Our Nature Medicine paper has been published today. Mutations in #SWI/SNF #chromatin remodeling complex sensitize #lungcancer cells to inhibition of #OXPHOS.
Two important papers from researchers on targeting aberrant OXPHOS dependence in cancer - SWI/SNF (Smarca4) mutant #LungCancer And #Glioblastoma & #Leukemia Phase 1 trials ongoing!
Potentially exciting new class of drugs in 2019?
Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer