This is probably the most important data out of #AAIC19 Healthy Lifestyle May Offset Elevated Genetic Risk for #Alzheimer's disease Somewhat comforting esp when we still don't have an effective disease-modifying treatment...
The risk of #Alzheimers in ~200,000 people with polygenic risk score and lifestyle: association of healthy lifestyle w/ favorably modulating risk just presented #AAIC19 and colleagues
A #healthylifestyle was associated with lower risk of #dementia among participants with low or high genetic risk #AAIC19
A retrospective cohort study published in shows that both high polygenic risk and unfavorable lifestyle factors increase the incidence of dementia. The clinical and public health significance need to be further explored.
Ilianna Lourida conducted the first systematic review linking the #Mediterranean #diet to #dementia in 2013: Our newest paper suggests adherence to a healthy #lifestyle is linked to a lower dementia risk, regardless of #genetics:
New research with UK Biobank data has shown that living a healthy lifestyle may help offset a person’s genetic risk of dementia: Read the paper here: #dementia #health #bigdata
If the #Dementia risks associated with #lifestyle and #genetics are independent, then do we need to rethink our intervention strategies? #ExeterDementia
Association of #Lifestyle and #Genetic Risk With Incidence of #Dementia ⁦⁩ #ExeterDementia ⁦⁩ ⁦⁩ ⁦⁩ ⁦⁩ ⁦⁩ ⁦⁩ ⁦
Healthy lifestyle may cut risk of dementia regardless of genes! New paper in looking at ~200K >60 yr-olds over 8 years. #dementia #alzresearch
Important & hopeful study in ⁦⁩ concluding that positive lifestyle behaviors lower #dementia risk, even for those with high genetic risk.
Association of Lifestyle and Genetic Risk With Incidence of #Dementia #SDOH
Kenneth Langa & collaborators examined the association of lifestyle and genetic risk with incidence of #dementia
Latest paper showing no evidence of interaction between lifestyle & common disease genetics. Billed as "can offset high risk genetics with healthy lifestyle" - although here causality of lifestyle factors less certain than similar heart disease study? :-)
So, this recent paper has an altmetric of >1,700... and a 5,300 page supplementary. Kudos if you can guess what it is Warning (massive pdf)
Association of Lifestyle and Genetic Risk With Incidence of Dementia | Dementia and Cognitive Impairment | JAMA | JAMA Network
expert reaction to study looking at lifestyle, genetic risk and dementia | Science Media Centre Association of Lifestyle and Genetic Risk With Incidence of Dementia
Healthy lifestyle choices can override genetic risk for dementia!! “A healthy lifestyle was associated with lower risk of dementia among participants with low or high genetic risk.”
Researchers “found that combining five lifestyle habits...can reduce the risk of Alzheimer’s by 60 percent”... “including eating, exercise, smoking, alcohol consumption, “and their ‘engagement in cognitive stimulation activities.’” - JAMA
Association of Lifestyle and Genetic Risk With Incidence of #Dementia
Association of Lifestyle and Genetic Risk With Incidence of #Dementia