Recovery of trait heritability from whole genome sequence data #biorxiv_genetic
Enjoyed Peter Visschers presentation on the call on recovering the heritability as estimated in twin studies for height and BMI using whole genome sequencing data. Very exciting results. Check out their preprint here:
Recovery of trait heritability from whole genome sequence data
Why are DNA-based heritability estimates lower than those based on twin studies? A big part of it seems to be that the former don't take into account rare variants. Doing so gives estimates very close to twin studies. Adios, missing-heritability problem!?
“Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants”
Recovery of trait heritability from whole genome sequence data
Now this is interesting: Use of WGS and GREML establishes they can discover near full twin heritability. "Recovery of trait heritability from whole genome sequence data"
It took a decade, but "the case of the missing heritability" is solved! Rare variants save the day in this cool whole genome sequencing study of >21,000 people from Peter Visscher & co. Read the here:
This really impressive work by Wainschtein, Visscher, et al, shows that is indeed the case: Recovery of trait heritability from whole genome sequence data
Recovery of trait heritability from whole genome sequence data - really nice papr from and colleagues - rare variants capture "missing heritability"
Recovery of trait heritability from whole genome sequence data #GWAS "Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants.."
Missing heritability explained by rare variants? I hope someone will share a plain language explainer. Is this a fitting exercise or more. Am interested, obviously, in knowing what the value is for polygenic prediction.
Recovery of trait heritability from wgs data: "Here we show that pedigree heritability for height and body mass index (BMI) appears to be fully recovered from whole-genome sequence (WGS) data on 21,620 unrelated individuals of European ancestry"
Why—on average—are children average height of parents? Common genetic variants don't explain enough of it. Brilliant work ; Visscher et al RARE variants picked up on whole genome scan provide that large missing heritability
Now Bogdan Pasaniuc on comparing SNP heritability against heritability: we need to keep in mind the SNPs Loh et al Nat Genet 2015 & others like Wainschetein have recovered heritability #BoG19
“Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants, in particular those in regions of low LD.”
In TOPMed WGS analysis of N~20K, ~50% of height & BMI heritability explained by rare/low-frequency variants (MAF 0.0001-0.1) (covered in )
Missing heritability of complex traits (height .79: BMI .40) accounted for by rare variants in low LD regions!
Accounting for rare genetic variants fully closes the gap between lower GWAT estimates of heritability & higher twin study estimates, at least for height & BMI
New from Visscher: Recovery of trait heritability from whole genome sequence data
Recovery of trait heritability from whole genome sequence data
Mistery solved: Most of the missing heritability for height is recovered from low frequency variants in low LD regions.
Surprise! or should I say "Surprise?"
"variants in the MAF range of 0.0001 to 0.1 explained 0.54 (SE 0.05) and 0.51 (SE 0.11) of heritability for height and BMI, respectively. Our results imply that the still missing heritability of complex traits and disease is accounted for by rare variants"
Recovery of trait heritability from whole genome sequence data #genomics #gwas
> results imply the still missing heritability of complex traits and disease is accounted for by rare variants, in particular those in regions of low LD pretty convincing that negative selection acts on height and BMI (but could also be pop expansion)
Recovery of trait heritability from whole genome sequence data #genetics so those of us at #ASHG18 already knew this result. it's great to start to close the era of the 'heritability-of-the-gaps'
re your 2008 story the missing heritability located
Another preprint argues for a substantial role of RVs for height and BMI
This could be a big step towards solving missing heritability, a major open problem in genetics. Rare SNPs in 40k WGS samples explain 100% of heritability for height, BMI. Genetic risk prediction may soon become much more accurate.