PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
Hyperprogression may occur when PD-1 blockade activates and expands PD-1+ regulatory T cells to overwhelm tumor-reactive PD-1+ effector T cells. #PNAS Possible mechanism for HPD observed by ⁦⁩ and ⁦
Hyper-progression after #IO therapy may occur when PD-1 blockade activates/expands tumor-infiltrating PD-1+ Treg cells to overwhelm tumor-reactive PD-1+ effector T cells ⁦