1/n So excited to share our new paper, "Extreme polygenicity is explained by negative selection" 👇 Thanks to Alkes Price, Armin Schoech, and other co-authors
New today! & colleagues explore the polygenic nature of complex traits
Impressive paper on genomics of common medical conditions: "For most complex traits, the genes & loci with the most critical biological effects often differ from those with the strongest common-variant associations" by & colleagues
Extreme Polygenicity of Complex Traits Is Explained by Negative Selection
Good example of modelling supporting intuition 👉 "Our results suggest that for most complex traits, the genes and loci with the most critical biological effects often differ from those with the strongest common-variant associations."
"for most complex traits, the genes and loci with the most critical biological effects often differ from those with the strongest common-variant associations"