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Neuroscience of everything from chromatin to circuits and amyloidosis to autism. No longer practicing self-hatred. Opinions my own.
Last synced from Twitter 19m ago
Cellular and Molecular Probing of Intact Human Organs
Zhao et al. present an approach for intact human organ mapping that uses a new tissue
permeabilization method to clear and deeply label whole organs followed by light-sheet
microscopy imaging and a deep learning-based pipeline for 3D reconstruction...
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ooh nice - clearing, light sheet, deep learning for human tissue
4d
Conservatives and liberals have similar physiological responses to threats
A previous study reported that conservatives have stronger physiological responses to threatening stimuli than liberals. A new study from the United States (n = 202 and 352) and the Netherlands (n = 81) does not support the conclusions of the...
Harley-Davidson/Donald Trump and Sarah Palin 2016
Shop donna_stinson's closet or find the perfect look from millions of stylists. Fast shipping and buyer protection. Crazy shirt! Donald Trump and Sarah Palin in a battle over presidency. dramatic scene of Donald Trump holding a gun and Sarah Palin...
City Plots How To Grow Neuro Economy | New Haven Independent
The economic impact of Yale New Haven Hospital’s planned new $838 million neuroscience center should extend well beyond the realm of the biosciences — potentially opening up new opportunities in...
The Myc tag monoclonal antibody 9E10 displays highly variable epitope recognition dependent on neighboring sequence context
Knowing whether a given antibody is specific for its intended target or is sensitive to posttranslational modifications of that target is critical for interpreting experimental data generated with antibody reagents. Two Research Resources from the...
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Your experiment is only as good as your pimary antibody. Sequence context matters - even under denaturing conditions, and you cannot assume the epitope is completely known
6d
What a Trump Rally Looks Like From the Inside
The president was in New Hampshire too, and so were his admirers.
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Sigh @nytimes. I feel for these writers who need work, but haven't we seen this story a hundred times?
7d
Rage Against The Machine Unveil "Public Service Announcement" Reunion Tour Dates
Photo via RATM Facebook page After announcing their reunion in November of 2019 following a nine-year hiatus and setting a handful of festival appearances
Genentech, Lilly Fail to Meet Primary Endpoint in Alzheimer's Trial
DIAN-TU-001 is a Phase II/III trial that tested two therapies compared to placebo, Genentech and Roche’s gantenerumab and Eli Lilly and Company’s solanezumab.
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Another blow to anti-amyloid therapy ... this time with early onset autosomal dominant AD. Genentech, Lilly Fail to Meet Primary Endpoint in Alzheimer's Trial | BioSpace biospace.com/article/eli-li… #jobs
8d
FDA and NIH let clinical trial sponsors keep results secret and break the law
Science investigation of ClinicalTrials.gov reveals that federal promises to enforce trial transparency have fizzled
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Industry does much better than academia or government with regard to on-time reporting of clinical trial data
8d
A new coronavirus associated with human respiratory disease in China
A new coronavirus associated with human respiratory disease in China
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Reviewed but incompletely edited Coronavirus manuscript. But don't read it if you don't "believe" in climate change, as then you think @nature is #fakenews
12d
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Join @sejdevries of @AllenInstitute
Live Chat: Navigating Team Science for Individuals and Institutions, 2/13 @ 2pm EST
12d
Associations of Meat, Poultry, or Fish Intake With Incident CVD and Mortality
This cohort study assesses whether consuming processed meat, unprocessed red meat, poultry, or fish is associated with incident cardiovascular disease and all-cause mortality among US adults participating in 6 long-term cohort studies.
Toward an integrated classification of neuronal cell types: morphoelectric and transcriptomic characterization of individual GABAergic cortical neurons
Neurons are frequently classified into distinct groups or cell types on the basis of structural, physiological, or genetic attributes. To better constrain the definition of neuronal cell types, we characterized the transcriptomes and intrinsic...
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latest tour de force from the @AllenInstitute now on @biorxivpreprint : integration of morphological, #transciptomic, and electrophysiological information to partition #neuronal cell types
14d
I Performed at the Super Bowl. You Might Have Missed Me.
It was an act of both patriotism and protest. And it brought both joy and frustration.
Ronald Duman, PhD
Dr. Duman received his doctorate degree from the Universityof Texas in Houston and conducted postgraduate work at Yale University beforejoining the faculty there. He has written and/or co-authored over 300 originalpapers, reviews and book chapters,...
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Blessings to Dr. Ronald Duman. He was so kind to me during my graduate training, an excellent mentor that was so down to earth. I'll miss you #RonDuman
15d
Cell stress in cortical organoids impairs molecular subtype specification
Single-cell RNA sequencing clarifies the development and specification of neurons in the human cortex and shows that cell stress impairs this process in cortical organoids.
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I kinda admire Kriegstein and the journals for putting this material out there, that #organoids are not recapitulating ontogeny or anything else, and that improvement is needed
17d
Schizophrenia Is A Disease, Not An Extreme of Normal Variation
Researchers say the current NIMH approach for study of many types of major mental illness is misdirected and must be improved
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Let's not let #Neurodiversity derail all avenues of psychiatry. Some mental states are pathological
17d
Here’s how to make Pandas Iteration 150x Faster
No, it’s not a clickbait.
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Everyone guilty of using .iterrows() raise your hand
Here’s how to make Pandas Iteration 150x Faster by Dario Radečić in @TDataScience
17d
Gunmen, Some In Masks, Swarm KY Capitol For 2nd Amendment Rally
Gun owners from around Kentucky showed up armed at the state’s Capitol building in Frankfort on Friday, rallying for gun...