The COVID-19 pandemic has motivated many open and collaborative analytical research projects with real-world impact. However, despite their value, such activities are generally overlooked by traditional academic metrics. Science is ultimately...
Dr Roz EggoAre things that academia values, the most important things in modern science? @AdamJKucharski@sbfnk & I argue probably not.
I hope this can change: many people are doing valuable technical work & they are - & should be able to stay - a part of science.
Edward HillFrom a @PLOSBiology perspective piece by @AdamJKucharski, @sbfnk & @rozeggo:
"By ensuring crucial analytical activities-and the people who do them-are valued in academia, we can enable a more collaborative, impactful and sustainable future for science"
Genetic discordance of the two SARS-CoV-2 specimens was greater than could be accounted
for by short-term in vivo evolution. These findings suggest that the patient was infected
by SARS-CoV-2 on two separate occasions by a genetically distinct...
Dr. Angela RasmussenOkay, new paper out in @TheLancetInfDis.
Yes, this guy was reinfected.
Yes, he got sicker the second time around.
No, it doesn't mean that this is common or that reinfection leads to enhanced disease.
Dr. Angela RasmussenProud to be a signatory of the #JohnSnowMemorandum. This statement, out now in @TheLancet, is the scientific consensus on the COVID-19 pandemic directly refutes the Great Barrington Declaration proposal of "focused protection" as a route to herd immunity.
Marc LipsitchSign the #JohnSnowMemo to support control of COVID-19 rather than uncontrolled "herd" approach
Christophe FraserPleased to sign and support the #JohnSnowMemorandum. Controlling the virus is in our collective power, saving lives and the economy.
Dr. Tom FriedenPlaces hit hardest in Europe in the spring are getting hit hardest now. Maybe percolating infections flaring again, maybe crowded places do worse. But certainly doesn't suggest much of an impact of herd immunity at even moderately high infection rates. bit.ly/2H5sxUEpic.twitter.com/DR3LQ9AG5i
BACKGROUND WHO expert groups recommended mortality trials in hospitalized COVID-19 of four re-purposed antiviral drugs. METHODS Study drugs were Remdesivir, Hydroxychloroquine, Lopinavir (fixed-dose combination with Ritonavir) and Interferon-β1a...
Jeremy FarrarNot the result anyone hoped for. But so important to have robust, definitive data from large randomised trials. Huge credit to everyone involved in @WHO coordinated Solidarity Trial
Adam Kucharski"Remdesivir, Hydroxychloroquine, Lopinavir and Interferon regimens appeared to have little or no effect on hospitalized COVID-19, as indicated by overall mortality, initiation of ventilation and duration of hospital stay."
Wellcome supports science to solve the urgent health challenges facing everyone. We support discovery research, and we’re taking on three worldwide health challenges: mental health, global heating and infectious diseases.
Leila WhitworthThe long awaited new @wellcometrust science strategy is here wellcome.org/strategy
- Focus on 3 programmes: infectious diseases, mental health and global heating (new!)
- Funding more outside the UK
- Restructuring fellowships & stopping salary support for established PIs
Ed Whiting😁to announce our new strategy today- solving the urgent health challenges facing everyone. A few thoughts about what we’re excited about/ how we got here…
A small number of people and events are responsible for most virus transmission – that is why tracing them is so vital, say Kyra Grantz and Justin Lessler of the Johns Hopkins Bloomberg School of Public Health
Bill HanageExcellent article by @khgrantz and @JustinLessler on the importance of the highly clustered nature of transmission for understanding how to handle the pandemic. It’s been said before, but rarely (imo) as clearly or accessibly
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than
35 million people globally, with more than 1 million deaths recorded by WHO as of
Oct 12, 2020. As a second wave of COVID-19 affects Europe, and with winter...
How the world’s greatest public health organization was brought to its knees by a virus, the president and the capitulation of its own leaders, causing damage that could last much longer than the coronavirus.
Dr. Nahid Bhadelia“When the next history of the CDC is written, 2020 will emerge as perhaps the darkest chapter in its 74 years, rivaled only by its involvement in the infamous Tuskegee experiment”
History is being written & it does not look good for this Administration.
Virologic testing for SARS-CoV-2 has been central to the COVID-19 pandemic response, but interpreting changes in incidence and fraction of positive tests towards understanding the epidemic trajectory is confounded by changes in testing practices....
James HayCt values can be used to estimate epidemic dynamics! We show that the distribution of viral loads changes during an epidemic and develop a new method to infer growth rates from cross-sectional virological surveys without using reported case counts.
A proposal to let people with low risk of infection live without constraint could lead to a million or more preventable deaths.
Helen BranswellPursuing a policy of driving to #Covid19 herd immunity would come at a huge costs in terms of lives lost & potentially long-term health consequences for some of the infected, writes John Barry, author of the quintessential history of the 1918 Spanish flu.
Tedros Adhanom Ghebreyesus cites lack of understanding of virus and lasting health effects
Eddie HolmesWHO chief says herd immunity approach to pandemic 'unethical' | World news | The Guardian
Tom InglesbyEncouraging people to get infected in pursuit of herd immunity is unethical and will substantially increase the numbers who die from COVID. @WHO has called it like it is, and US government agencies and scientific academies should be just as clear on it
Bill HanageHe’s right. In the spring it was considered a joke in bad taste. It’s shocking he now has to respond to it as a serious suggestion
In a small study in San Francisco, Abbott’s BinaxNOW identified infectious people nearly as accurately as a P.C.R. test.
Michael MinaNEW! research shows rapid antigen tests can work in a real world setting - with asymptomatic and symptomatic people. The rapid "paper-strip" antigen test called the BinaxNOW detected >90% of people with high viral loads who are likely to be infectious
Isaac BogochExample of how rapid tests are helpful:
People on public transport in San Francisco offered PCR & BinaxNOW rapid #COVID19 test.
PCR detected more positive people, but rapid test was excellent at detecting most people who were capable of transmission.