Too much BORIS generates resistance ALK positive neuroblastoma. Topical paper in Nature this week!! 🤦🏼‍♂️
"BORIS is overexpressed in several cancers”. UK friends, this one is for you. (BORIS stands for "brother of the regulator of imprinted sites") BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells
And here was me thinking he was completely useless and incompetant