maria Jasin: "Large deletions induced by Cas9 cleavage" by Fatwa Adikusuma and Paul Thomas 13d
Large deletions induced by Cas9 cleavage
Nature 13d 7 tweets
Large deletions induced by Cas9 cleavage
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Antonio Regalado Today, critiques officially published "Inter-homologue repair in fertilized human eggs?" by Dieter Egli & Maria Jasin: "Large deletions induced by Cas9 cleavage" by Fatwa Adikusuma and Paul Thomas 13d
US scientist who edited human embryos with CRISPR responds to critics
Antonio Regalado - MIT Technology Review 13d 2 tweets
Can we safely fix the DNA of human embryos in a lab dish?
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Antonio Regalado Today's brawl in Nature over whether editing human embryos with CRISPR really happened or not. 13d
Patients Seek Out Cancer Blood Tests
Antonio Regalado - MIT Technology Review 14d 1 tweets
New diagnostics can find the DNA that drives a tumor, but evidence that they help patients is missing.
Antonio Regalado back in 2015 we described the introduction of these DNA tests (from Foundation Medicine, Guardant, etc) into the market as a "global field experiment" since, even though the DNA data might be accurate, no one knew if they provided any actual benefit. 14d