Our latest work is now out in Science. Possibly the most fascinating dataset that I have had the privilege of working with. By deeply sequencing normal oesophagus we uncovered a hidden world of mutation and selection acting in our tissues as we age. [1/7]
An important #cancer paper on how we've got a big burden of somatic mutations but v small transition -> malignancy et al Well covered by master explainer as the "cancer paradox"
As we go through life, our cells pick up a lot of mutations, but they don't necessarily have the effects we'd expect. Read the research: ($)
Somatic mutant clones colonize the human esophagus with age
As one ages, the normal oesophagus becomes colonised by mutant clones each reaching several mm2 in size, ultimately covering more than 80% of the epithelium. Beautiful work by
check this one out - pretty phenomenal as well! really cool work!
Somatic mutant clones colonize the human esophagus with age
A gorgeous study on mutation with aging, here in the esophagus. Going to take omeprazole now...
"Somatic mutant clones colonize the human esophagus with age"
Somatic mutant clones colonize the human esophagus with age