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Neuroscience of everything from chromatin to circuits and amyloidosis to autism. No longer practicing self-hatred. Opinions my own.
Last synced from Twitter 1m ago
Grumpy Cat, who entertained millions online, dies at age 7
MORRISTOWN, Ariz. (AP) — Grumpy Cat, whose sourpuss expression entertained millions on the internet, has died at age 7. Her owners wrote on social media Friday that she experienced complications from a urinary tract infection and "passed away...
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Proof that having a grumpy attitude will lead you to an early grave #GrumpyCat
4d
Single-cell genomics identifies cell type–specific molecular changes in autism
Autism manifests in many ways. Despite that diversity, the disorder seems to affect specific cellular pathways, including those observed in the neocortex of patients' brains. Velmeshev et al. analyzed the transcriptomes of single brain cells,...
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Big early salvo in the application of single-cell #RNAseq to understanding the #autism phenotype. Small # of cases, but enough cells to identify substantive changes in neurons and #microglia
4d
University of Georgia Entomologist Marianne Shockley Dies
The young faculty member was active in outreach and teaching.
Darinka Obradovich | The DAISY Foundation
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Let me promote the excellence of my wife, who has now received one of the highest honors in #nursing - the #DAISY award from the @daisyfoundation #NursingWeek
10d
A Disinhibitory Microcircuit Mediates Conditioned Social Fear in the Prefrontal Cortex
Prefrontal cortex plays an essential role in fear expression. Xu et al. reveal a disinhibitory
microcircuit in prefrontal cortex through interactions between interneuron subtypes
and suggest that SST INs-mediated disinhibition represents an...
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Enjoy your weekends everyone, I'm gonna stretch out in the hammock under record-breaking temperatures with some Sst to PV disinhibition mediating social fear in the prefrontal cortex from the latest @NeuroCellPress
10d
Young Seattle residents unsatisfied with nearly everything about the city, new survey finds
How do Seattleites' perceptions of their own town stack up to other U.S. cities? Not great, according to a new survey of young people across the country.
International bike expert's advice to Seattle: 'Make it difficult for people to drive'
Author Peter Walker has researched bike infrastructure around the world — he says Seattle's has some glaring gaps.
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I appreciate advice of @peterwalker99 and others to make #Seattle more #bike-friendly but there are many problems, including that Seattle probably has more elevation than Utrecht
12d
Finance-Shaming Article About ’Nonessential’ Spending Fires People Up
The research study was commissioned by a life insurance company, which should tell you everything you need to know.
Voltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamics
A combination of improved near-infrared voltage indicators, high-speed microscopes and targeted gene expression schemes enabled simultaneous in vivo optogenetic control and recording of voltage dynamics in multiple neurons in the hippocampus of...
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Combined #optogenetics with soma-localized CheRiff and voltage imaging with the QuasR #GEVI in vivo!
14d
Stanford researchers identify brain region activated by Pokémon
Adults who played Pokémon video games extensively as children have a brain region that responds preferentially to images of Pikachu and other characters from...
Closure of high-tech medical firm Arivale stuns patients: ‘I feel as if one of my arms was cut off’
Once touted as "the Google or Microsoft" of genomic "wellness" services, Seattle-based Arivale pulled the plug this week. "We were about 10 years too early," says its CEO.
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I'm heartbroken: Closure of high-tech medical firm Arivale stuns patients: ‘I feel as if one of my arms was cut off’ | The Seattle Times
24d
Biden says he's 'more cognizant' of private space after allegations
On ABC's "The View," former Vice President Joe Biden admitted he thought about whether he should hug the show's hosts when he walked on the set.
Visualizing the Ranking of 100 Common Careers
Not all jobs are created equal - see this list of 100 common careers ranked based on income, stress levels, growth potential, and other factors.
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University Professor is apparently "very low stress" while Social Media Manager is "Very High". So quit yer bitchin and think about all the poor souls working for @jack
24d
Amy Adams probably will win her Oscar for "Hillbilly Elegy" and that's a damn shame
Knowing the Academy, Ron Howard's Netflix adaptation of J.D. Vance's facile "culture in crisis" book is a sure bet
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I wanted to hate this piece from @eekshecried because I too am the son of Appalachian parents and grew up in low end Trump Country before getting a Yale professional degree, but it's actually rather spot on. I only wish I'd written my #HillbillyElegy first
25d
Dengue researcher faces charges in vaccine fiasco
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Parents brought pictures of children immunized with Dengvaxia to a 2018 hearing at the Philippine Senate.
PHOTO: NOEL CELIS/AFP/GETTY IMAGES
A prominent pediatrician and medical researcher in the Philippines has been indicted...
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note to self: don't get involved in anything that has clinical implications in the Philippines
25d
School daze! Misspelled school crosswalk found in Doral
Well, it looks like someone in Doral isn't going to win the spelling bee this year.
Synthetic Speech Generated from Brain Recordings
The technology could one day restore the voices of people who have lost the ability to speak due to paralysis and other forms of neurological damage.
Single-Cell Transcriptomic Evidence for Dense Intracortical Neuropeptide Networks
Seeking insight into homeostasis, modulation and plasticity of cortical synaptic networks, we analyzed results from deep RNA-Seq analysis of 22,439 individual mouse neocortical neurons. This work exposes transcriptomic evidence that all cortical...
Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play
VanRyzin et al. demonstrate that microglia in the developing amygdala engulf and kill
otherwise viable newborn astrocytes, establishing sex differences in social circuits.
This process, which depends on gonadal hormones and endocannabinoid...