Remember the CCR5 #CRISPR genome editing that Jiankui He did? Well, it is deleterious, with a >20% increase in all-cause mortality. by Xinzhu Wei and
I feel obligated to have to comment on the many news stories arguing that the “CRISPR babies will likely die young” as an interpretation of our study (). This interpretation is not valid or responsible. 1/4
Paper with advisor Rasmus on the CCR5-delta32 mutation is now online: We find that delta32 homozygous individuals have increased mortality by 21% from age 41 to age 76. This effect on mortality is also independently supported by deviations
The CCR5 gene was the target of the first publicized gene editing experiment in humans, ostensibly to provide resistance to HIV. Now Wei & "estimate a 21% increase in the all-cause mortality" for people with a common 32bp deletion in the gene.
The recklessness of using Cas9 to disrupt CCR5 in the “CRISPR babies” is further highlighted by this new study on the effects of a natural truncation of CCR5. And those babies have a set of mutated CCR5 alleles with uncharacterized properties!
, : CCR5-∆32 is deleterious in the homozygous state in humans
"... 409,693 individuals of British ancestry to investigate fitness effects of the CCR5-∆32 mutation. We estimate a 21% increase in the all-cause mortality rate in individuals who are homozygous for the ∆32 allele. "
What a week for re-analyses and post-publication peer review. This one's a real doozy!
Here's the study showing that HIV-protecting CCR5-delta32 allele is deleterious when homozygous that is discussing #ESEB2019
A cautionary tale: In 2018, the first genetically edited babies, Lulu & Nana were born. #CRISPR was used to induce mutations mimicking the CCR5-∆32 deletion to protect against #HIV. Sadly, homozygotes for the mutation have an increase mortality of 21%.
"Our results show that being homozygous for the ∆32 mutation is associated with reduced life expectancy in a modern cohort, despite the protective effect of the mutation against HIV3."