Out now in ! Read the final version of our #collab with Mike Lawrence on more precise #ComputationalModeling of recurrent mutations, revealing the existence of #PassengerHotspots in #cancer.
Getz , Lawrence & co. identify many cancer hotspot mutations as passenger events at inherently mutable genomic sites and develop a model that identifies putative driver hotspots with fewer false-positives than conventional methods.
Passenger Hotspot Mutations in Cancer: Cancer Cell
Passenger Hotspot Mutations in #Cancer. Estimating background mutability on the individual base pair scale. From Lawrence and Getz