Human longevity was associated with decreased levels of genes involved in neural overactivity & higher levels of a gene that suppresses neural overexcitation. In animal models, suppression of neural overactivity led to an increased lifespan & vice versa.
News & Views: Signals emanating from the nervous system are potent modulators of longevity. A Nature paper shows that overall neural excitation is also a key determinant of lifespan.
A relationship between the REST #brain gene in humans, decreased neuronal activity, and #longevity (supported by expt'l model) explainer by by Bruce Yankner and colleagues
An unexpected link between the nervous system and #ageing. Research published in suggests that overall neuronal excitation is a major determinant of lifespan, and that it is higher in short-lived individuals and lower in the long-lived. #longevity