Snowshoe hares molt from a brown coat to a white coat in winter. In some populations, however, where winter snow is less extensive, hares molt from a brown coat to a brown coat. Jones et al. show that regulation of the pigmentation gene Agouti is...
AbstractSummary. Standardised interfaces for efficiently accessing high-throughput sequencing data are a fundamental requirement for large-scale genomic data s
Thomas Keanehtsget paper is now available. htsget is a secure read/variant streaming standard, intended to standardise access to read/variant data. Read more about it here
Jerome KelleherProud to have played a part in this. A simple, developer-led protocol that helps solve immediate problems. Several client and server implementations, all heavily tested for compatibility. Great leadership from
@ewanbirney and @drtkeane to make it happen.
Multi‐omics studies promise the improved characterization of biological processes across molecular layers. However, methods for the unsupervised integration of the resulting heterogeneous data sets are lacking. We present Multi‐Omics Factor Analysis...
Centromeres and their surrounding pericentric heterochromatic regions remain enigmatic and poorly understood despite critical roles in chromosome segregation 1,2 and disease 3,4. Their repetitive structure, vast size, low recombination rates and...
Grace LeeWhile we know lots about the genetic variation in the euchromatic genome, we know very little about what's going on in the highly repetitive heterochromatin.....until now!!
A big surprise - some of us may have Neanderthal centromeres!!
To define the cell populations in rheumatoid arthritis (RA) driving joint inflammation, we applied single-cell RNA-seq (scRNA-seq), mass cytometry, bulk RNA-seq, and flow cytometry to sorted T cells, B cells, monocytes, and fibroblasts from 51...
Soumya RaychaudhuriOur AMP RA/SLE study describing the single cell populations for rheumatoid arthritis synovial tissue inflammation is out! #rheumatoidarthritis #immunology
This mendelian randomization analysis estimates the magnitude of the change in plasma lipoprotein(a) levels needed to have the same evidence of an association with coronary heart disease risk as a 38.67-mg/dL change in low-density lipoprotein...
Stephen Burgess"Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian randomization analysis" out today at JAMA Cardiology ja.ma/2K52Pf7. Tweetorial follows!
Scientists create pigs that are immune to one of the world's costliest livestock diseases.
The Roslin InstituteRoslin scientist Dr Christine Tait-Burkard told the BBC: "The animals are all pig… with just a tiny section snipped out. The main thing that this edit will do is… benefit animal welfare because the animals will not get a very devastating disease"
Viperin inhibits the replication of various viruses by catalysing the conversion of CTP to ddhCTP, which is a unique nucleotide that functions as replication-chain terminator of RNA-dependent RNA polymerases.
Pancreatic ductal adenocarcinoma in mice induces loss of adipose tissue through altered function of the exocrine pancreas, and supplementing pancreatic enzymes attenuates the wasting of peripheral tissues induced by pancreatic cancer.
ITHACA, NY—According to a study released this week by geneticists at Cornell University, substantial evidence indicates that rich people and poor people—disparate populations long thought to be entirely unrelated—may have once shared a single common...
Genome wide association studies (GWAS) have identified several hundred susceptibility loci for Type 2 Diabetes (T2D). One critical, but unresolved, issue concerns the extent to which the mechanisms through which these diverse signals influencing T2D...