Ditto depression "These findings advance our understanding of the complex genetic architecture of depression and provide several future avenues for understanding aetiology and developing new treatment approaches."
Genome-wide meta-analysis of depression in 807,553 individuals identifies 102 independent variants with replication in a further 1,507,153 individuals 1.5 million #genetics
┳┻| ┻┳| ┳┻| psst!! ┻┳| ┳┻| ┻┳| ┳┻| ┻┳| ┳┻| ┻┳| ┳┻| ┻┳| ┳┻| _ ┻┳| •.•) The preprint of our depression manuscript is ┳┻|⊂ノ is now on bioRxiv: ┻┳| and it's rather exciting ┳┻| ┻┳| ┳┻
🔘Depression has a heritability of 9% 🔘269 genes for #depression 🔘15 gene-sets #MentalHealthAwarenessWeek
🔘41 genetic correlations between depression and other traits 🔘2 causal relationships involving depression
#GWAS for depression in 800k individuals with a replication in 1.5M individuals. Why are they not combined??? Anyway, nothing much found of interest, PGS validity about r = 0.10 (r^2 = 1%). Pretty meh, so waiting for the next one. #genomics
Genome-wide meta-analysis of depression in 807,553 individuals identifies 102 independent variants with replication in a further 1,507,153 individuals - impressive work from (David Howard) and colleagues... (but... thread 👇)
Genome-wide meta-analysis of depression in 807,553 individuals identifies 102 independent variants with replication in a further 1,507,153 individuals
A timely paper for #WorldMentalHealthDay: Genome-wide meta-analysis of #depression identifies 102 independent variants w/ replication in 1.5 million individuals 🆕23andMe collaboration w/ now in :
Genome-wide meta-analysis of depression in 807,553 individuals identifies 102 independent variants with replication in a further 1,507,153 individuals #bioRxiv
Well timed 🎉 by presenting 102 variants, 269 genes, and 15 gene sets now associated with depression #WCPG2018 @23andMe
On #WorldMentalHealthDay as I head to #WSPG2018 very excited to see this HUGE advance in #depression #genetics out on BioRxiv.
I am due to present this research at the World Congress of Psychiatric Genetics (#WCPG2018) this coming Friday (12th October) at 2pm in the Carron room, so if you want to find out more about this research then please do come along.
Clear presentation from of his new massive meta-analytic #GWAS of #depression. Now 102 significant hits, the majority of which were in same direction in 23andMe replication sample. You can see the pre-print here
Genome-wide meta-analysis of depression in 807,553 individuals identifies 102 independent variants with replication in a further 1,507,153 individuals
And expands on the newest depression meta-analysis (). >100 GWS loci show high enrichment of neuronal (esp. synaptic) roles. Tentatively interesting mendelian randomisation results suggest potential casual relationships #wcpg2018