Harvard University to begin editing sperm with CRISPR, eye towards children with reduced Alzheimer’s risk.
Two parents homozygous for ApoE4 want to do base editing of sperm given AD risk to child. Here is the clinical trial: 1/1/2020: edit sperm, fertilize. 10/1/2020: edited baby born. 1/1/2090: we see if it worked. Not being a luddite, just pragmatic.
The strongest variant for Alzheimer's is also linked to higher IQ (APOE). Selecting against Alzheimer is selecting for IQ. Selection is always multi-dimensional due to ubiquitous genetic correlations, but they mostly benevolent.
Despite CRISPR baby controversy, Harvard University will begin gene-editing sperm - via #digitalhealth
And here I was, thinking that we would maybe be capable to go one entire week without experimenting on genetically modifying humans 😒
"To be clear, there are no embryos involved—no attempt to make a baby. Not yet."
Harvard aims to use CRISPR gene editing to eliminate ApoE4 variant, to reduce Alzheimer's risk. My worry: ApoE4 already spread to 14% of white population, so it can't just be a harmful mutation -- must have had hidden benefits that gene-editing could lose.
Despite CRISPR Baby Controversy, Harvard University Will Begin Gene-Editing Sperm
Despite CRISPR baby controversy, Harvard University will begin gene-editing sperm - via
Despite #CRISPRbabies controversy, Harvard University will begin gene-editing sperm to try and reduce #Alzheimers risk, by via #bioethics #genomics #dementia
Despite CRISPR baby controversy, Harvard University will begin gene-editing sperm - via
Despite CRISPR baby controversy, Harvard University will begin gene-editing sperm: “This is a technology that could save the species, potentially. We as a species need to maintain the flexibility to face future threats, to take control of our heredity.”
Despite CRISPR baby controversy, Harvard University will begin gene-editing sperm