Genome-wide meta-analysis of depression in 807,553 individuals identifies 102 independent variants with replication in a further 1,507,153 individuals - impressive work from (David Howard) and colleagues... (but... thread 👇)
┳┻| ┻┳| ┳┻| psst!! ┻┳| ┳┻| ┻┳| ┳┻| ┻┳| ┳┻| ┻┳| ┳┻| ┻┳| ┳┻| _ ┻┳| •.•) The preprint of our depression manuscript is ┳┻|⊂ノ is now on bioRxiv: ┻┳| and it's rather exciting ┳┻| ┻┳| ┳┻
Genome-wide meta-analysis of depression in 807,553 individuals identifies 102 independent variants with replication in a further 1,507,153 individuals
Genome-wide meta-analysis of depression in 807,553 individuals identifies 102 independent variants with replication in a further 1,507,153 individuals #bioRxiv
Ditto depression "These findings advance our understanding of the complex genetic architecture of depression and provide several future avenues for understanding aetiology and developing new treatment approaches."
A timely paper for #WorldMentalHealthDay: Genome-wide meta-analysis of #depression identifies 102 independent variants w/ replication in 1.5 million individuals 🆕23andMe collaboration w/ now in :
Well timed 🎉 by presenting 102 variants, 269 genes, and 15 gene sets now associated with depression #WCPG2018 @23andMe
🔘Depression has a heritability of 9% 🔘269 genes for #depression 🔘15 gene-sets #MentalHealthAwarenessWeek
On #WorldMentalHealthDay as I head to #WSPG2018 very excited to see this HUGE advance in #depression #genetics out on BioRxiv.
🔘41 genetic correlations between depression and other traits 🔘2 causal relationships involving depression
I am due to present this research at the World Congress of Psychiatric Genetics (#WCPG2018) this coming Friday (12th October) at 2pm in the Carron room, so if you want to find out more about this research then please do come along.
Genome-wide meta-analysis of depression in 807,553 individuals identifies 102 independent variants with replication in a further 1,507,153 individuals 1.5 million #genetics
And expands on the newest depression meta-analysis (). >100 GWS loci show high enrichment of neuronal (esp. synaptic) roles. Tentatively interesting mendelian randomisation results suggest potential casual relationships #wcpg2018
#GWAS for depression in 800k individuals with a replication in 1.5M individuals. Why are they not combined??? Anyway, nothing much found of interest, PGS validity about r = 0.10 (r^2 = 1%). Pretty meh, so waiting for the next one. #genomics
Clear presentation from of his new massive meta-analytic #GWAS of #depression. Now 102 significant hits, the majority of which were in same direction in 23andMe replication sample. You can see the pre-print here
Genome-wide meta-analysis of depression in 807,553 individuals identifies 102 independent variants with replication in a further 1,507,153 individuals
These findings advance our understanding of the complex genetic architecture of depression & provide several future avenues for understanding aetiology & developing new treatment approaches: Genome-wide meta-analysis of depression in 807,553 individuals.