Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors
Jamanetwork.com 12d 8 tweets
This systematic review and meta-analysis analyzes the incidence of regimen-specific fatal toxic effects associated with the use of immune checkpoint inhibitors for cancer treatment.


H. Jack West, MD 11d ago
From this week's : "Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors". This is largest evaluation of this topic, providing details of how , when, from what regimens, & how often fatalities from immunotherapy occur. Worth knowing.
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Eric Topol 12d ago
We usually only hear and read about the bright side of #cancer immunotherapy. Here's the dark side:
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Andy Biotech 12d ago
Nice review in details incidence and timing of #immunotherapy-related fatalities $BMY $MRK $RHHBY $AZN $PFE
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Toni Choueiri, MD 12d ago
Great work from ⁦⁩ looking ⁦⁩ pharmacovigilance data to study fatal immune-related AEs ⁦⁦⁩, rare but important to be aware.
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Ashish Kamat 12d ago
Fatal toxicity with immune checkpoint inhibitors is not common but does occur; vigilance remains key; most occur in the early period (median 40 days with single agent; 14 days with combination) #bladdercancer #immunotherapy
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Mahmoud Aljurf 4d ago
Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors A Systematic Review and Meta-analysis. A broad range of regimen-specific toxic effects caused fatalities in 0.3% to 1.3% of treated patients. JAMA
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Raul Cordoba, MD, PhD 4d ago
Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors A Systematic Review and Meta-analysis #ImmunoOnc
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Ola Landgren, M.D. 5d ago
Mechanisms of fatal Immune checkpoint inhibitor (ICI) events: large study shows early onset of death with varied causes. Risk varies by therapeutic regimen. Rare events. Important clinical knowledge. #mmsm ⁦⁩ ⁦⁩
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