Excited to share a paper in our longstanding collaboration with identifying tumorigenic loss of BRD9 in SF3B1-mutant malignancies out today in . Co-led by and Guo-Liang "Chewie" Chew with amazing help from .
Very excited to share our story about how SF3B1 mutations disrupt a SWI/SNF complex to promote #cancer, just out in . Great collaboration with and .
Excited that our paper about SF3B1 mutations in cancer with in is featured in STAT Madness! Please vote for us if you like our paper
CRISPR screen suggests how commonly mutated RNA splicing factor SF3B1 may lead to chromatin remodeling, promote tumorigenesis
Deregulation of Alternative Splicing is a major hallmark of cancer but only few people is working on it. Elucidating biology behind SF3B1 mutation + develpt of spliceosome inh could help the field growing.
The spliceosome is a new frontier in cancer genomics.  This study used a single guide RNA library combined with a CRISPR screen to analyze cancer targets of a mutated gene SF3B1 that influences the splicing of other genes #AML #genomics #spliceosome
A trio of highly instructive papers on disruptive splicing mutations and #cancer importance of non-coding; basis of multiple cancers; mechanism of SF3B1
Three interesting new papers today on how spliceosomal mutations actually drives cancer — and how to correct it U1-snRNA SF3B1 Cool animation from