Congratulations and team for generating such a great body of work and discovery on EGFR amplification! Advance Online today
Recently published paper being discussed now at #kdm15yr: Histone Lysine Methylation Dynamics Control EGFR DNA Copy Number Amplification ⁦
Study shows that hypoxia and EGF directly promote EGFR amplification; inhibitors of histone lysine methyltransferases or demethylases are able to promote or block extrachromosomal EGFR amplification
Online Today in - Our latest study showing how Histone Lysine Methylation balance regulates DNA amplification of the oncogene - EGFR. 🤓👨🏻‍🔬
This study compounds several ecDNA papers from last week and identifies a potential therapeutic strategy for targeting extrachromosomal EGFR amplification: Histone Lysine Methylation Dynamics Control EGFR DNA Copy Number Amplification. by