“Nongenetic inheritance could, in fact, be genetic in origin.”
DNA methylation affecting coat color in mice, previously hypothesized to be a result of epigenetic inheritance, turns out to be a result of classic genetic inheritance instead. The methylation of the gene affecting coat color is coded in the genome.
Agouti mice with coat color differences were supposed to be the tip of the iceberg for DNA methylation–based epigenetic inheritance. “This study shows there is no iceberg.”
“I would not … say that epigenetic inheritance is nearly non-existent.”
Classic Mechanism of Epigenetic Inheritance Is Rare, Not the Rule | The Scientist Magazine®